What is Tagrisso?
Tagrisso is a treatment for cancer that blocks the spread and growth of cancerous cells within the body. Tagrissois is used to treat non-small-cell lung cancer, which contains an abnormal "EGFR" gene. The doctor will test you to determine if you have this particular gene. Tagrisso can be prescribed when a tumour has advanced to different regions of your body (metastatic) and to prevent lung cancer from recurring following the time your tumour(s) were removed through surgery. Tagrisso may also be prescribed when the cancer of your lungs has spread to different areas of your body and you previously had treatment using an EGFR medication that inhibits tyrosine kinase that didn't work or stopped being effective.
Warnings
Tagrisso could cause lung problems that could cause death. The symptoms may be similar to those of lung cancer. Contact your physician immediately if you notice any recent or deteriorating lung symptoms like breathing difficulties, shortness of breath, coughing, or fever.
Tagrisso could cause heart problems that could cause death. Your physician should examine your heart's health before you begin to take this medication as well as during treatment. Contact your doctor immediately if you experience any of the following signs or symptoms of a heart issue: feeling that your heart is beating or racing, breathing shortness, swelling of your feet and ankles, or feeling faint.
Before taking this medication
It is not recommended to use Tagrisso if you are sensitive to Osimertinib.
To be sure Tagrisso is suitable for you, ask your doctor if you have ever experienced:
- breathing or lung problems;
- An unbalanced electrolyte (such as low or high blood levels of calcium, sodium, and potassium);
- eye issues eye problems
- heart conditions, including long QT syndrome (in the case of you or an immediate family member).
Osimertinib may harm a newborn baby when the father or mother uses this medicine.
- If you're female, you may need the test for pregnancy to make sure that you're not pregnant. Make sure you use birth control while taking this medication for at least six weeks after the last dose.
- If you're male, use birth control when your partner in sex can be pregnant. Use contraceptives for at least four months after the last dose.
- Contact your doctor right away in the event of a pregnancy.
The likelihood of pregnancy is lower if either the father or mother is taking this medication. Both women and men are advised to use birth control to avoid pregnancy because this medication could affect a newborn baby.
Don't breastfeed when you are taking Tagrisso and for at least two weeks following the last dose.
How to take Tagrisso?
Follow the exact dosage as recommended by your physician. Follow the instructions on the prescription label and review all medication guides and instructions on the label.
Tagrisso is usually served daily, whether or not food is included.
To ease swallowing To make swallowing easier, you can put the tablet in the glass along with 2 tablespoons of water. Mix until the tablet is completely dissolving, and then drink it immediately. Add 4–8 ounces of additional water to the glass, stir gently, and drink it right away.
There is a chance that you will require medical tests to determine your heart's health.
Keep Tagrisso at room temperature, far from heat and moisture.
Details on dosage
Usual Adult Dose for Non-Small Cell Lung Cancer:
80 mg taken orally, once a day
The duration of treatment:
Adjuvant setting: Up to 3 years after the disease progresses, toxicity is unacceptable, or for up to 3 years
Lung cancer metastatic: up until it is too late or if there is an unacceptable level of toxicity
Uses:
As adjuvant therapy following removal of tumours for patients with NSCLC (NSCLC) with tumours that have epidermal factor receptor (EGFR) deletions in exon 19 (exon 21 or L858R) variants that are identified using an FDA-approved test
First-line treatment for patients suffering from metastatic NSCLC who have tumours that carry EGFR deletions of exon 19 or L858R exon 21 mutations, according to an FDA-approved test
For the treatment of patients who have cancer that has metastatic EGFR T790M-positive NSCLC, which is detected using an FDA-approved test. The disease has advanced following EGFR tyrosine kinase inhibitor (TKI) therapy.
What happens If I miss a dose?
Do not miss the missed dose, and take your next dose at your regular time. Don't take two doses at the same time.
What happens if I overdose?
Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.
What should be avoided?
Follow the doctor's advice regarding any limitations on foods, drinks, or any activity.
Side effects of Tagrisso
Take immediate medical attention when you notice indications or warnings of an allergy reaction (hives, breathing difficulties, and swelling of your throat or face) or an extreme skin reaction (fever and sore throat, eye burning, irritation, and a red or purple skin eruption with peeling and blisters).
See your doctor right away if you are suffering from:
- Skin spots of redness or purple that don't change colour when you press them and appear bruised or red even over the course of 24 hours (may be visible on your legs, arms, buttocks, or even in your midsection);
- The appearance of rash, redness, or blisters on your palms of your hands or on the soles of your feet;
- New or worsening cough, or trouble breathing
- Heartbeats that are fast or rapid;
- The swelling in your legs and weight gain You may feel exhausted.
- A lightheaded sensation, similar to feeling like you're about to pass out.
- Lower blood-cell counts such as chills, fever, fatigue, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin and feet, cold hands and fingers,
- Eye issues vision problems, watery eyes, increased sensitivities to light, eye redness, or pain.
Your treatment for cancer could be delayed or completely stopped in the event of certain negative side effects.
Common Tagrisso side effects include:
- Low blood cell count;
- Bone pain, muscle joint pain, or bone
- Diarrhoea;
- Tiredness
- Mouth sores, cough;
- Dry skin or rash
- Redness, tenderness, pain, or any other issue on your toenails and fingernails
This is not a comprehensive list of all the side effects. Others could happen. Consult your physician to seek medical advice on the effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.
Interaction with other drugs
Tagrisso could cause a serious heart issue. The risk is greater if you are also taking some other drugs to treat asthma, infections, heart conditions, high blood pressure, mental illness, depression, malaria, cancer, or HIV.
Other medications can interfere with osimertinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Inform your physician about any other medicines you are taking.
