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Generic name: orlistat OR-li-stat OR-li-stat [OR-li]
The brand names are Alli and Xenical.
The class of drug: peripherally acting anti-obesity agents

What is Xenical?

Xenical blocks some of the fat you consume, stopping it from being absorbed into the body.

Xenical can assist in losing weight or decrease the chance of gaining weight that has been lost. The medication must be taken alongside a low-calorie diet and should only be used by adults.

Xenical is the prescription-strength form of orlistat. It is the Alli version of orlistat and is sold without a prescription.


Do not use Xenical when you are pregnant. It is not recommended to lose weight during pregnancy.

It is not recommended to use this medication if you suffer from digestive issues (problems with the way you absorb food). It is not recommended to use Xenical when you have gallbladder troubles or if you are pregnant. Avoid using alli when you've received an organ transplant, are using cyclosporine, or do not have excess weight.

Xenical is just one part of a comprehensive treatment that also incorporates diet exercises and weight management. A daily dose of fats, proteins, carbohydrates, and fats must be evenly distributed across each of your meals. Make sure you follow your diet, medication, and workout routines carefully.

Do not eat a diet heavy in fat. Foods high in fat when combined with Xenical may increase the chance of having unpleasant effects on the stomach or intestines.

Before you take this drug

It is not recommended to take Xenical. If you have an allergy to orlistat or suffer from malabsorption (an impairment in the ability to take up nutrients and food correctly),

It is also not recommended to use this medicine if you suffer from:

  • Gallbladder disorders gallbladder problems
  • If you are pregnant.

Don't apply if

  • You aren't overweight.
  • You've had an organ transplant
  • You can use cyclosporine to help prevent rejection of organ transplants.

To ensure that Xenical is appropriate for you, ask your doctor if you've previously had:

  • Kidney stones;
  • Gallbladder diseases;
  • Pancreatitis;
  • Underactive thyroid gland;
  • Liver disease;
  • Kidney disease kidney disease
  • An eating disorder (anorexia or bulimia).

Do not take Xenical when you are expecting. Weight loss is not advisable when pregnant, even if you're overweight. Stop taking orlistat and notify your doctor immediately if you find yourself pregnant.

The use of orlistat may affect the body's ability to take in certain nutrients. Vitamins are crucial when you're nursing a baby. Don't use this medicine without consulting a physician's advice if breastfeeding the baby.

Xenical is not a product that is approved for use by anyone less than 12 years of age. Don't offer any of the medications to anyone younger than 18 years of age.

Similar or related drugs

Ozempic, Wegovy, Phentermine, Semaglutide, Saxenda, and Alli

How to take Xenical?

Make sure to use Xenical strictly as per the directions on the label or as directed by your physician. Avoid using in greater quantities, in smaller amounts, or for longer periods than recommended.Do not share this medicine with anyone else, particularly patients with a background of having an eating disorder.Take note of every details about the patient, such as medication guidelines and instructions sheets which you are given. Speak to your doctor or pharmacist for any questions.

Xenical is generally taken three times a day in conjunction with a meal that has fat (no greater than 30 percent of the calories of the meal). It is possible to take the medication at the time of eating or for up to an hour after having eaten.If you don't eat a meal or eat food that does not contain fat, do not take your dosage for that particular meal.The amount of fat in your diet must not exceed 30 percent of the total calories consumed. For instance, if you consume 1200 calories a day, not more than 360 of those calories must be derived from fat.

Look up the label of every food you eat, paying particular attention to the amount in servings for each container. Your nutritionist, doctor, or dietitian can help you create a healthy diet strategy.Xenical is just one part of a comprehensive treatment that includes exercise, diet, and weight management. A daily dose of calories as well as protein and carbohydrates should be evenly distributed over each of your meals. Make sure you follow your diet, medication, and workout routines precisely.

Orlistat can make it difficult for the body to take in certain nutrients, and you might need a vitamin or mineral supplement when taking Xenical. Follow the directions of your doctor regarding the type of supplement you take. Use the supplement before bed or at least 2 hours prior to or after taking orlistat.Place the bottle in a cool, dry place far from heat, moisture, and light. Make sure the bottle is tightly sealed. Discard any remaining Xenical when the expiration date on the label has expired.Make sure you keep track of your medication. Orlistat is a medication that can be misused for weight loss, and you need to be aware of any person who is taking the medication incorrectly and without a prescription.

Details on dosage

Usual Adult Dose for Obesity:

120 mg orally, three times a day, in conjunction with every main meal that contains fat. The dosage is taken at the time of eating or within an hour of finishing the meal.

Usual Pediatric Dose for Obesity:

12-year-olds or older:
120 mg, orally three times a day, in conjunction with each meal that is a source of fat. The dose can be taken at the time of eating or within one hour after eating the food.

What happens if I miss a dose?

You should take the dose you missed as soon as you recall it and not longer than one hour after having eaten. If it's been longer than an hour since the last meal and you missed the dose, just skip it and then take it when you return to your regular time. Do not take additional medication to make up the missing dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

What should be avoided?

Beware of eating foods high in fat, or you may experience negative side effects in your stomach or intestines.If you are also taking cyclosporine, don't take it for 3 hours prior to or within 3 hours after taking Xenical.

If you are also taking the drug levothyroxine (such as Synthroid), be sure not to use it within four hours before or after you have taken Xenical.

Side effects of Xenical

Get immediate medical attention. Get medical attention immediately if you show symptoms of an allergy reaction. Xenical: hives; difficulty breathing; swelling of your lips, tongue, throat, or face

Stop taking Xenical and consult your physician immediately if you suffer from:

  • Severe stomach pain;
  • Intense discomfort in the lower part of your back.
  • The urine is stained with blood or there is difficulty urinate;
  • Kidney issues there is no or little urine output; swelling of your ankles and feet; being tired or sluggish;
  • Liver issues nausea, stomach discomfort, itching, fatigue, and loss of appetite. Black stools, dark urine, and jaundice (yellowing of the eyes or skin).

Common Xenical adverse effects are caused by orlistat's fat-blocking function. These are indications that the medication is functioning well. These effects are typically only temporary, but they may diminish in the course of using Xenical.

  • Stool that is oily or fatty;
  • Oily spotting on your underwear;
  • Oil of brown or orange color in your stool.
  • Gas and oily discharges;
  • Loose stool, a pressing need to use the bathroom, or an inability to manage bowel movements
  • Increase in the amount of stool motions
  • Nausea, stomach pain, and rectal pain.

This isn't a complete list of possible side effects, and other side effects could be present.

Consult your doctor for medical advice about the effect.


If you have any concerns, report the allergic reactions or symptoms to FDA by calling 1-800-FDA-1088.

Interaction with other drugs

Consult a physician or pharmacist to determine whether it is safe to take Xenical when you are using one of these medicines:

  • Amiodarone;
  • Oral diabetes medicine or insulin;
  • Hiv or aids medicines;
  • Seizure medication (especially when your seizures become more severe while you take orlistat);
  • A mineral or vitamin supplement containing beta-carotene or vitamin e as well as
  • Is a blood thinner: warfarin, coumadin, and jantoven.

This list isn't comprehensive. Other medications can interact with orlistat. This includes medications that are prescribed and available over the counter, as well as vitamins and herbal supplements. The interactions of all potential types are not mentioned in this drug guide.




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