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S-adenosylmethionine (same)

Generic name: S-adenosylmethionine (same) [S– a-DEE-noe-SIL-meth-EYE-oh-neen]
The brand names are: SAM-e, Natrol same.
Dosage form: Oral capsule (200 mg)
The class of drug: Nutraceutical products

What is S-adenosylmethionine (same)?

S-adenosylmethionine (also called same) can be described as a synthetic chemical that is naturally present in the human body.same could be effective in alternative therapies as an aid to treat osteoarthritis.

Same is used in alternative medicine as an efficient treatment for itching, tiredness, and abnormal laboratory tests in those suffering from liver conditions and for improving the symptoms of people suffering from depressive disorders.Other uses that aren't supported by research include treating alcohol-related liver diseases as well as schizophrenia and aging Alzheimer's illness, fibromyalgia, constant back pain, migraine seizures, premenstrual syndrome, and chronic fatigue syndrome.

It isn't certain if same can be effective for treating medical conditions of any kind. The use of this product for medical purposes is not recognized by the FDA. Same shouldn't be used as a substitute for medications recommended by your physician.

Same is typically sold as an herbal supplement. There are no controlled manufacturing guidelines in place for a variety of herbal compounds, and a few supplements sold on the market have been discovered to be infected with harmful metals or substances. Health supplements and herbal remedies should be bought from a reputable source to avoid the possibility of contamination.

SAME is also employed for other purposes that are not covered in this guideline for the product.

Side effects of same

See a doctor immediately. If you notice symptoms or warning signs of allergic reactions such as difficulty breathing, hives, and swelling of your lips, face, and tongue,

Take immediate medical attention. If you experience indications associated with serotonin syndrome, which include hallucinations, agitation, sweating, fever, or shivering, an increase in heart rate, stiffness of muscles, or twitching, You may also suffer from a loss of coordination loss of coordination, nausea, vomiting or diarrhea.

Although not all of the side effects are fully understood, same is thought to be safe for the majority of adults when administered as directed.

Common adverse effects of s-adenosylmethionine could be:

  • Hair color changes
  • Headache, dizziness;
  • Experiencing anxiety or fear;
  • Nausea, loss of appetite nausea and an upset stomach;
  • Dry mouth;
  • Diarrhea, constipation;
  • An increase in sweating increased sweating
  • Sleep problems (insomnia).

It's not a complete list of all possible side effects. Other possible side effects may be observed. Consult your physician for advice regarding medical effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.


It is not recommended to use same if you suffer from bipolar disorder, anxiety disorder, or are taking medication for depression.

Do not take same if you've used an MAO inhibitor within the last 14 days. A risky drug interaction may occur. MAO inhibitors include isocarboxazid linezolid, methylene blue injection rasagiline, phenelzine, and tranylcypromine, among others.

Before you take this drug

You shouldn't make use of SAM if you suffer from bipolar disorder (manic depression), anxiety disorder, or antidepressant drugs.

Don't use same in the event that you've taken an MAO inhibitor within the last 14 days. A potentially hazardous interaction with a medication could happen.MAO inhibitors are isocarboxazid linezolid, methylene blue injection rasagiline, phenelzine, tranylcypromine, and many others.

Inform your physician if you are also taking stimulant medication such as opioids, herbal products, or medications for mental illness, depression, Parkinson's disease, migraine headaches, severe infections, or for the prevention of vomiting and nausea. A reaction to same may cause a serious health condition known as serotonin syndrome.

Consult a pharmacist, doctor, or other healthcare professional about whether it is appropriate for you to take this medication in the event that you suffer from:

  • A planned procedure;
  • Lesch-Nyhan syndrome;
  • Parkinson's disease.

It is unknown if SAM could harm an unborn baby. Do not take this product without medical advice if you're expecting

Same is classified as likely to be unsafe to use when you are nursing the baby. Do not take this product without medical advice if nursing the baby.Don't give a health or herbal supplement to your child without a medical recommendation.

How to take same?

If you are considering using same, consult guidance from your physician. It is also possible to consult someone who is certified in the use of herbal and health supplements.

If you decide to use same, take it as stated on the label or as recommended by your pharmacist, doctor, or other healthcare provider. Don't use more than the amount of same suggested according to the package.

Same should be consumed with a full stomach, at least 30–60 minutes prior to a meal, or two hours following the meal.Consult your doctor if symptoms do not improve or if symptoms become worse.If you are undergoing surgery, then stop taking same at least two weeks in advance.Place it in a cool, dry place far from heat and moisture.

Do I be concerned if I miss a dose?

Do not miss the missed dose, and go for the next scheduled dose.

What will happen if I take excessively?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any food restrictions or beverages.

Interaction with other drugs

Do not use same in the absence of medical consultation if taking any of the following medicines:

  • Dextromethorphan (a cough medicine, such as Robitussin D);
  • Serotonin-related drugs Serotonin-related drugs, for example, antidepressants, stimulants, or medications for migraines;
  • Levodopa;
  • And narcotic medication like meperidine (Demerol), pentazocine, and tramadol (Ultram, Ultracet).

This list isn't comprehensive. Other drugs can interact with same, such as medications that are prescribed and available over the counter, vitamins, and herbal supplements. There are many possible interactions between drugs. Are included here.