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Name of the generic: lubiprostone [loo-bee-PROS]
The brand name: is Amitiza.
Dosage form: oral capsule (24 mcg; 8 mcg)
Drug class: chloride channel activators

What is Lubiprostone?

Lubiprostone helps treat persistent constipation or constipation due to opioid pain medications.Lubiprostone is also utilised to treat irritable intestinal syndrome in women suffering from constipation as a primary indication.Lubiprostone is also used for reasons not mentioned in this medication guide.

Side effects of Lubiprostone

See a doctor immediately. If you are experiencing symptoms that indicate an allergic reaction, like hives, trouble breathing, and swelling of your lips, face, and tongue,

Lubiprostone may cause serious side effects. Get in touch with your doctor right away in case you suffer from:

  • Persistent or severe vomiting or severe or ongoing nausea;
  • Trouble breathing
  • A feeling of lightheadedness, as if you're about to pass out.

There is a possibility that you'll suffer from lower blood pressure and experience fainting shortly after taking lubiprostone. It's particularly if you've suffered from diarrhea. Stop taking lubiprostone, and contact the doctor in case you are lightheaded after each dose or if you experience extreme diarrhoea.

Common negative side effects of lubiprostone can include:

  • Nausea, stomach pain
  • Diarrhea, gas, bloating,
  • Headache.

It isn't a complete listing of all the side effects. Other side effects could occur. Consult your doctor for medical advice regarding adverse reactions. If you experience any side negative effects to the FDA by calling 1-800-FDA-1088.

Similar or related drugs

Linzess, Amitiza, Trulance, Linclotide, Movantik, Motegrity, and Relistor


Do not take lubiprostone, and consult your physician if you are feeling lightheaded when you take lubiprostone or if you suffer from serious diarrhoea.

Before you take this drug

It is not recommended to use lubiprostone when you are experiencing an obstruction within your digestive tract or if you experience severe diarrhoea.Inform your doctor if you have ever suffered from the liver condition.Inform your doctor if you are nursing or pregnant.If you're nursing, consult your doctor if you observe diarrhoea in your nursing infant.Not authorised to be used by anyone less than 18 years of age.

How to take Lubiprostone?

Follow all instructions on the prescription label and read the medication guide or instructions sheets. Make sure you use the medicine precisely as directed.Include food and drink.Take the capsule in its entirety and don't crush, chew, break, or break it open.You might feel tension in your chest or experience shortness of breath within an hour of taking lubiprostone. The side effect should be gone within 3 hours; however, it could be present again after taking the next dose. Discuss this with your doctor in the event that this reaction gets uncomfortable.Don't take Lubiprostone when you suffer from extreme diarrhoea. Call your doctor to get instructions.Your doctor will examine your health regularly.Place it in a cool, dry place far from light and heat.

Details on dosage

The Usual Adult Dose for Constipation Chronic:

2 times per day
Comments: The efficacy of this medication in the treatment of constipation caused by opioids for patients who are taking diphenylheptane opioids (e.g., methadone) is not confirmed.
Treatment of constipation with chronic idiopathic symptoms and constipation induced by opioids for adults with chronic noncancer pain cancer pain.Normal Adult Dosage for Irritable Bowel Syndrome:8 mg taken orally twice a day
Treatment for constipation caused by irritable bowel syndrome (IBS-C) for women aged 18 years or older

What happens if I miss the dose?

Do not take the medicine for as long as you are able, but do not take any missed doses if it's close to the time of the next dose. Don't have two doses at one time.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow your doctor's advice regarding restrictions on food, drinks, or activities.

Interaction with other drug

Check with your doctor to see if you're taking an opioid pain medication.Other medications may interact with Lubiprostone, which includes medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about any other medicines you take.




Prescription only

Pregnancy & Lactation

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