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Dapagliflozin and saxagliptin

Generic name: dapagliflozin and saxagliptin [DAP-a-gli-FLOE-zin-and-SAX-a-GLIP-tin]

Brand name: Qtern
Dosage form:Oral tablet (10 mg–5 mg; 5 mg–5 mg)
Drug class:Combinations of anti-diabetic drugs

What is Dapagliflozin and saxagliptin?

Dapagliflozin and saxagliptin are combination medicines used in conjunction with diet and physical activity to improve blood glucose control among adults with type 2 diabetes mellitus. Dapagliflozin (saxagliptin) and dapagliflozin are used to reduce the risk of heart attacks, strokes, or heart failure among adults with type 2 diabetes who also have heart problems. Dapagliflozin or saxagliptin are not used to treat type I diabetes or diabetic ketaacidosis. This medication guide does not list all possible uses of dapagliflozin or saxagliptin.

Side effects of Dapagliflozin and saxagliptin

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives; itching; flaking, peeling, or flaking skin; difficulty swallowing; difficult breathing; swelling in your face, lips, or throat. If any of the symptoms listed above occur, seek medical help immediately.The symptoms can get worse very quickly.

If you experience:

  • You may experience severe pain or persistent joint pain.
  • Serious skin reactions: itching, blisters, breakdown in the outer layer;
  • Ketoacidosis is characterized by nausea and vomiting. Other symptoms include stomach pain, confusion, or unusual drowsiness.
  • Pancreatitis: severe pain spreading from your upper stomach to your back with nausea and vomiting and a rapid heart rate
  • Dehydration symptoms: dizziness, weakness, and feeling like you could pass out
  • Signs of a urinary tract infection include pain or burning while urinating, increased urination, and blood in the urine.

Dapagliflozin has been linked to bladder carcinoma in some people, but the cause is still unknown.

Some of the common side effects associated with dapagliflozin or saxagliptin include:

  • Urination problems
  • An elevated blood cholesterol or triglycerides level.
  • Runny nose and sinus pain

There may be other side effects.Call your doctor if experiencing side effects; alternatively, reach out to the FDA at 1-800-FDA-1088 in order to report them.


If you have severe renal disease or are on dialysis, you should avoid using dapagliflozin. You may feel dizzy or weak (especially if you stand up) after taking dapagliflozin or saxagliptin. If you experience signs of pancreatitis (such as severe abdominal pain that spreads to your back and/or spreads from your upper stomach), stop taking this medication immediately. Dapagliflozin may cause serious infections of the vagina or penis. Seek medical attention immediately if there is any burning, itching, or discharge in your genital area or rectal region, or if the pain, tenderness, or redness increases.

Before you take this drug

If you are:

  • If you are suffering from severe kidney disease and currently on dialysis treatment, or are in dialysis treatment now, here is some important advice:
  • A history of severe skin or allergic reactions to dapagliflozin and saxagliptin

As soon as any of the following occur:

  • Kidney disease
  • Diabetic ketoacidosis;
  • Liver disease
  • Cancer of the bladder
  • Other urination issues or bladder infections
  • Surgery for pancreas problems
  • Gallstones;
  • High triglycerides
  • Alcoholism;
  • If you're on a diet that is low in salt,
  • If you are over 65 years old,

You should follow your doctor's instructions when using it during pregnancy. Do not take this medication during the second and third trimesters of pregnancy. This medicine should not be used while breastfeeding. Dapagliflozin or saxagliptin are not recommended for anyone under the age of 18.

How to take Dapagliflozin and saxagliptin?

You may need to have your kidney function checked both before and after treatment with dapagliflozin or saxagliptin. Carefully read all instructions or guides included with your medication and follow them exactly.Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed. Do not chew or crush the tablet. This medication may be taken either with or without food. If you have diarrhea or vomiting, call your doctor. Also, if the amount of food and fluids you take is less than normal or you're sweating a lot more than usual, you should also contact your physician. You will have to check your blood sugar often and may need to test for ketones in your urine. Dapagliflozin may cause life-threatening ketoacidosis. Contact your doctor even if you have normal blood sugar if a urine sample shows ketones. You might feel irritable, anxious, confused, or dizzy if you have low sugar. If you want to treat hyperglycemia quickly, consume or drink sugary foods or drinks (fruit juices, crackers, or raisins). If your hypoglycemia becomes severe, your physician may recommend prescribing an injectable kit of glucagon.Make sure that your family and friends are familiar with how to administer this injection if you need it in an emergency. Watch for symptoms of hyperglycemia, such as an increase in thirst or urination. Stress, illness, surgery, and alcohol consumption can affect blood sugar levels. Consult your doctor before making any changes to your medication or dose schedule. It can interfere with certain medical tests. Inform any doctor that you see about your dapagliflozin or saxagliptin use.Store products away from heat and moisture at room temperature.

Details on dosage

Adult dosage for diabetes type 2:

Patients who do not take dapagliflozin already:
Initial dose: dapagliflozin/saxagliptin orally, once daily in the morning.
Patients who tolerate dapagliflozin and saxagliptin once daily but need additional glycemic management: dapagliflozin ten mg/saxagliptin five mg orally, once per day in the morning.
Before initiating, the volume depletion must be corrected.
This combination drug is not indicated to treat type I diabetes mellitus or diabetic ketoacidosis.
Use: To improve the glycemic level in adults with type 2 diabetes mellitus.

What happens if I miss the dose?

If you are almost due for your next dose, skip the missed one. Never take two doses of the same medicine at once.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. A toxic overdose can lead to life-threatening hypoglycemia. Severe hypoglycemia can cause extreme weakness, confusion, and tremors. It may also lead to sweating, a rapid heartbeat, difficulty speaking, nausea, vomiting, or rapid breathing.

What should be avoided?

You may get dizzy if you stand up quickly from a seated or lying position.

Interaction with other drug

Dapagliflozin or saxagliptin might not work well if you take other medications at the same time. These include prescription and over-the-counter medicines, vitamins, and herbal products. This list does not include all possible interactions. Inform your doctor of all medications you begin or stop taking.



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