What is Jevtana?
Jevtana, a cancer medication prescribed by a doctor, interferes with cancer cell growth and spread in the body.
Jevtana and prednisone are used to treat metastatic prostate cancer, which is resistant to medical treatment or surgery that lowers testosterone. Jevtana can be given when prostate cancer has progressed after previous treatment with docetaxel.
Warnings
Jevtana should not be used if you suffer from severe liver disease, a low count of white blood cells, or if there is an allergy to polysorbate 80. Jevtana can affect your immune system. If you're 65 years old or older, you may be more susceptible to infections. This includes serious or deadly infections. If you experience a fever or have any of the following symptoms: muscle pain, coughing, diarrhoea, or pain when urinating, call your doctor.
If you experience symptoms like: fever, cough, body aches, easy bruising or bleeding, burning when you urinate, decreased urination, swelling in your hands or feet, severe stomach pain, constipation, blood in your urine or stool, sudden chest pain, and shortness of breath,
An allergic reaction can occur during an injection. Inform your carers immediately if you experience a rash, skin redness, chest pain, difficulty breathing, or feel as if you are about to pass out.
Before you take this drug
Jevtana should not be used if:
- Severe liver disease
- Low white blood cell count;
- Allergy to polysorbate 80 in any medication
Tell your doctor about any of the following to ensure Jevtana will be safe for you:
- Radiation treatment
- Liver or kidney disease
- Breathing problems
- A severe allergic reaction to any medicine
Cabazitaxel is not recommended for women to use. However, if the father uses this medication, it can cause birth defects.
If your partner can get pregnant, use effective birth control. Continue to use birth control at least three months after the last dose. If you become pregnant during this period, tell your doctor immediately. This medication may interfere with your fertility (your ability to have children). It is still important to use birth control to avoid pregnancy, as cabazitaxel may harm the unborn child.
What is Jevtana?
Jevtana can be infused into a vein. This injection will be given by a healthcare provider. The infusion may take up to an hour. Jevtana can be given every three weeks. Other medications will be prescribed to you in order to avoid certain side effects.
Prednisone is a steroid medication that you will likely be taking by mouth daily throughout your Jevtana therapy. Do not stop taking prednisone before consulting your doctor. You could experience unpleasant side effects from Jevtana. Do not discontinue taking prednisone without first consulting with a healthcare provider.
Jevtana can affect your immune system. If you're 65 or older, you may be more susceptible to infections. These infections can even be fatal. You will need to be examined by your doctor on a regular schedule. If you experience persistent nausea, diarrhoea, or excessive sweating, call your doctor. Jevtana can cause you to become dehydrated, which could lead to an electrolyte imbalance. Nduring your Jevtana treatment, your doctor may advise you to monitor your body temperature at home.
Details on dosage
Adult dose for prostate cancer:
25 mg/m2 IV every 3 weeks
Comments:
Use it in conjunction with prednisone or prednisolone.
The medication regimen should be given at least 30 minutes before each administration.
Antiemetics can be given prophylactically or when needed.
Ensure that you are hydrated throughout the treatment.
Use: In combination with prednisone and prednisolone, for patients with metastatic hormone-refractory prostate cancer who have previously been treated with docetaxel.
What happens if I miss the dose?
If you missed your Jevtana appointment, call your doctor to get instructions.
What happens if you overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
Overdose symptoms can include vomiting, diarrhoea, and fever.
What should I avoid when receiving Jevtana?
If your doctor prescribes any restrictions regarding food, beverage, or activity, follow their instructions.
Jevtana side effects
Jevtana may cause an allergic reaction. If you experience any of the following symptoms of an allergic reaction: hives or skin redness, chest tightness, difficulty breathing, feeling light-headed, swelling of the face, lips, or tongue, or if your throat, face, lips, or tongue swell, seek emergency medical attention.
Jevtana may cause serious or even fatal side effects. Contact your doctor immediately if:
- You may experience numbness or burning in your feet or hands.
- Feeling short of breath, chest discomfort or pain, dry cough, wheezing
- Constipation, persistent diarrhoea or vomiting, stomach pain or tenderness
- Blood in the urine, frequent urination, burning, or pain when you urinate
- Low blood cell counts: fever, chills, and muscle pain; mouth sores or skin sores; easy bruising and bleeding; pale skin. Cold hands and feet.
- Signs of stomach bleeding: bloody or tarry stool, coughing blood, or vomit that looks like coffee grounds
- Signs of a Kidney Problem: little or no urinating, painful, or difficult urine; swelling of your hands and feet; feeling tired or breathless.
If you experience certain side effects, your cancer treatment may be stopped or delayed. Some side effects are more common in older adults.
Jevtana may cause side effects such as:
- Fever and low blood cell count
- Numbness or tingling
- Nausea, vomiting, and stomach pain;
- Constipation, diarrhoea;
- Weakness, fatigue;
- Blood in urine
- Joint pain;
- Shortness of breath, cough
- Changed sense of taste
- Hair loss.
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Interaction with other drug
Sometimes it can be unsafe to combine certain medications. Certain drugs could affect blood levels of other medications you're taking and cause side effects or reduce effectiveness, as well as lessen effectiveness altogether.
Other drugs, such as vitamins and herbal products, may interact with Cabazitaxel. Inform your doctor of all the medicines you are taking and those that you stop or start using.
