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Phenergan (injection)

Generic name: promethazine (injection) [pro-METH-a-zeen]
Name of the brand: Phenergan
Drug classes: antihistamines, phenothiazine antiemetics

What is Promethazine injection?

Promethazine can be used to stop or treat nausea and vomiting triggered by surgery or anesthesia, certain allergic reactions, and pain caused by childbirth or surgery motion sickness, as well as to relax patients prior to surgeries or other medical procedures. Promethazine injections are usually administered when someone is unable to consume the medicine by mouth. Promethazine injections can also be used to treat conditions that are not mentioned in this guide.

Side effects of Promethazine injection

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, like hives, trouble breathing, or swelling of your lips, face, or tongue.

Phenergan may cause serious side effects. Consult your physician immediately if you experience:

  • Discomfort, burning, or skin changes after the injection was administered.
  • Extreme pain, swelling, the sensation of numbness or the sensation of a cold sensation, or discoloration on your toes and fingers;
  • Breathing that is shallow or weak;
  • Hallucinations;
  • Uncontrolled muscle movements in your facial muscles (chewing or smacking your lips, mouth movement, frowning, blinking, or eye movements);
  • Jaundice (yellowing of the eyes or skin);
  • Bleeding or easy bruising (nosebleeds and bleeding gums);
  • A sudden feeling of weakness or discomfort, fever, chills, sore throat or mouth sores, red or swollen gums, difficulty swallowing, or
  • Extreme nervous system reaction: very rigid (rigid) muscles with high fever, sweating, as well as confusion, quick or irregular heartbeats, and tremors as if you're about to faint.

Common adverse effects of Phenergan could include:

  • Drowsiness, dizziness;
  • Your ears are ringing.
  • Double vision;
  • Being anxious;
  • Dry mouth or
  • Tiredness, sleep problems (insomnia)

This isn't an exhaustive list of possible side effects, and others could happen. Contact your doctor for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Similar or related drugs

Prednisone, Trazadone, Hydroxyzine, Ondansetron, Lorazepam, Fluticasone Nasal, and Loratadine


Promethazine shouldn't be given to children younger than two years old. Promethazine could cause serious breathing problems or even death in children who are very young.

Inform your doctor. If you experience any burning, pain, or tenderness around your IV needle during the time promethazine is being injected,

Contact your physician immediately. If you experience symptoms all over your body, including intense pain or burning sensations, swelling, and numbness, You may also experience cold sensations, numbness, extreme skin irritations, or discoloration on your toes or fingers.

Prior to use this drug

You shouldn't take this medication if you are intolerant of promethazine or similar medications like mesoridazine, perphenazine, and prochlorperazine. trifluoperazine, or thioridazine.

Promethazine shouldn't be given to children younger than two years old. Promethazine may cause breathing problems, or even death, for very young children.

Speak to your doctor if you were ever diagnosed with:

  • Asthma, chronic obstructive lung disorder (COPD), sleep apnea, or another breathing disorder;
  • A sulfite allergy;
  • A background of seizures;
  • A weak immune system (bone-marrow depression);
  • Glaucoma;
  • An overly large prostate or issues with urination;
  • Stomach ulcer or obstruction
  • The heart condition (also known as hypertension);
  • Liver disease or
  • If you've ever experienced any serious adverse side effects during the use of promethazine or other phenothiazine,

Consult your physician if you are breastfeeding or pregnant.

How to take Promethazine injection?

Promethazine can be injected deeply into the muscle. The healthcare professional will provide you with the injection. Contact your physician if you are experiencing any pain, burning, or swelling of the needle after promethazine is administered.

Promethazine injections are usually administered for a limited time until it is no longer required or until you are able to take promethazine orally. This medicine may cause unexpected results in certain medical tests. Be sure to inform any doctor treating you that you recently received a promethazine injection.

What happens if I miss a dose?

Since promethazine injections are given by a doctor and administered by a healthcare professional, you are unlikely to not take an injection.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

The symptoms of an overdose can include hyperactive reflexes or a loss of coordination. extreme drowsiness or weakness, weakening eyes, dilation of pupils, shallow or weak breathing, and seizures (convulsions).

What should be avoided?

This medication could impair your ability to think or react. Be aware if you are driving or engaging in activities that require you to remain conscious. Be careful not to get up too quickly from a lying or seated position where you could be dizzy. Make sure to get up slowly and steadily to avoid a fall. Avoid exposure to the sun and tanning beds. Promethazine can cause skin to burn more quickly. Protect yourself with protective clothes and apply sunblock (SPF 30 or greater) in the outdoors.

Interaction with other drugs

Promethazine injections, in conjunction with other medicines that cause you to become drowsy, could cause more of this. Talk to your doctor prior to using opioids, sleeping pills, muscle relaxers, or medication for anxiety and seizures.

Other medications can affect promethazine injection, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your physician about any other medications you take.




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