The Web Health



Name of the generic: eplerenone [ep-LER-e-none]
Name of the brand: Inspra
Dosage format: oral tablet (25 mg, 50 mg)
Drug classes: aldosterone receptor antagonists, potassium-sparing diuretics

What is Eplerenone?

Eplerenone can be used in order to decrease the chance of dying from cardiac failure following a cardiac attack.Eplerenone can also be employed to treat hypertension.Eplerenone is also employed for other purposes that are not covered in this guideline.

Side effects of Eplerenone

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as symptoms of hives, stomach pain, breathing difficulties, or swelling of your lips, face, or tongue.

Eplerenone could cause serious adverse side effects. Contact your physician immediately in the event that you experience:

  • Feeling lightheaded, as if you're about to pass out.
  • Diarrhea, vomiting;
  • Very little or no urine;
  • Irregular or rapid heartbeats;
  • Trouble breathing
  • Swelling in your lower or upper legs and feet swelling in your lower legs or feet
  • High potassium, nausea, weak sensation, tingling chest discomfort, irregular heartbeats slowing down

Common negative side effects of eplerenone include:

  • High potassium
  • Headache

This isn't a complete list of all the side effects. Other side effects could occur. Contact your physician to seek medical advice on adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Similar/related drugs

amlodipine, lisinopril, metoprolol, losartan, furosemide, carvedilol, and hydrochlorothiazide


You might not be eligible to take eplerenone when you suffer from serious kidney problems, high levels of potassium in your blood, or Type 2 diabetes with higher amounts of albumin (a protein) in your urine.Discuss with your doctor all the medications you are currently taking as well as any new medications you decide to start or stop taking. Numerous drugs interact, and some medications should not be taken together.

Prior to using this drug

It's possible you won't be able to take this medication if you are intolerant of eplerenone or if you suffer from:

  • Hyperkalemia refers to high potassium blood levels;
  • Severe kidney disease severe kidney disease
  • Type 2 diabetes is associated with an increase in albumin (a protein) in your urine.

Certain medications can trigger unwanted or hazardous effects when they are taken together with eplerenone. Your doctor might alter the treatment plan in the event that you use any of the following:

  • Nefazodone;
  • A potassium supplement;
  • An antibiotic—clarithromycin, telithromycin;
  • Antifungal medicine: itraconazole, ketoconazole;
  • Diuretic (or "water pill): amiloride, spironolactone, triamterene,
  • Antiviral medicine used to treat hiv/aids: indinavir (nelfinavir), ritonavir, and saquinavir.

Inform your doctor if you were ever diagnosed with:

  • Kidney disease;
  • Diabetes;
  • Liver disease;
  • High cholesterol or triglycerides;
  • If you are taking other blood pressure or heart medication,

Inform your doctor if you are nursing or pregnant.

It is unclear if it will cause harm to a baby who is not yet born. However, having a high blood pressure during pregnancy can lead to complications such as eclampsia or diabetes (dangerously excessive blood pressure that can cause medical issues for both the baby and the mother). Heart failure may become more severe during pregnancy and could cause complications like premature birth. The advantages of treating heart failure or hypertension could outweigh the risks for the baby.This medication can affect fertileness (the ability to bear children) in males.

How do I take Eplerenone?

Follow the directions on your prescription label, and review all medication guides and instructions sheets. Your doctor may alter the dosage. Make sure you take the medicine exactly as prescribed.Eplerenone can be taken either with or without meals.There are times when you may require blood tests. Also, your blood pressure needs to be monitored regularly.If you have high blood pressure, you should continue using eplerenone even when you feel good. High blood pressure usually has no signs. It is possible that you will need medication for blood pressure throughout your life.Keep it at room temperature, far from heat and moisture.

Info on dosage

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 25 mg, taken orally every day. Titrate to the dose you want within 4 weeks, if tolerated.
Dosage goal: 50 mg once orally every day.
Use: To prolong the life of stable patients suffering from an asymptomatic heart disease with a decreased ejection fraction (40 percent or less) following the onset of myocardial injury.

Usual Adult Dose for Hypertension:

The first dose is 50 mg orally, once a day.
Dosage for maintenance 50 mg taken orally, every day, either once or twice
Maximum dose: 100 mg/day
Full therapeutic effects are evident within four weeks.
Patients who have poor responses to blood pressure after the first dose can be given a dose of 50 mg twice daily.

What happens if I miss the dose?

You should take the medication as quickly as you are able, but do not take your missed dosage if it's close to the time of the next dose. Don't have two doses at one time.

What happens if I miss the dose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

Avoid this

Avoid using salt substitutes or potassium supplements unless your physician has instructed you to.

Interaction with other drug

Inform your doctor about your current medications. A variety of medications can interact with eplerenone, specifically:

  • Lithium;
  • Heart or blood pressure medications - such as amidarone, benazepril, diltiazem, dronedarone, enalapril lidocaine lisinopril olmesartan valsartan verapamil or similar; may help.
  • These are nsaids (nonsteroidal anti-inflammatory drugs): aspirin, ibuprofen (advil, motrin), naproxen (aleve), celecoxib, diclofenac (also known as indomethacin), diclofe, and many more.

This isn't a complete list, and a variety of other medications could influence the effects of eplerenone. This includes prescription and over-the-counter medications, vitamins, and herbal products. There are many possible interactions between drugs included here.



Prescription only

Pregnancy & Lactation

CSA Schedule*
Related Drugs
Related Stories