The Web Health



Generic name: antihemophilic factor (recombinant) [ant-ee-hee-moe-FIL-ik-FAK-tor]

Brand names: Advate, Adynovate, Afstyla, Eloctate with Fc Fusion Protein, Esperoct,… Show all 14 brands.

Drug class: Miscellaneous coagulation modifiers

What is Recombinate?

The clotting protein recombinant is found in blood. People who have hemophilia A are deficient in clotting factors VIII. This medicine is recombinant and replaces clotting factor VIII.The recombinant recombinant can be used to prevent or treat bleeding in children and adults with hemophilia.Children with hemophilia A and no previous joint damage can benefit from recombinant recombinate.Von Willebrand disease is not treated with recombinant recombinate.Jivi has been approved only for those over the age of 12.Recombinant Recombinate can also be used in other ways not mentioned in the medication guide.

Side effects of Recombinate 

If you experience any of the following symptoms, seek emergency medical attention: itching, swelling, burning, and tingling of the skin; hives; chest pain; tightness; wheezing; difficulty breathing; cold sweat; feeling faint; or pale, cold-colored skin.

The recombinant may have serious side effects. If you experience:

  • Increased bleeding episodes
  • Any bleeding that won't stop
  • Chest pain;
  • Feeling lightheaded, like you might pass out.

Recombination can cause the following side effects:

  • Nose bleeds;
  • Nausea, vomiting, diarrhea;
  • Headache, dizziness;
  • Joint or muscle pain
  • Rash;
  • Flushing (sudden heat, redness, or tingly sensation);
  • Fever, chills;
  • Cough;
  • A weakness
  • Itching, pain, swelling or redness may occur at the injection site.

There may be other side effects. For medical advice on side effects, call your doctor. Report side effects by calling the FDA at 1-800-FDA-1088.

Similar/related drugs

Tranexamic Acid, Desmopressin, DDAVP, Cyklokapron, Roctavian, and Antihemophilic Factor


Follow all instructions on how to store and mix Recombinate. Storage instructions may vary between brands of recombinant recombinate.You may become immune to recombination. This will make it less effective. If this medication seems less effective at controlling bleeding, call your doctor.

Before you take this drug

This medicine should be avoided if your allergic reactions to Recombinate have been severe or if you're allergic to mouse proteins or hamster proteins. If you have an allergy to beef protein, then do not use recombinant.

If you've ever:

  • Heart disease
  • A latex allergy;
  • If you've ever heard that you are an inhibitor of factor viii,

Inform your doctor whether you are breastfeeding or pregnant.

How to take Recombinate?

A blood test will be performed by your doctor to ensure that recombinant recombinate is an appropriate treatment for you if you have a clotting deficiencyFollow all directions and instructions that are included with the medication. Follow the directions on your prescription label.Your doctor will occasionally adjust your dosage. Check the strength of the bottle to make sure that you're using the right potency.An injection of recombinant recombinant into the vein is administered. Your healthcare provider may give you your first dose and teach you to use it properly.You must read all the instructions that are included with your medicine. Before using recombinant recombinate, it must be mixed in a liquid. If you are unsure of how to mix or store your medicine, ask a pharmacist.Wash your hands thoroughly before you prepare and administer your injection.Prepare an injection only when you are ready to administer the drug. If the color of your medicine changes or if it contains particles, do not use it. For new medication, call your pharmacist.

Recombinant Recombinant dosage is based on your weight. Your dose needs may change if you gain or lose weight.Medical tests will be required frequently.You may become immune to recombination. This will make it less effective. If recombinant is less effective at controlling bleeding, call your doctor.Refill your prescription before it runs out. When traveling, make sure to bring enough medication and injectables with you.Keep recombinant Recombinate is unmixed in its original packaging in the refrigerator. Never freeze. Remove the medication from the fridge and allow it to reach room temperature.It is possible to store recombinant recombinate unmixed at room temperature. However, you should not put it in the fridge. Certain brands of medicine may only be kept at room temperature for a specific number of months or up to their expiration date.Follow all storage instructions carefully. Storage instructions may vary between brands.Store away from bright lights. Use before the date of expiration printed on the label.Use the mixture within three hours after mixing it with the diluent. Keep the mixture out of the refrigerator and at room temperature.Every vial or bottle is only for one-time use. After one use, throw it out, even if the medicine is still inside.

Only use a needle or syringe once, and place it in the "sharps container" to prevent punctures. Besure to follow local or state laws on how you should dispose of the container.Keep it out of reach of children and pets.Wear or carry a medical ID to alert others that you suffer from a blood-clotting or bleeding disorder.

What happens if I miss the dose?

Recombinant Recombinate can be used as needed, and you don't need to follow a regular dosing regimen. You may have to take the medication for several consecutive days to stop bleeding. Continue to use the medication as prescribed, and inform your doctor if bleeding persists.Do not wait to take a missed dose. Never take two doses in one go.

What happens if I overdose?

For poison assistance, call 1-800-222-1222 or get immediate medical help.

What should be avoided?

Follow your doctor's instructions if he or she prescribes restrictions for food, drink, and activities.

Interaction with other drug

Other medications, such as prescription drugs, over-the-counter products, herbal products, and vitamins, may also affect Recombinant. Inform your doctor of all the medicines you are currently taking and those that you have started or stopped using.