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Bunavail

Generic Name: Buprenorphine and naloxone (oral or sublingual) [BUE-pre-NOR-feen-and-nal-OX-one].
Drug Class: Narcotic analgesic combinations.

What is Bunavail?

Bunavail buccal films contain buprenorphine in combination with naloxone. Buprenorphine is an opioid medicine, also known as a drug called a narcotic. Naloxone reduces the impact of opioids, such as pain relief and feelings of happiness that can cause the use of opioids. Bunavail buccal film is used to treat addiction to opioids.Bunavail should not be used as a painkiller.

It is believed that the Bunavail brand name has been removed from the U.S. If there are generic versions of this product that were approved by the FDA, it is possible that there are similar products that are available in generic form.

Warnings

The misuse of opioids can lead to addiction, overdose, or even death. Keep the medication at a distance from where others are unable to access it.The use of Bunavail during pregnancy can result in life-threatening withdrawal symptoms for the baby. Side effects that are fatal can be experienced if you take Bunavail in combination with alcohol or other substances that can cause drowsiness or slow breathing.

Before you taking this drug

It is not recommended to take Bunavail in the event that you are allergic to buprenorphine or Naloxone (Narcan).

To be sure Bunavail is suitable for you, inform your doctor if you have ever experienced:

  • Tooth issues, which may include the possibility of having a history of dental cavities.
  • Breathing issues, sleep apnea.
  • An increased prostate Prostate and urinary issues.
  • Kidney disease or liver failure.
  • Spinal curvature that is abnormal and affects breathing.
  • Problems with your gallbladder, thyroid gland, or adrenal gland.
  • A head injury, brain tumor, or seizures.
  • Addiction or addiction to drugs.

If you are taking Bunavail while pregnant, the baby could become dependent on the drug. This can cause withdrawal symptoms that can be life-threatening for the newborn after it's born. Babies born addicted to opioids may require medical care for several weeks. Consult a physician before taking Bunavail if you are nursing. Tell your doctor if you notice a sudden increase in sleepiness or slow breathing in your nursing baby.

How to take Bunavail?

Utilize Bunavail buccal films as directed by your doctor. Follow the instructions on the label of your prescription and study all the medication guides. Do not take Bunavail in greater quantities or for a longer period than prescribed. Inform your doctor if you have a strong urge to take this medication.

Don't give Bunavail to someone else or anyone who has a history of drug addiction or abuse. The misuse of Bunavail can cause addiction, overdose, or death. Place the medication in a location where other people can't access it. The sale or distribution of Bunavail is a violation of the law.Be sure to read and adhere to any instructions for use that come along with your medication. Consult your physician or pharmacist for clarification if you are unsure of the instructions.Cleanse the mouth with clean water after the Bunavail film has disintegrated. After one hour, wait until the medicine has dissolved to clean your teeth to avoid damage to your gums and teeth. It is recommended to have regular dental exams while taking Bunavail.

If you are switching between drugs that contain buprenorphine, it is possible to not use the exact dose for each. Be sure to follow all instructions carefully.Do not stop taking Bunavail in a hurry; otherwise, you might experience painful withdrawal signs. Discuss with your physician how you can effectively stop using this drug.You'll need frequent blood tests to determine your liver's functioning.All your medical providers must be aware that you're being treated for an addiction to opioids and that you are taking Bunavail. Make sure your family members are aware of how to relay this information in the event that they need to speak on your behalf in an emergency.Do not crush or break the Bunavail pill in order to inhale the powder or mix it with liquid for injection into your vein. This has led to the deaths of many.The Bunavail films should be stored in the pouch in a foil bag kept at room temperature and away from heat and moisture. Empty the pouch into the area that pets and children can't reach. Be sure to keep track of your medication. You must be aware if someone is taking it incorrectly or without a prescription.

Do not store any empty bottles of opioids. A single dose can cause death if someone is using Bunavail unintentionally or improperly. Ask your pharmacist for a recycling program that takes back the waste. If there's no take-back program available, you can remove any film that is not being used from the foil packaging and flush it down the toilet. The foil pack that is empty is in the garbage.

Details on dosage

Usual Adult Dose for Opiate Dependence: Buprenorphine monotherapy is typically utilized to induce Bunavail is a possible option to induce patients who are dependent on heroin or other short-acting opioid products. It is important to note that a Bunavail 4.2 mg/0.7 mg buccal film offers the same buprenorphine dosage as one Suboxone 8 mg/2 mg tablet sublingually.

Dosage of inductions

Day 2: Start dose 2.1 mg/0.3 mg taken buccally with intervals of around 2 hours, with further doses resulting in a total dosage in the range of 4.2 mg/0.7 mg. This dose is to manage acute withdrawal symptoms.
Day 2: One dose of up to 8.4 mg or 1.4 mg orally.

Maintenance Treatment: Doses need to be adjusted to a degree that maintains an individual in treatment and also reduces withdrawal symptoms and signs. Dosages should be adjusted to achieve clinical efficacy as quickly as possible. Slow adjustments could result in a higher rate of withdrawal.
-Progressively adjust in increments or decrements of 2.1 mg or 0.3 mg to a level that holds the patient in treatment and suppresses opioid withdrawal signs and symptoms.
The recommended dose is 8.4 mg/1.4 mg taken buccally every day, with intervals of 2.1 mg/0.3 mg up to 12.6 mg/2.1 mg.
Maximum dosage: 12.6 mg/2.1 mg chewed once daily.

What happens if I miss a dose?

Do not take the medicine for as long as you are able, but avoid any missed doses if it's nearing the time to take the next dose. Don't take two doses at once.

What happens if I overdose?

Get medical attention immediately or contact the poison help line at 1-800-222-1222 for help. An overdose of opioids could cause death, especially for children or anyone else who is taking the medication without a prescription. Overdose symptoms may include severe drowsiness and numbness of the pupils, slow breathing, or even no breathing.

What should be avoided?

Avoid drinking or consuming alcohol. Dangerous side effects or death may occur. Avoid operating machinery or driving until you are aware of the effects of Bunavail on your health. Drowsiness or excessive drowsiness may result in accidents, falls, or even serious injuries.

Adverse effects of Buprenorphine and Naloxone

Get immediate medical attention. If you are experiencing symptoms warning of an allergic reaction with Bunavail, such as hives, difficulty breathing, and swelling of your lips, face, and tongue,

Opioid medicines can cause breathing to slow or cease and even cause death. The person who is caring for you must seek urgent medical care if you suffer from prolonged breathing, pauses in your breathing, blue-colored lips, or if you find it difficult to get up.

Contact your doctor immediately or seek medical attention in an emergency. If you suffer from:

  • Gums.
  • Breathing that is weak or shallow, breathing that stops when you sleep.
  • You feel lightheaded, as if you've passed out.
  • Incoordination, confusion, extreme weakness, confusion.
  • Blurred vision, speech slurred.
  • Liver issues: Stomach discomfort, loss of appetite, dark urine; clay-colored stool; jaundice (yellowing of the eyes or skin).
  • Serotonin levels are high within the body and can cause hallucinations, agitation, fever, sweating, shivering, a high heart rate, muscle stiffness, shaking, loss of coordination, nausea, vomiting, and diarrhea.
  • Low levels of cortisol—nausea, vomiting, loss of appetite, dizziness, or worsening weakness or tiredness.
  • Withdrawal symptoms of opioids Shivering, goosebumps, more sweating sensation of cold or hot, runny nose and eyes that water, diarrhea, muscle pain

Breathing problems that are serious could be more prevalent in older people and those with debilitating conditions or who suffer from the syndrome of wasting and chronic breathing conditions.

Common Bunavail side effects can include:

  • Blurred vision, and feeling drunk. Trouble getting your attention.
  • Withdrawal symptoms.
  • The tongue, and redness or numbness within your mouth.
  • Nausea, vomiting, and constipation.
  • Headache, back pain.
  • Heartbeats that are fast or rapid and sweating more intensely.
  • Sleep problems (insomnia).

This is not an exhaustive list of probable adverse effects; more may occur. Contact your doctor for advice regarding medical effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction with other drugs

There is a possibility of breathing issues or withdrawal symptoms if you take or stop using certain other medications. Inform your doctor if you are also taking medication, such as an antibiotic or antifungal medication. blood pressure or heart medications, seizure medication, or medication to treat HIV as well as Hepatitis C.

Opioid medicine may interact with other drugs, causing serious side effects or even death. Be sure your doctor is aware if you take:

  • Medications for allergies or colds, such as bronchodilators, cold or allergy medicines, asthma or COPD medications, or diuretics ("water pills");
  • Medicines to treat motion sickness and irritable bowel syndrome medications for motion sickness, irritable bowel syndrome, or an overactive bladder;
  • Other opioids, such as opioid pain medicine and prescription medicine for cough,
  • A sedative similar to Valium: diazepam, alprazolam, lorazepam, Xanax, Klonopin, Ativan, and many others;
  • Substances that cause you to feel sleepy or reduce your breathing A sleeping pill, a muscle relaxer, or medicine for treating mental illnesses or mood disorders
  • Medications that alter serotonin concentrations in the body. a stimulant or medication for Parkinson's disease, depression, migraine headaches, severe infections, nausea, and vomiting.

This list isn't complete. Other drugs can interfere with buprenorphine and Naloxone, such as prescription and over-the-counter drugs, vitamins, and herbal remedies.

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