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Generic name: OnabotulinumtoxinA (Botox) [ON-a-BOT-ue-LYE-num-TOX-in-A]

Brand names: Botox, Botox Cosmetic
Drug class: Skeletal muscle relaxants

What is OnabotulinumtoxinA (Botox)?

Botox can be used by older adults for the treatment of neck dystonia (an abnormal head position) and neck discomfort. Botox can also be used to treat muscle spasms and stiffness (spasticity) of the hands, arms, and legs and feet in children and adults who are at least two years old. The medicine is not used to treat spasticity that is caused by cerebral spasms. Botox can also be used to treat specific eye muscle problems that are caused by nerve disorders in children and adults who are 12 or older. This can be caused by uncontrolled blinking, tightness of the eyelids, or a condition in which the eyes don't point in the same direction.

Botox can also be used in adult patients to manage bladder overactivity as well as urinary incontinence (urine leakage), which has not been assisted by other medications. Botox is a treatment option to treat urinary incontinence caused by nerve disorders, such as those caused by spinal cord injury or multiple sclerosis. Botox can also be used to treat bladder overactivity due to a neurologic condition (such as a spinal cord injury) in children as young as 5 years old if other treatments aren't effective or haven't worked.

Botox can also be used by adults to treat headaches that are chronic. headaches that last for more than 15 days each month and last for four hours or more. Botox is not recommended to treat commonly occurring strain headaches. Botox can also be used to treat extreme underarm sweating (hyperhidrosis) in adults.

Botox Cosmetic is utilized to temporarily diminish facial wrinkles. wrinkles in the face in adults. Botox is also employed for reasons not covered in this drug guideline.

Related drugs

Botox, Gemtesa, Qulipta, Propranolol, baclofen, topiramate, and oxybutynin

Side effects of OnabotulinumtoxinA (Botox)

Take immediate medical assistance. If you are experiencing symptoms warning signs of a reaction such as itching, hives burning, wheezing and breathing problems, and feeling as if you could faint or pass out; swelling of your lips, face, and throat, The botulinum toxins contained in Botox may spread across the body beyond the injection site. This has led to serious, life-threatening adverse effects for those who receive botulinum toxin injections, even for cosmetic reasons. Contact your doctor immediately. If you experience any of the following side effects (up to a couple of hours or weeks following having an injection):

  • Muscle weakness that is unusual or extremely severe (especially in a body part that was not infused by the drug);
  • Loss of bladder control
  • Hoarse voice, difficulty talking or swallowing problems;
  • Eyes that have drooping or sagging eyebrows;
  • Vision changes and pain extremely dry or irritated eyes (your eyes could have a greater sensitivity to light);
  • Chest pressure or pain radiating into your shoulder or jaw, and irregular heartbeats.
  • Burning or pain after you urinate; difficulty getting your bladder empty;
  • The sore throat, cough, chest tightness, breath shortness, or
  • Eyeslid swelling or crusts, or eyelid drainage, issues in your vision.

Common adverse effects of onabotulinumtoxina could include:

  • Urination that is painful or difficult
  • Headache neck pain neck pain or pain in your arms and legs;
  • Symptoms of the cold like nasal stuffiness, sneezing, sore throat,
  • Difficulty swallowing
  • Fever, chills, body aches, flu symptoms;
  • Excessive sweating in other areas than the arms; or
  • Bleeding and redness or swelling at the site where the injection was made.

This list does not encompass every possible side effect and/or adverse reaction that might arise, therefore if any are experienced you should consult your physician as well as report them immediately at 1-800-FDA-1088 for medical advice and report to FDA as soon as possible.


The botulinum toxin in this medication can expand to other body parts beyond the area where it was injected. This could cause dangerous side effects.Consult your physician immediately in the event of a slurred voice, drooping eyes, issues with vision, severe eye irritation, muscle weakness, a loss in bladder control, or difficulty breathing, speaking, or swallowing.

Before you take this drug

It is not recommended to treat it with Botox. If you have an allergy to botulinum toxin or if you suffer from:

  • An infection in the region where the medicine is to be injected.
  • (for the treatment of incontinence or overactive bladder) in the event of an ongoing urinary tract infection or if you're not able to urinate and are not accustomed to using catheters.

Inform your doctor if you were ever diagnosed with:

  • Other botulinum injections, like Dysport, Xeomin, and Myobloc (especially during the last four months),
  • Amyotrophic lateral degeneration (ALS) (also known as "Lou Gehrig's disease");
  • Myasthenia gravis;
  • Lambert-Eaton syndrome;
  • An adverse reaction following previous use of botulinum;
  • A breathing disorder, such as asthma, as well as an emphysema-related condition;
  • Difficulties swallowing
  • Muscle weakness in the face (droopy eyelids, weakness of the forehead, a weak face, difficulty lifting your eyebrows);
  • An alteration in the regular look of the face.
  • Bleeding issues as well as
  • Operation (especially for the face).

Botox is created from donated human plasma and could contain viruses or any other agents that cause infection. Plasma donated is analyzed and treated to decrease the chance of contamination; however, there is a chance that it could be a carrier of the disease. Talk to your doctor regarding your risk.

How to take OnabotulinumtoxinA (Botox)?

Botox injections are only administered by a certified medical professional, not even if they are employed for cosmetic reasons.The medicine is injected into the muscle by a doctor. Botox injections should be given between 3 and 6 months.Botox injections can be injected into more than one region at a time, depending on the problem being treated. When receiving injections for eye muscle problems You may be required to apply eye drops, ointments, an eye-safe contact lens, or any other device to shield the eye's surface. Follow the instructions of your doctor.

If you're being treated for excessive sweating, trim your armpits for approximately 24 hours prior to your injection. Don't apply antiperspirant or deodorant for a period of 24 hours prior to or after your injection. Avoid exercising and drinking hot food or drinks for 30 minutes prior to the injection. It can take as long as 2 weeks following the injections before neck muscle spasm symptoms start to diminish. It is possible to notice the most significant improvement after six weeks.

It could take just one to three days following the injection before the eye muscle spasm symptoms begin to improve. It is possible to see the most significant improvement between two and six weeks. The effects of a Botox injection are only temporary. The symptoms can return within three months. After repeated injections, it could take less and less time until your symptoms recur, particularly in the event that your body develops an antibody against the botulinum toxin.

Do not get botulinum toxin injections from more than one physician at one time. If you switch providers, inform the new provider of the length of time since the last botulinum injection. The use of this medication for longer than the prescribed amount does not increase its effectiveness and could cause severe adverse reactions.

What happens if I miss the dose?

Botulinum toxin is an effect that is temporary and administered at intervals that are widely spaced, so a missed dose will not cause harm.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.

The signs of an overdose may not show immediately but may be accompanied by muscle weakness, difficulty swallowing, or breath that is shallow or weak.

What should be avoided?

Botox could affect the depth of vision and perception. Avoid driving and other hazardous activities until you understand what the effects of this medication will be on your vision and depth perception.

Be careful not to return to your regular physical routine too soon following an injection.

Interaction with other drug

Discuss with your doctor all other medicines you take, including:

  • A muscle relaxer;
  • The cold, also known as allergic medicine,
  • Sleep medicine;
  • An injectable antibiotic;
  • A blood thinner—warfarin, Coumadin, Jantoven, or
  • Medication used to stop blood clots: altreplase, clopidogrel, dipyridamole, ticlopidine, and many more.

This list is not comprehensive. Other drugs that can interact with Botox include prescription and over-the-counter medicines, vitamins, and herbal products. There are many possible interactions between Botox and other drugs. are included here.





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