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Sudafed PSE

Generic name: Naproxen and pseudoephedrine [na-PROX-en-and-soo-doe-e-FED-rin]
Brand names: Aleve Cold and Sinus, Aleve Sinus and Headache Aleve-D Cold and the Sinus, Aleve-D Sinus and cold, Sudafed Sinus 12 Hour Pressure + Pain Sudafed PSE
Classification of drugs: Upper respiratory combinations

What is Sudafed PSE?

Naproxen is a nonsteroidal anti-inflammatory medication (NSAID). Pseudoephedrine is a decongestant. Sudafed PSE is a combination medicine that is used to treat headaches, sinus congestion, fever, and minor aches and pains brought on by common colds or flu. Sudafed PSE could also be used for other purposes not covered in this medication guide.

Side effects of Sudafed PSE

Seek medical attention immediately. If you notice symptoms of an allergic reaction (hives, breathing difficulties, feeling lightheaded, and swelling in your throat or face) or a severe skin reaction (fever, sore throat, burning eyes, skin irritation, and pink or red skin eruption that causes peeling and blisters), Seek medical attention immediately. If you are experiencing symptoms of stroke or heart attack: chest pain spreading to your shoulder or jaw; sudden weakness or numbness on one side of your body; speech that is slurred; leg swelling; and feeling tired, Sudafed PSE can cause serious adverse effects. Do not use Sudafed PSE immediately and contact your doctor immediately in the event that you experience:

  • Severe dizziness or nervousness; trouble sleeping;
  • Swelling and rapid weight gain
  • Breathlessness;
  • New or worsening stomach pain
  • Symptoms of stomach bleeding, such as bloody or black stools bleeding, coughing up blood, or vomit that resembles coffee grounds.

Common side effects of Sudafed could include:

  • Heartburn, stomach pains, nausea, vomiting;
  • Dizziness;
  • Sleep problems (insomnia); or
  • Feeling anxious or feeling anxious or

This is not an exhaustive list of possible side effects, and others could happen. Contact your doctor for advice on medical adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.

Similar or related drugs

Epinephrine topical, pseudoephedrine, phenylephrine nasal, mometasone nasal, sodium chloride nasal, Afrin, and Excedrin


Naproxen may increase your chance of suffering a fatal heart attack or stroke. Do not take this medicine prior to or after heart bypass surgery (coronary bypass grafts for arteries, also known as CABG). Naproxen can cause intestinal or stomach bleeding, which could be fatal.

Before you take this drug

Naproxen may increase the risk of a fatal stroke or heart attack even when you don't have any risk factors. Don't use Sudafed PSE just before or after heart bypass surgery (coronary bypass grafts, or CABG). Naproxen can also cause bleeding in the stomach or the intestinal tract, which could be fatal. These issues can happen at any time while taking naproxen, particularly for older adults. It is not recommended to take this medicine if you are allergic to pseudoephedrine or naproxen or if you've suffered an asthma attack or a severe allergic reaction following the use of aspirin or an NSAID. Do not take Sudafed PSE if you have taken an MAO inhibitor in the last 14 days. A potentially dangerous drug interaction could occur. MAO inhibitors are isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine, as well as other ones. whether this medicine is suitable for use in the event that you suffer from:

  • Heart disease, high blood pressure, diabetes;
  • A stroke or heart attack;
  • A stomach ulcer or bleeding
  • Asthma
  • A thyroid disorder;
  • Prostate enlargement and urinary issues;
  • Kidney disease, liver failure,
  • If you consume three or more alcoholic drinks in a day.

Do not take Sudafed PSE during pregnancy unless your doctor advises you to. Utilizing an NSAID within the final 20 weeks could cause harm to the baby and cause pregnancy-related complications. Consult your doctor prior to taking this medicine if you are nursing. Not permitted for use by anyone under 12 years of age.

How to take Sudafed PSE?

Use only as directed on the label or as directed by your physician. Make sure you are using the lowest dose that works for treating your condition. Take the tablet in one swallow and don't crush, chew, or break it. Drink this medicine with an entire glass of water. Take it with milk or food if this medicine causes a stomach upset. If you're planning to undergo any kind of surgery, inform the surgeon prior to surgery if you've used this medicine in the last few days. Contact your doctor if you experience a fever that lasts longer than 3 days or if your symptoms don't improve within 7 days of taking the medication. Keep at room temperature, free of heat and moisture.

What happens if I miss the dose?

As cold medicine is taken in the event of need, you might not be following a dose schedule. Don't miss a dose when it's time for the next dose. Don't take two doses at the same time.

What happens if I overdose?

Seek medical attention in an emergency situation or contact the Poison Helpline at 1-800-222-1222.

What should be avoided?

Beware of drinking alcohol. It could increase your risk of bleeding from your stomach. Do not take aspirin unless your doctor has instructed you to. Consult your doctor or pharmacist before taking any different cough or cold medications that have similar ingredients.

What other drugs can have an effect on Sudafed PSE?

Talk to your doctor prior to taking Sudafed PSE if you are taking an antidepressant. Taking certain antidepressants together with an NSAID can cause bleeding or bruises easily.

Ask a pharmacist or doctor before taking Sudafed PSE with any other medicines, particularly

  • A blood thinner (Warfarin, Coumadin, Jantoven);
  • Blood pressure or heart medication, such as diuretics or "water pills";
  • Steroid medicine (such as prednisone).

This list isn't exhaustive. Other drugs can interact with Sudafed PSE, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.