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Generic name: axicabtagene ciloleucel [AKS-ee-KAB-ta-jeen-SYE-loe-LOO-sel]
The class of drug: miscellaneous antineoplastics

What is Yescarta?

Yescarta is an anti-inflammatory drug that is used to treat large B-cell lymphoma after your initial treatment failed, the cancer recurred within one year of the first treatment, or when at least two treatments have not been effective in reducing the cancer.Yescarta can also be utilised to manage follicular lymphoma in cases where at least two types of treatment have not been effective in reducing the cancer.Large B-cell lymphoma as well as follicular lymphoma are the two main kinds of non-Hodgkin lymphoma.Yescarta is created by removing white blood cells from blood taken from your body via the vein.Yescarta is available in an exclusive program. You have to be enrolled to participate in the programme and be aware of the risks and benefits associated with this medication.


A severe side effect of Yescarta is the cytokine release syndrome, which can cause symptoms like chills, fever, difficulty breathing, nausea, and other symptoms. Your healthcare provider will have medicine readily available to cure this condition when it does occur.Yescarta could also cause nerve issues that could be life-threatening. Contact your doctor or seek medical attention in an emergency in the event that you are experiencing difficulties with your speech, trouble with thinking and memory, confusion, or even a seizure.

Before you take this drug

To ensure that Yescarta is appropriate for you, ask your physician if you've ever experienced:

  • An ongoing or chronic ailment;
  • Memory issues;
  • A seizure;
  • Kidney or liver disease
  • A stroke
  • If you've received an immunisation in the last two weeks,

Women might require pregnancy tests prior to receiving this medicine. You might also have to use birth controls in order to stop pregnancy before and following treatment with Yescarta and chemotherapy.If you are a recipient of YesCarta during pregnancy, the baby's blood could be tested at birth. This will allow you to determine the negative effects that the medicine could have had on the infant.It is not recommended to breastfeed while taking this medication. Consult your doctor regarding the potential dangers.

How to take YesCarta

Yescarta can be purchased only in an approved hospital or clinic and is only available through specially qualified health experts.Yescarta is given after a procedure called leukapheresis (LOO-kuh-fuh-REE-sis).In leukapheresis, some parts of the blood are gathered via a tiny tube (catheter) put in the vein. The catheter is connected to a device that is able to separate the white blood cells in your body from other components of your blood.The cells are then taken to a lab to be processed into Yescarta. Since it takes time to turn the blood cells into axicabtagene-based ciloleucel drugs, you may not receive the medicine the day that your blood cells are taken.

In the 3 to 5 days prior to the time that Yescarta will be administered, you will be treated with chemotherapy to prepare your body for the administration of this drug.Before you are given the medicine, you'll receive other medicines to protect you from serious reactions or side effects.If your body is ready to receive YesCarta, the medical professionals inject the medicine into your vein via an IV.You will be closely monitored for at least 7 days after you have received Yescarta to ensure that you don't suffer from any allergic reactions or other serious adverse consequences.You'll require frequent tests of your blood to make sure this medication hasn't caused adverse side effects.For a minimum of four weeks, you should be near the clinic or hospital where you received the YesCarta. Don't be so far that it takes more than two hours to get from the clinic back.

Details on dosage

Usual Adult Dose for Lymphoma:

2 1 6 chimeric antigen receptor (CAR)-positive active T cells for every kg of body mass by infusion IV; infusion within 30 minutes
Maximum Dose: 2 x 108 CAR-positive viable T cells
Pretreatment: administer an anti-lymphodepleting regimen consisting of cyclophosphamide 500 mg/m2 IV and fludarabine 30 mg/m2 IV on the fifth, fourth, and third days prior to taking this drug in a single dose.Premedication: Inject acetaminophen oral 650 mg along with diphenhydramine 12.5 mg IV or orally for approximately one hour prior to taking this medication.
Do not use prophylactically corticosteroids, as they may affect the action of this medication.
Use: Treatment for large B-cell lymphoma that is resistant to chemoimmunotherapy first-line or occurs within 12 months after first-line chemoimmunotherapy. Treatment of relapsed or resistant large B-cell lymphoma that has been treated with two or more treatments of systemic therapy that includes diffuse B-cell lymphoma (DLBCL) not specified elsewhere, primary mediastinal large B-cell lymphoma (B-cell), high-grade B-cell lymphoma, and DLBCL that result from follicular lymphoma or the relapsed or refractory form of follicular lymphoma (FL) following two or more treatments of systemic therapy

Do I be concerned if I miss a dose?

Contact your physician for advice if you do not complete your chemotherapy treatments or if your doctor tells you to miss the dose of your medication to reduce the risk of side effects from the axicabtagene ciloleucel.

What will happen if I take excessively?

Because this medication is administered by a medical specialist in a medical setting it is highly unlikely for an overdose to occur.

What should be avoided?

This medicine may result in drowsiness, weakness, and confusion, as well as problems in coordination or memory, as well as seizures. Avoid operating machinery or driving for at least eight weeks following the medication you received, Yescarta.Consult your physician before you take a "live" vaccine. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and the nasal flu (influenza) vaccine.Do not give blood, organs, or any other tissues or cells from your personal body.

side effects of Yescarta

Take immediate medical attention If you are experiencing symptoms that indicate an allergy reaction with Yescarta. itching and breathing problems and swelling of your lips, face tongue, throat, or face.A severe side consequence of axicabtagene ciloleucel is known as cytokine-release syndrome (CRS). Contact your healthcare provider immediately in case you are experiencing symptoms of this disorder, such as chills, fever, trouble breathing, anxiety, vomiting that is severe or diarrhoea, irregular or fast heartbeats, feeling lightheaded, or feeling extremely tired or weak. Your healthcare providers will be able to prescribe medication to treat CRS as quickly as it occurs.Also, inform your caregivers or seek medical attention in an emergency If you are experiencing indications of life-threatening nerve issues: problems with speech or thinking, issues with confusion, memory or seizures.

Consult your physician immediately If you suffer from any of the following:

  • Headaches, dizziness;
  • Tremors, anxiety, and sleep problems
  • Strange thoughts or behaviours;
  • Difficulties talking or comprehending the words spoken to you difficulty understanding what is being said to you.
  • Lower blood cell counts (fever, chills, fatigue similar to flu symptoms, mouth sores, skin rashes, easily bruising, unusual bleeding, pale skin on feet and hands, being lightheaded or breathless).

Common Yescarta side effects can be:

  • Nausea, diarrhoea;
  • Low blood cell count;
  • Confusion
  • Fast heartbeats.

This isn't an exhaustive list of possible side effects, and other side effects could occur. Contact your doctor to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Other medications can interfere with axicabtagene and ciloleucel, such as prescription and over-the-counter medications, vitamins, and herbal products.Consult your doctor about current medication and any other medications that you are about to stop or begin using.