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Belantamab mafodotin

Generic Name: Belantamab mafodotin [bel-AN-ta-mab-MA-foe-DOE-tin].

Brand Name: Blenrep
Dosage Format: Intravenous powder for injection (BLMF 100 mg).
The Class of Drug: Miscellaneous antineoplastics.

What is Belantamab mafodotin?

Belantamab mafodotin is a treatment used to treat the condition of multiple myeloma in adults. Belantamab mafodotin can be prescribed after at least four other treatments have failed to work, failed, or ended their effectiveness. Belantamab mafodotin was approved by the FDA. On a "accelerated" basis, the US Food and Drug Administration (FDA). In clinical trials, some patients responded to the medicine. However, further studies are required.

Belantamab mafodotin can be purchased in a program that is exclusive to It is necessary to be registered in the program and fully understand the potential risks and benefits of this medication. Belantamab and mafodotin could also be used to treat conditions that are not mentioned in this guideline.

Side effects of Belantamab mafodotin

See a doctor immediately. Get medical attention immediately if you notice symptoms that are warning signs of an allergic response, such as difficulty breathing, hives, or swelling of your lips, face, or tongue. A few side effects can be observed when you inject (infusion reactions). Inform your doctor if you feel faint and exhausted, nauseated, lightheaded and itchy, feverish, chilling, short of breath, or if you experience racing heartbeats, breathing problems, or swelling on your face.

Belantamab and mafodotin may cause serious side effects. Contact your physician immediately if you experience:

  • Sudden vision loss.
  • Bleeding, or bruising that is unusually easy, unusual bleeding.
  • Symptoms of bleeding in the brain, such as weakness, dizziness, and confusion, as well as tingling or numbness on one side of your body and a loss of motion on your face.

Contact an eye specialist if you are experiencing any eye issues, eye dryness, changes to your vision, or loss of vision.

The cancer treatment may be delayed or discontinued permanently in the event of certain negative side effects.

Common adverse effects of belantamab and mafodotin could be:

  • Vision change.
  • Eye changes are detected in an eye exam.
  • Infusion reaction.
  • Abnormal lab tests.
  • Fever, tiredness.
  • Nausea.

This is not an exhaustive list of all possible adverse effects.. Other side effects could occur. Consult your physician for advice regarding medical effects. You can report any symptoms to the FDA at 1-800-FDA-1088.


A doctor for eye care will have to inspect your eyes prior to every dose of belantamab mafodotin. Belantamab mafodotin may cause eye issues that could result in blurred vision, a swollen area on the outside of the eye, or even loss of vision.

Before you take this drug

Speak to your doctor if you are ever diagnosed with:

  • Eye problems.
  • Vision issues and vision problems.
  • Issues with bleeding.

You might need to undergo an unfavorable pregnancy test prior to beginning this treatment.

Belantamab mafodotin could cause harm to a baby who is not yet born when either the father or mother is taking this medication.

  • If you're female, do not use mafodotin-belantamab if you're expecting. Utilize the most effective contraception to avoid pregnancy while taking this medication and for a minimum of 4 months following the last dose.
  • If you're male, use effective birth control when your partner can get pregnant. Continue using birth control for a minimum of 6 months after the last dose.
  • Contact your physician immediately. If you become pregnant when both the mother and father are taking belantamab and mafodotin.

This medication can affect fertility (ability to have kids) in both males and females. It is nevertheless important to utilize birth control to stop pregnancy, as belantamab mafodotin may cause harm to a baby who is not born. Don't breastfeed during the course of this medicine or for a minimum of 3 months after the last dose.

How to take belantamab mafodotin?

Belantamab mafodotin injections are delivered as an injection into the vein, generally every three weeks. The healthcare professional will give the injection. Belantamab mafodotin is to be administered slowly, and the infusion could take as long as 30 minutes to finish.

A doctor for eye care will have to check your eyes prior to every dose of this medication. Belantamab mafodotin can cause changes in the cornea's surface and result in vision issues. The more serious side effects could include an ointment on the cornea's surface or loss of vision. Belantamab mafodotin could cause eye problems, but without causing any visual changes initially. Be sure to not skip any eye examinations when using this medication. Follow any directions for applying artificial tears or any lubricating gel to treat dry eyes. Belantamab and mafodotin may also increase the chance of bleeding. You'll need regular blood tests. Your doctor will decide the length of time you will be treated with belantamab and mafodotin.

Details on dosage

Usual Adult Dose for Multiple Myeloma:

2.5 mg/kg (of the body weight) IV for 30 minutes at least once every 3 weeks until progression of disease or unacceptably toxic
Use: To treat adult patients suffering from relapsed or refractory myeloma who have had at least four previous therapies, such as an anti-CD38 monoclonal antibody and a proteasome inhibitor, as well as an immunomodulatory drug.

What happens if I miss a dose?

Consult your physician for the appropriate treatment. If you do not make an appointment to receive the injection of belantamab.

What happens if I overdose?

Since belantamab is administered by a health specialist in a medical setting, it is highly unlikely for an overdose to occur.

What should be avoided?

Wearing contact lenses is not recommended without consulting your physician if you receive belantamab or mafodotin.

Interaction with other drugs

Other drugs can also influence belantamab mafodotin, which includes medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your doctor the medicines you are currently taking and any medications you begin or stop taking.