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Azuphen MB

Generic name: hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate [HYE-oh-SYE-a-meen, meth-EN-a-meen, METH-il-een-BLUE, FEEN-il-sa-LIS-il-ate, SOE-dee-um-bye-FOS-fate]
Brand names: Phosphasal, Urelle, Uribel, Urimar-T, Urin D/S,… Show all 15 brands
Antispasmodics for the urinary system

What is Azuphen MB?

Hyoscyamine has many different effects on the body. One of them is relief for muscle spasms.Methenamine and methylene blue are mild antiseptics that fight bacteria found in urine and the bladder.The mild pain-relieving effect of phenyl salicylate can be found in this drug.The sodium biphosphate form is made from phosphorus. This is an important substance in all cells of the body.Azuphen MB, a combination medication, is used to treat bladder inflammation (pain and spasms) that results from urinary infection. Azuphen MB can also be used to reduce bladder discomfort when undergoing a medical procedure.Azuphen MB can be used in other ways not mentioned in the medication guide.

Side effects of Azuphen MB

If you experience any of the following symptoms of an allergy reaction, seek immediate medical attention: difficulty breathing, hives, swelling in your lips, face, throat, or tongue.

The side effects of this medicine can be serious. If you experience:

  • Severe dizziness, blurred vision, and a fast heart rate;
  • Urination that is painful or difficult
  • Shortness of breath

This medication may have more side effects for older adults.Your urine or stool will likely appear green or blue if you use methylene blue. It is not harmful and is a side effect that occurs with the drug.

Azuphen mb side effects may include:

  • Dizziness, drowsiness;
  • Dry mouth
  • Nausea, vomiting.

There may be other side effects. For medical advice on side effects, call your doctor. Report any side effects by calling the FDA's hotline at 1-800-FDA-1088.

Similar/related drugs

Amoxicillin, Doxycycline, Ciprofloxacin, Auxilium, Amoxicillin/clavulanate, and Ceftriaxone


Methylene blue can have interactions with many drugs. Do not change your medication without consulting your doctor.Call your doctor if there are any signs that you may be experiencing a drug interaction. These include memory issues, confusion, loss of coordination (mental or physical), muscle twitching or shaking, sweating, or diarrhea.

Before you take this drug

This medicine should not be used if you have an allergy to methenamine, methylene blue, sodium biphosphate, phenylsalicylate, or hyoscyamine.Do not stop or start taking any medications during your treatment with the medicine unless you are told to by your doctor.

Tell your doctor about any of the following to ensure that this medication is right for you:

  • Heart disease
  • A heart rhythm disorder.
  • Congestive heart failure;
  • Coronary heart disease
  • A heart valve disorder;
  • Glaucoma;
  • An enlarged bladder;
  • Myasthenia gravis;
  • An ulcer or obstruction of the stomach.
  • Belladonna, donnatal, or other belladonna products may cause an allergic reaction.
  • Salicylates can cause an allergic reaction (including aspirin, trisalicylate of choline, and magnesium sulfate).

This medication is known to cause harm to an unborn child. If you plan to get pregnant or are already pregnant, tell your doctor.This medication can be passed into breastmilk and harm nursing babies. You should tell your doctor that you are breastfeeding a child.This medicine should not be given to children without consulting a doctor.

How to take Azuphen MB?

Do not take this medicine in larger or smaller amounts or for longer than recommended on the label. Take this medication only as prescribed. Do not exceed the recommended dosage or take it for longer.Take this medication with plenty of fluids.Hyoscyamine may slow down your digestion and make it harder for you to absorb medicines that you consume orally.Keep the bottle at room temperature, away from heat and moisture. When not in use, keep the bottle closed tightly.

What happens if I miss the dose?

As soon as possible, take the missed dose. If your next dose is approaching, skip the missed dose. You should not take more medicine to compensate for a missed dose.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

Avoid this

Take antacids or anti-diarrhea medicines at least 1 hour prior to or after taking hyoscyamine. Anti-diarrhea medicines or antacids can reduce the absorption of hyoscyamine.Wait at least two hours before taking hyoscyamine (methenamine), methylene blue, sodium biphosphate, or phenylsalicylate if you are also taking ketoconazole.

Interaction with other drug

Methylene blue can cause interactions with many drugs. Inform your doctor of all the medications that you are taking. Some medicines may have to be stopped (in some instances, for as long as 5 weeks) before Azuphen MB is prescribed. Do not discontinue any medications before consulting your doctor.

  • Any type of antidepressant
  • ADHD medication includes stimulants and cold or allergy medications.
  • Narcotic pain medicatio
  • Treatment for Parkinson’s disease, restless legs syndrome,
  • A "triptan". Migraine headache

If you have any of these symptoms, call your doctor immediately. If you experience any of the following symptoms, call your doctor immediately: agitation; hallucinations; fever; fast heartbeats and reflexes.This medicine can interact with many drugs. This list does not include all interactions. Hyoscyamine may also make other medicines you swallow less absorbable. Inform your doctor of all medications you are taking, including any that you stop or start using.

  • A diuretic, or "water pills"
  • Sodium bicarbonate potassium Citrate HTML2: sodium citrate combined with citric or potassium
  • Bladder or urinary medicines—darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin;
  • A sulfa drug.

The list of drugs that can cause Azuphen MB to interact is far from complete. Included are prescription, over-the-counter, vitamin, and herb products. List all of your medications with the healthcare providers who treat you.