What is Symproic?
Symproic blocks some of the effects of opioid medications. Sometimes, an opioid is called a drug. Symproic helps reduce constipation that is caused by opioid pain medicines used to treat chronic, severe pain. Naldemedine treats constipation while retaining the pain-relieving properties of the narcotic. Symproic has been shown to be effective for people who have taken opioids (for at least four weeks) in order to treat chronic pain, which is not caused by cancer.
Warnings
Symproic should not be used if your stomach or intestines are blocked. If you experience severe stomach pains that do not subside, stop using Symproic immediately and contact your doctor. (This can cause serious medical issues.)
Tell your doctor about any symptoms you experience, including sweating, feeling cold or hot, tremors, and rapid heartbeats. Other symptoms include a runny, watery nose, a watery eye, vomiting, and diarrhea. Naldemedine can be addictive. This medicine should never be shared with anyone else. MISUSE OF HABIT-FORMING MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH.
Before you take this drug
Symproic should not be used if:
- A blockage of the intestines or stomach
Tell your doctor about any of the following to ensure that Symproic will be safe for you:
- A stomach or intestinal disorder, including Crohn’s disease or diverticulitis;
- A stomach ulcer,
- Liver disease
Your baby may experience opioid withdrawal symptoms if this medication was taken while you are pregnant. Inform your doctor immediately if you are pregnant or planning to become pregnant.
This medication may cause withdrawal symptoms for a nursing infant. Do not breastfeed for 3 days following your last dose of naldemedine. Symproic should not be used by anyone under the age of 18.
Similar/related drugs
Amitiza, Lubiprostone, Movantik, Relistor, Naloxegol, and Methylnaltrexone
How to take Symproic?
Symproic can be taken up to once a day. Please follow all instructions on your prescription label carefully when taking this medication, taking only as directed and not exceeding or prolonging its use beyond what is specified on its label.
This medication may be taken with or without food. If your symptoms don't improve or worsen, call your doctor. Symproic might not be as effective in patients who have taken opioids for less than four weeks. Store the container in its original container, at room temperature, and away from moisture. Stop taking Symproic after you have stopped using opioid pain medication.
Details on dosage
Usual Adult Dose for Constipation—Drug-Induced:
Orally, 0.2 mg once daily
Comment:
If you cease taking opioid painkillers, discontinue therapy immediately.
Use: To treat opioid-induced diarrhea among adults with chronic noncancer pain. This includes patients with chronic pain associated with prior cancer treatment or their treatment but who do not need frequent (e.g., weekly) opioid dosage escalation. Weekly) opioid dosage escalation.
What happens if I miss the dose?
If you are almost due for your next dose, skip the missed one. Never take two doses of the same medicine at once.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
If your doctor prescribes any restrictions regarding food, beverages, or activities, be sure to heed his or her orders.
Side effects of Symproic
If you experience symptoms of an allergic reaction such as hives, difficulty breathing or swelling of lips, face, tongue or throat - call emergency medical assistance immediately!. If you experience any of the following symptoms, tell your doctor: yawning or watery eyes; a runny or stuffy nose; nausea; vomiting; and diarrhea.
If you experience:
- Severe diarrhea;
- Severe stomach pain that won't go away.
Side effects of Symproic include:
- Nausea, vomiting, stomach pain,
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Interaction with other drug
Taken together, certain medications may not always be appropriate. Some drugs may affect the blood levels of drugs that you are taking, increasing side effects or making them less effective.
Other drugs, such as vitamins and herbal products, may interact with naldemedine. Inform your doctor of all medications you are currently taking as well as those you discontinue or begin taking, including any new ones you begin or cease taking.
