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Penicillin G-benzathine

Generic Name: Penicillin G-benzathine [PEN-i-SILL-in-G-BEN-za-theen]
Name of the Brand: Bicillin L-A
Dosage Form: (1,200,000 units/2 mL; 2,400,000 units/4 mL; 600,000 units/mL)Intramuscular suspension
Class of Drugs: Natural penicillins

What is Penicillin G-benzathine?

Penicillin G-benzathine can be described as an antibiotic that is used to treat a variety of types of infections caused by bacteria, such as strep or syphilis. Penicillin G is also used to treat the symptoms of rheumatic fever.Penicillin G-benzathine could also be used for other purposes that are not mentioned in this guideline.

Side effects of Penicillin G-benzathine

Seek medical attention immediately when you are experiencing symptoms warning signs of an allergic response (hives, breathing difficulties, or swelling of your throat or face) or an extreme skin reaction (fever, sore throat, burnt eyes, irritation, and an ailment that is purple or red with peeling and blisters).

Certain side effects can occur when the medication is accidentally injected near a vein or nerve. Inform your doctor immediately if you suffer from:

  • Numbness, pain, burning, tingling, or sensations of being chilled;
  • Skin that is pale or mottled blue-coloured, lips or toes;
  • Intense pain, tingling, swelling, or weakness within your lower leg
  • Weakening within your legs or arms weakness in your legs or arms
  • Discoloration, blistering, peeling, or painful skin conditions where the medication was injectable.

Contact your doctor at any time if you suffer from:

  • Extreme stomach pains; diarrhea that is bloody or watery (even if it's several months after the previous dose);
  • An uneasy feeling that can make you feel as if you're going to faint.
  • Slow heart rate low pulse, fainting breath, slow breathing (breathing could cease);
  • Heartbeats that are fluttering or beating within your chest
  • The confusion, agitation, hallucinations (seeing or hearing things that aren't true), and extreme fear
  • A seizure;
  • Pain, swelling, warmth, bleeding, redness, bleeding, or a lump at the site of injection;
  • Bleeding or bruising;
  • Skin that is pale, yellow, or light; dark-coloured urine;
  • Urination issues
  • Indications of recent signs of a new infection—fever, chills, fever or mouth sores, heat or redness on your skin—or symptoms of a new infection include fever, chills, vaginal irritation, and discharge.

Common side effects of penicillin-benzathine include:

  • Nausea, vomiting, diarrhea;
  • Itching, sweating, allergic reaction
  • Flushing (sudden heat, redness, or tingly sensation);
  • Experiencing nervousness, anxiety, fatigue, or weakness;
  • Headache, dizziness, or drowsiness;
  • Muscles, joint discomfort,
  • Bleeding, swelling, pain, or a lump when an injection was administered.

This isn't a complete list of all the side effects. Others could happen. Contact your physician for advice regarding medical adverse effects. You can report symptoms to the FDA at 1-800-FDA-1088.

Similar or related drugs

prednisone, amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, and azithromycin


Speak to your doctor if you have ever experienced any allergic reactions to antibiotics.

Before you take this drug

It is not recommended to treat with penicillin G-benzathine if you have an allergy to penicillin.

Inform your doctor if you were ever diagnosed with:

  • An allergic reaction to an antibiotic called a cephalosporin (Keflex, Omnicef, and many others);
  • Any kind of allergic reaction;
  • Asthma or breathing issues;
  • Heart disease
  • Kidney disease.

See your doctor if you are nursing or expecting.

How to take penicillin G-benzathine?

Penicillin G-benzathine can be injected into muscles.Take note of all the instructions for use. Talk to your pharmacist or doctor if you require assistance.Only inject when you are able to administer it. Inform your pharmacist if you notice that the medication has changed color or contains particles.

Don't reuse needles or syringes. Put them in a puncture-proof "sharps" container and dispose of them in accordance with local or state laws. Make sure they are out of pet's and children's reach.

Use this medicine regularly, even if symptoms get better. Inadequate doses can make your condition immune to the medication. Penicillin G-benzathine is not able to cure a viral disease (the flu or a common cold).

Avoid injecting this medication near or within the vein, artery, or nerve. Dangerous or fatal adverse reactions could happen.There is a chance that you will require tests following treatment to ensure that the infection is completely gone.Keep it in the refrigerator. Do not freeze.

What happens If I miss a dose?

Consult your physician for advice in case you missed a dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line toll-free at 1-800-222-1222.

An overdose may cause a seizure.

What should be avoided?

Do not take anti-diarrhoea medication without consulting your physician. Diarrhea could be a sign of a new infection.

Interaction with other drugs

Discuss with your doctor any other medications you take, particularly:

  • Tetracycline;

This list is not exhaustive. Other medications can affect penicillin and benzathine. It includes over-the-counter and prescription medications, vitamins and herbs. The interactions of all drugs are listed here.