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Botox

Generic Name: OnabotulinumtoxinA [ON-a-BOT-ue-LYE-num-TOX-in-A]
Names of Brands: Botox, Botox Cosmetic
Dosage Form: Injection
Drug Class: Skeletal muscle relaxants

Active Ingredient: OnabotulinumtoxinA

The Inactive ingredients: Human albumin as well as sodium chloride.

What is Botox?

Botox injections are prescription medications that improve the look of wrinkles on the face and treat certain health conditions by relaxing muscles because botox blocks nerve signals sent to muscles. Botox cosmetics as well as Botox injections are FDA-approved medications. Botox Cosmetic helps to reduce wrinkles on the face, and Botox injections are utilized to treat medical conditions such as chronic headaches, bladder problems specific to the individual, excessive sweating, and other medical issues. The distinction between Botox and Botox Cosmetic is that they are different in strength once the vial is made out of a substance and are FDA-approved for different applications. So, they shouldn't ever be utilized in conjunction.

Botox and Botox Cosmetic contain onabotulinumtoxin A, which can be described as one of the botulinum toxicants in the class of medications known as neurotoxins. Other botulinum toxins approved by the FDA are abobotulinumtoxina (Dysport), incobotulinumtoxina (Xeomin), daxibotulinumtoxinA-lanm (Daxxify), prabotulinumtoxina (Jeuveau), and rimabotulinumtoxinb (Myobloc).

What Botox used to treat?

  • Face wrinkles: Botox Cosmetic is employed (FDA-authorized) to smooth wrinkles in the face, focusing on the forehead line that is moderate or severe, Crow's feet lines (wrinkles around the corners of your eyes), and frown lines between eyebrows in adulthood.
  • Chronic migraine: Botox is used to treat chronic migraines in adults who suffer from 15 or more headaches per month, lasting for four hours per day or more. In the case of migraines, botox could be injected into seven distinct regions of the neck and head muscles. Results typically last between 12 and 18 weeks, contingent on the specific patient. Botox is not proven to be safe and effective in the treatment of migraines that are episodic (14 headache days or less each month) within seven placebo-controlled trials.
  • Dystonia in the cervical region: Botox is used in patients aged 16 and over to address cervical dystonia, which is an issue that causes the muscles in your neck to contract in a way that is not normal. The result is that your neck turns, which causes the head to sway towards one side, inward, or in reverse.
  • Muscle stiffness: Botox may also help treat stiffness (spasticity) of the hands, arms, legs, feet, and arms in children and adults who are between 2 and 3 years old. Spasticity refers to an unusual increase in the muscles' tone or stiffness that can lead to issues with speech and movement or cause pain or discomfort.
  • Eye muscle disorders: Botox is used to treat specific eye muscle issues that are caused by nerve disorders in children and adults that are at least 12 years old. This can be caused by uncontrolled blinking and tightness of the eyelids (benign vital blepharospasm) as well as an affliction in which the eyes don't point in the exact direction (strabismus).
  • Bladder problems: Botox is used in the adult population to address bladder overactivity or urine incontinence (urine leakage), which has not been treated with other medications. Botox can be used to treat incontinence caused by nerve disorders such as spinal cord injury or multiple sclerosis. Botox can also be used to treat the neurologic disorder neurogenic detrusor hyperactivity (NDO) in children aged 5 years and over. Botox is used only for bladder issues in patients who have an insufficient response or are unable to tolerate an anticholinergic drug.
  • Extreme sweating: Botox is also used to treat extreme sweating in the underarms (primary hyperhidrosis in the axilla) in adults.

Warnings

You shouldn't use Botox in the event of an infection in the region where the medication is to be injected. Botox should not be used to cure an active bladder or incontinence when you are suffering from a bladder infection or cannot urinate (unless you are regularly using it with a catheter).

The botulinum toxin in Botox may spread to different body parts beyond the area where it was injected. It can lead to adverse effects that could be life-threatening. Contact your doctor immediately. If you are suffering from a slurred voice, drooping eyes, difficulties with vision, extreme eye irritation, muscle weakness, loss of bladder control, or difficulty breathing, speaking, or swallowing,

Before you take this drug

You shouldn't be treated with this drug in the event that you are allergic to botulinum toxin or any other ingredients inside Botox, as well as Botox Cosmetic. Also, if you suffer from:

  • An infection within the area in which the medicine will be infected.
  • Or in cases of incontinence and overactive bladder, if you are suffering from a current incontinence or bladder problem, or if you have difficulty urinating and do not regularly utilize a catheter.

To ensure that this medication is suitable for you, inform your physician if you have any of the following:

  • Botulinum toxin injections of different types like Dysport, Jeuveau, Myobloc, Daxxify, Xeomin (especially within the recent four months).
  • Have amyotrophic lateral degeneration (ALS, also known as Lou Gehrig's disease").
  • Myasthenia gravis.
  • Lambert-Eaton syndrome.
  • May have experienced a side effect in the past due to botulinum toxins;
  • Are suffering from breathing problems, such as an asthmatic condition as well as emphysema.
  • Problems with swallowing.
  • Facial muscle weakness in the facial muscles (droopy eyelids, a weak forehead, difficulty lifting your eyebrows).
  • An alteration in the regular look of the face.
  • Bleeding issues as well as.
  • Surgery, particularly around your facial area.

Botox is a product made of donated human plasma and could contain viruses or different infectious agents. Plasma donated is tested and treated in order to lower the risk of contamination; however, there is an opportunity that it might carry diseases. Consult your physician about potential risks.

It isn't known if this medication will cause harm to a baby who is not yet born. Consult your physician if you are expecting or plan to be pregnant.It might not be safe to breastfeed while taking this medication. inform to your doctor about any possible potential risks.

How to take Botox?

The medicine is injected into the muscles by a medical professional. The frequency at which you receive Botox injections is dependent on the condition that is being addressed. Botox cosmetic injections to provide slight improvement of the facial line ought to be scheduled at least 3 months apart. When treating other conditions, the interval could be extended to twelve weeks between treatments. The effects of a Botox injection last for a short time, and the symptoms could be completely gone within three months. After a few injections, you may need shorter and shorter intervals between injections until your symptoms return, particularly in the event that your body develops an antibody against the botulinum toxin.

Botox injections should be administered only by a certified medical professional. This is essentially true when it's about cosmetics. You shouldn't receive botulinum injections from multiple medical professionals at once. If you decide to change health care providers, it's crucial to inform the new physician how long it's been since your last botulinum injection. Utilizing this medication more frequently than recommended does not increase its effectiveness and could cause severe adverse effects.

Use for cosmetic purposes: Botox Cosmetic starts acting or showing its effects generally within the first one to four days, with its maximum effect being seen within the first one to four weeks. The effects of cosmetics usually last for between three and four months but can vary based on the individual.

Chronic migraine treatment: Injections should be administered to seven specific areas of the neck and head, and the recommended schedule of re-treatment is every 12 weeks.

Eye problems: When you receive injections for eye muscle issues You may have to apply drops for your eyes, ointments, a specially designed contact lens, or any other device that protects the cornea. It is critical to follow your doctor's instructions. In the case of eye muscle spasms, it could take 1 to 3 days following injections before symptoms of spasms begin to decrease. It is possible to notice the most significant improvement after 2–6 weeks.

Excessive sweating: If you are receiving treatment for excessive sweating under your arms, then you must cut your arms off about 24 hours prior to the injection. It is not recommended to apply deodorant or antiperspirant for at least 24 hours prior to or after receiving the injection. Avoid exercising and eating or drinking hot food or drinks within 30 minutes prior to the injection.

Neck spasm in the neck: It may take between 2 and 2 weeks following injections before neck spasm symptoms improve. It is possible to notice the most significant improvement after six months.

Adult bladder problems: Before treatment, your doctor could prescribe antibiotics that you use for 1-3 days prior to your treatment, before the date of treatment, and for a period of 1–3 days following the treatment. For more specific instructions (with photos) on dilution and the results, the best way to apply, and the best place to administer Botox Cosmetic as well as Botox, go through "Dosage and Administration" on the Professional Botox Cosmetic document or the Professional Botox document.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222. Overdose symptoms might not manifest immediately but may include muscle weakness, difficulty swallowing, or breath that is shallow or weak.

What should be avoided?

Botox could affect the depth of vision and perception. Avoid driving or engaging in hazardous activities until you understand what this medicine can do to your vision and depth perception. Be careful not to return to regular routines too quickly following an injection.

Side effects of Botox

Seek medical attention immediately. If you notice symptoms warning of an allergic reaction to Botox: hives and itching, wheezing, difficulties breathing, feeling as if you could be passing out, swelling of your lips, face, and tongue, The botulinum toxins contained in Botox may spread across the body beyond the area where it was injected. This has led to dangerous, life-threatening side effects for certain people who have received botulinum injections, even for cosmetic reasons. Get in touch with your doctor right away in the event that you suffer from any of the following side effects (up to a couple of hours or a few weeks after the injection):

  • Muscle weakness that is unusual or extremely severe (especially in an area of the body that was not infused into the area with medication).
  • Loss of bladder control.
  • Hoarse voice, difficulty talking or swallowing difficulties.
  • Eyes that have drooped or wrinkled.
  • Vision changes vision changes; eye discomfort; severe dry or irritated eyes (your eyes could be sensitive to light).
  • Chest pressure or pain radiating to your shoulder or jaw, and irregular heartbeats.
  • Burning or pain after you urinate; difficulty getting your bladder empty.
  • The sore throat, cough, chest tightness, or breathlessness.
  • Eyelid swelling and crusting, or drainage out of your eyelids, as well as eyelid problems such as blurred vision.

Common Botox adverse effects can include:

  • Uncomfortable or difficult to urinate.
  • Neck pain, headaches, back pain, or pain in your legs or arms.
  • Symptoms of a cold like congestion, sneezing, and sore throats.
  • Trouble swallowing.
  • Chills, fever, body aches, and flu-like symptoms.
  • Excessive sweating in other areas than the armpits.
  • Bleeding, bruising, redness, or swelling in the area where the injection was administered.

This isn't a complete list of all the side effects. Other effects may also be present. Contact your doctor to seek medical advice on adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Inform your doctor about all other medications, particularly:

  • A muscle relaxer.
  • Medicines for allergies or colds.
  • Sleep medicine.
  • An injectable antibiotic.
  • A blood thinner (Warfarin, Coumadin, or Jantoven).
  • Medication used to stop blood clots: alteplase, dipyridamole, clopidogrel, and many more.

This list isn't complete. Other drugs can interact with Botox, such as medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between Botox and other drugs. are included here.

DRUG STATUS

Availability

Prescription only

Pregnancy & Lactation

CSA Schedule*

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