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Generic name: ziv-aflibercept [ZIV-a-FLIB-er-sept]
Name of the brand: Zaltrap
Dosage format: intravenous solution (25 mg/ml)
Drug class: VEGF/VEGFR inhibitors

What is Ziv Aflibercept?

Zivziv Aflibercept is utilized as a combination treatment to combat colon cancer that has metastasized to other regions of the organism (metastatic).

Ziv-aflibercept is typically prescribed in conjunction with other medicines that have had no effect or have been discontinued.\Ziv-aflibercept is also employed for other purposes that are not covered in this guideline.

Side effects of Ziv-aflibercept

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as hives, difficulty breathing, or swelling of your lips, face, or tongue,

Ziv-aflibercept may cause bleeding. Call your doctor or seek medical attention in an emergency when you suffer from:

  • Bleeding that is easy to break, bleeding unusually (nose, mouth, vagina, mouth), or any bleeding that does not stop;
  • Indications of bleeding in your body, such as feeling lightheaded, urine that is brown or pink bloody, tarry stools, coughing up blood, or vomit that looks similar to coffee grounds.
  • Indications of bleeding in your brain: sudden loss of strength (especially for one side), serious headaches, and problems with vision or speech.

Ziv-aflibercept can cause serious adverse reactions. Contact your doctor immediately. If you suffer from:

  • Persistent or severe nausea as well as diarrhea;
  • The appearance of ulcers or blisters in your mouth, swollen or red gums, difficulty swallowing
  • Any wound that does not heal;
  • Trouble with concentration, headaches, and thinking problems; loss of vision; seizures;
  • Symptoms of a blood clot: chest pain, abrupt numbness, or weakness;
  • Symptoms of perforation (a tear or hole) in your stomach or in the intestines: signs of perforation; symptoms of perforation (a hole or tear) in your stomach or intestines: persistent stomach pain, changes in your bowel habits;
  • Symptoms of the presence of signs of a fistula (abnormal passageway) in your lower body, such as rectal pain, vaginal discharge that smells foul, and swelling or pain in your stomach. Issues with bowel or urination movements.
  • Dehydration symptoms: feeling extremely thirsty and hot; feeling in a state of not being able to urinate; heavy sweating or dry and hot skin;
  • Symptoms of kidney disease: puffy eyes, swelling of your feet or ankles, weight growth, urine that looks like foam
  • Low white blood cell count—fever, oral sores, and skin sores—painful throat, cough, and breathing problems

Adults who are older may be more likely to suffer from severe diarrhea or become dehydrated.

The cancer treatments could be delayed or discontinued permanently when you experience certain negative side effects.

Common negative side effects of ziv-aflibercept include:

  • Raised blood pressure
  • Low white blood cell count;
  • Nasal bleeding or bleeding;
  • Stomach pain, diarrhea;
  • Oral sores; loss of appetite; losing weight;
  • Fatigue, headaches;
  • Hoarse voice,
  • Abnormal liver or kidney test results.

This is not a comprehensive list of all the side effects. Others could happen. Talk to your doctor for medical advice regarding the effect. It is possible to report any adverse allergic reactions or symptoms to FDA by calling 1-800-FDA-1088.

Similar or related drugs

Keytruda, Avastin, Capecitabine, fluorouracil, Xeloda, and Betaseron


Ziv-aflibercept could cause serious, and sometimes fatal, bleeding. Contact your physician at any time if you experience unusual indications of bleeding, including easy bruising, bloody stool, coughing up blood, feeling lightheaded, or feeling sluggish.

If you are in need of surgery, be sure to inform your surgeon in advance that ziv-aflibercept is the medication you're taking.

Before you take this drug

Speak to your doctor if you have ever suffered from:

  • Bleeding issues;
  • Heart conditions, high blood pressure;
  • Open sores or skin wounds;
  • Procedures as well as dental surgery within the last four weeks.

Ziv-aflibercept could cause harm to an unborn baby. You may need to undergo a pregnancy test before beginning this treatment. Utilize the most effective contraception to avoid pregnancy while taking ziv-aflibercept for at least one month following your last dose. Consult your physician when you fall pregnant.

It is possible for pregnancy to be at lower risk when either the father or mother is taking this medication. Women should continue to use birth control to stop pregnancies because this medication could affect a newborn baby.It is not recommended to breastfeed while you are taking ziv-aflibercept, at least for a month after the dose you last took.

How to take Ziv-aflibercept?

Ziv-aflibercept is administered in the form of an injection into a vein, typically every two weeks. Your healthcare professional will offer the injection.The medicine should be administered slowly, and infusions can last for at least one hour.You'll require frequent medical examinations and blood pressure check-ups.

Ziv-aflibercept could cause problems with wound healing. This can lead to bleeding or an infection. You will need to stop receiving ziv-aflibercept about 4 weeks prior to any procedure or dental work. Avoid taking the medication for a minimum of four weeks after the surgery or until the surgical wound is healed.

Details on dosage

Usual Adult Dose for Colorectal Cancer:

4 mg/kg IV for 1 hour every two weeks. Give this medication prior to any other component that is part of FOLFIRI's regimen on the first day of treatment.
Time of treatment: until the progression of the disease or unacceptable toxic
Use: This drug, in combination with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI), is indicated for patients with metastatic colorectal cancer (mcrc) that is resistant to or has progressed following an oxaliplatin-containing regimen.

What happens if I miss the dose?

Consult your physician for the appropriate treatment. If you do not make an appointment to receive the ziv-aflibercept injection,

What happens if I overdose?

Because ziv-aflibercept is administered by a medical specialist in medical settings, it is highly unlikely for an overdose to be a problem.

Avoid this

Follow the instructions of your physician regarding the food or beverage.

Interaction with other drugs

Other medications can affect ziv-aflibercept, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your doctor about all the medicines you are currently taking as well as any medicines you are about to start or stop taking.