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Generic name: anti-inhibitor coagulant complex [an-TEE-in-HIB-i-tor-koe-AG-yoo-lant-KOM-plex]
The brand names are: Feiba, Feiba VH Immuno

What is Feiba?

Feiba is a treatment for those who suffer from hemophilia and who have developed antibodies to medications for clotting.

Hemophilia is an inherited blood-clotting disorder that is commonly treated using medications that contain factors for clotting that aid in controlling bleeding. If the body develops antibodies, or "inhibitors," to the clotting factor, the treatment will not be as efficient in stopping bleeding episodes. Feiba can be used to bypass the inhibitors' effects to enhance blood clotting and reduce the chance of bleeding.

Feiba can be used as a treatment or to stop bleeding in patients with hemophilias A or B who are suffering from inhibitors. Feiba can also be utilized to stop bleeding related to surgical procedures in patients with hemophilia, as well as inhibitors. The medicine is not intended to treat bleeding for those who don't have inhibitors.

Feiba is also employed for other purposes that are not covered in this guideline.

Side effects of Feiba

Seek medical attention immediately. If you are experiencing symptoms or warning signs of reactions to an allergen, such as hives, wheezing or breathing difficulties, and swelling of your lips, face, or tongue,

Contact your physician or seek medical assistance in an emergency immediately if you suffer from:

  • Swelling, bruising, or pain around joints;
  • Heart attack symptoms include chest pressure or pain, pain that spreads to your shoulder or jaw, nausea, and sweating.
  • Red blood cells are low (anemia)--pale skin sensation, lightheadedness or breathlessness, and rapid heart rate difficulty concentrating;
  • Indications of signs of stroke—sudden weakening or numbness (especially in one part of your body) or sudden, severe headache or slurred speech issues with balance or vision;
  • Indications for a blood clot inside the lung, such as chest pain, an abrupt cough, wheezing, rapid breathing, and coughing up blood or
  • Symptoms that a blood clot has formed within your leg: swelling, pain, redness, or warmth in both legs.

Common adverse effects of Feiba can be:

  • Anemia;
  • Nausea, vomiting, diarrhea;
  • Bruising;
  • An altered sense of taste or
  • Positive hepatitis B test for antibodies.

This isn't a complete list of all the side effects. Other side effects could be present. Consult your physician to seek medical advice on adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.


Feiba could increase the risk of suffering a stroke or heart attack. Consult your physician or seek medical emergency assistance immediately if you experience sudden weakness or numbness, a headache, or slurred speech. Also, chest pain, difficulty breathing, or a sudden cough accompanied by warmth or swelling within your leg

Before taking this medication

You shouldn't use Feiba if:

  • You've experienced an extreme allergic reaction to Feiba as well as other elements.
  • If you suffer from a blood disease called disseminated intravascular cocoagulation,
  • You have a blood clot that is present in your body.
  • You've recently suffered an attack or stroke.

To be sure Feiba is not harmful to you, consult your physician. If you are suffering from:

  • Coronary arterial disease;
  • A history of a heart attack, stroke, or blood clots;
  • A recent major injury; or
  • A serious infection called sepsis.

It isn't known if this medication could cause harm to a baby who is not yet born. Consult your physician if you are expecting or planning to be pregnant.

It is unclear if the anti-inhibitor complex for coagulation is present in breast milk or whether it can harm nursing babies. Consult your physician if you are nursing babies.

Feiba is derived by removing plasma from humans (parts of blood) that could contain infections and viruses. The plasma donated is examined and treated to decrease the chance of it being contaminated by infectious agents; however, there is still a possibility that it may carry the disease. Discuss with your physician the potential risks and benefits of this drug.

How can I make use of Feiba?

Feiba is administered into a vein via an IV. It is possible to be taught how to administer an IV at home. Don't give yourself this medication if you do not know how to apply the injection properly and get rid of the IV tubing, needles, and other equipment employed.

For treating a bleeding incident, it is typically given every 6–12 hours until the condition improves. In order to prevent bleeding in the normal course, Feiba may be given every two days. Follow the instructions of your doctor for dosing extremely carefully.

If a child is taking this medication, inform your physician if the child's weight has changed or if there are any weight changes. Feiba doses are based upon weight gain in children, and any changes could affect the dosage of your child.

Feiba is a drug in the form of a powder that needs to be mixed with liquid (diluent) prior to use. If you're taking infusions from home, make sure that you know how to blend and keep the medication.

Do not take the medicine if it has changed color or contains particles. Contact your pharmacist to inquire about a new medication.

Utilize the disposable needle and syringe for only one time. Make sure you follow any local or state regulations regarding the disposal of used needles and syringes. Make use of puncture-proof "sharps" disposal containers (ask your pharmacist for one and what to do with them). Keep the container away from animals and children.

Every single-use container (bottle) that contains this medication is only for one use. Toss it away after just one use, regardless of whether there's still a little remaining medicine in it after injecting the dose.

The medicine and diluent should be kept in their original containers and kept at room temperature, free of heat, moisture, and light. Don't allow the medication to become frozen.

After mixing Feiba in the diluting agent, keep it at room temperature and make use of it within 3 hours. Don't refrigerate the mixture.

Wear a medical alert tag or carry an ID card that states that you suffer from hemophilia. Any dentist, doctor, or emergency medical provider who treats you must be aware that you suffer from a blood-clotting or bleeding disorder.

Miss dose:

Contact your doctor for advice. If you have missed a dosage of Feiba,


Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

Avoid this

Follow your doctor's advice regarding any limitations on foods, drinks, or activities.

Interaction with other drugs

Discuss with your physician all the medicines you are currently taking and any new medications you begin or stop taking, particularly:

  • Coagulation factor viia;
  • Aminocaproic acid; or
  • Tranexamic acid.

This list isn't complete. Other drugs that can interfere with the anti-inhibitor complex include prescription and over-the-counter medications, vitamins, and herbal remedies. The interactions of all drugs are mentioned in this medication guide.