What is Milrinone?
Milrinone, a vasodilator used to treat heart failure that can be life-threatening, is an effective short-term remedy.Milrinone can be used in other ways not mentioned in the medication guide.
Side effects of Milrinone
If you experience any of the following symptoms of an allergy: difficulty breathing, hives, swelling in your lips, face, throat, or tongue.
If you:
- Chest pain;
- A feeling of lightheadedness, as if you could pass out.
- Low potassium level—leg cramps constipation, increased thirst, increased urination or muscle weakness, numbness, tingling or numbness, muscle weakness, or limp feeling.
Milrinone can cause a variety of side effects.
- Headache;
- Chest pain;
There may be other side effects. For medical advice on side effects, call your doctor. Report side effects by calling the FDA at 1-800-FDA-1088.
Warnings
You may not have the opportunity to inform caregivers of your medical conditions in an emergency. Make sure that any doctor who treats you in the future knows about your treatment with milrinone.
Similar/related drugs
lisinopril, metoprolol, furosemide, carvedilol, spironolactone, and warfarin
Before you take this drug
If you have an allergy to milrinone, it is best not to use this medication.
Tell your doctor, if possible, before receiving milrinone if you've ever:
- A heart attack;
- A heart valve disorder;
- Heart rhythm disorders
- Low potassium levels in the blood
Inform your doctor of any pregnancy or nursing. You may not know if you're pregnant or nursing in an emergency. Be sure to tell any doctor who is caring for you or your child that this medication was taken.
How to take Milrinone?
Milrinone infusions are given into veins, typically around the clock for 48 hours. This injection will be given by a healthcare professional. You will have your heart rate and blood pressure constantly checked. Blood tests may be required to check your kidney function, electrolytes, and other factors.
Details on dosage
Adult dose for congestive heart failure:
Loading dose: 50 mcg/kg IV over 10 minutes.
Maintenance Infusion: 0.375–0.75 mcg/kg/min
The usual pediatric dose for congestive heart failure is:
Less than one month
Hemodynamic Support: Full-term neonates. Loading Dose: 50 to 75 mcg/kg intravenously administered over 15 mins, followed by a continuous infusion of 0.5 mcg/kg/min; titrate until effect is achieved; a 0.25 to 0.75 mcg/kg/minute range has been used. In one report, a 50-mcg/kg loading dose was administered IV over 15 minutes, followed by continuous infusions of 0.5 mg/kg/minute every 30 minutes for 10 neonates (aged 3 to 27 days, median: 5 days) who had low cardiac output following cardiac surgery. Results showed that milrinone improved hemodynamic parameters, and it was tolerated well.
In a placebo-controlled, randomized trial, 227 full-term neonates (age range: 2 to 6 years; median: 3 months) were given a loading dose of 75 mg/kg administered IV over 60 min, followed by an infusion rate of 0.75 mg/kg/min for 35 hours. This showed a relative risk of the development of low heart output syndrome of 64 percent compared with placebo. A lower dose of milrinone used in the research did not demonstrate a statistically meaningful relative risk of
One month old and older
Dosage administration over 15 minutes. (50 micrograms/kg IV over 15 minutes.
Maintenance Infusion: 0.25-1mcg/kg/min
What happens if I miss the dose?
You are unlikely to miss any doses of milrinone, as it is administered by healthcare professionals.
What happens if I overdose?
Milrinone will only be administered in medical settings. You'll need to watch closely so that you don't receive too much. If you show overdose symptoms, your caregivers will treat you immediately.
What should be avoided?
If your doctor prescribes any restrictions on foods, drinks, or activities, follow their instructions.
Interaction with other drug
Milrinone can be affected by other drugs, such as vitamins and herbal remedies. Inform your doctor of all the medicines you are taking and those that you stop or start using.
