The Web Health



Generic name: Dyphylline and guaifenesin [DYE-fil-een-and-gwye-FEN-e-sin] Brand names: Difil G, Difil-G Forte, Jay-Phyl
Drug class: Combinations of antiasthmatics

In the U.S., the Jay-Phyl trademark has been withdrawn. There may be equivalents if generic versions have been approved and tested by the FDA.

What is Jay-Phyl?

Dyphylline works as a bronchodilator. It improves breathing by relaxing the muscles of the airways. Guaifenesin acts as an expectorant. It loosens congestion in the chest and throat, making it easier for you to cough through your mouth. Jay-Phyl, a combination medication, is used to treat coughing and breathing problems that are caused by conditions like bronchial asthma or chronic bronchitis. This medication does not treat emphysema or bronchitis. Jay-Phyl can be used in other ways not mentioned in this guide.

Side effects of Jay-Phyl

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention: hives, difficulty breathing, swelling of your lips, face, tongue, or throat.

Jay-Phyl can cause serious side effects. If you experience:

  • If you feel your heart pounding or your chest fluttering, then this is a sign that it's time to seek medical attention.
  • Rapid breathing; feeling out of breath.
  • Seizure (convulsions); or
  • Vomit or blood that looks like coffee grounds

Jay-Phyl side effects may include:

  • Nausea, vomiting, stomach pain, diarrhea;
  • Headache;
  • Feeling restless or irritabl
  • Sleep problems (insomnia); or
  • Flushing (warmth, redness, or tingly sensation)

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.

Similar/related drugs

Nucala, Prednisone, Amoxicillin, Doxycycline, Ciprofloxacin, Azthromycin, and Augmentin


Jay-Phyl is not recommended for children younger than six years of age.

Before you take this drug

If you have an allergy to dyphylline or guaifenesin, then Jay-Phyl is not for you. This medicine will not treat asthma attacks.

Tell your doctor if:

  • Heart disease, or a history of heart attacks.
  • High blood pressure
  • Liver or kidney disease
  • Overactive thyroid
  • A stomach ulcer,
  • If you are taking a beta blocker (atenolol or other beta-blockers such as bisoprolol and carvedilol), then this is a warning.

FDA pregnancy class C There is no information on whether Jay-Phyl can harm an unborn child. If you plan to get pregnant or are already pregnant, tell your doctor. Dyphylline, guaifenesin, and other drugs can be passed into breast milk. This may cause harm to a nursing infant. You should tell your doctor if a child is breastfed.Jay-Phyl is not recommended for children younger than six years of age.

How to take Jay-Phyl?

Do not take this medicine in larger or smaller amounts or for longer than recommended. Take this medication only as prescribed. Do not exceed the recommended dosage or take it for a longer time. Use a medicine cup or spoon to measure liquid medicines. Ask your pharmacist if you don't have a device for measuring doses.

If you have an upset stomach, take Jay-Phyl along with your meal. While taking this medication, drink extra fluids in order to loosen congestion and lubricate the throat. Store away from moisture, heat, and light at room temperature.

What happens if I miss the dose?

As soon as you recall, take the missed dose. If your next scheduled dosage is approaching, skip the missed dose. You should not take more medicine to compensate for a missed dose.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

Overdose symptoms include agitation, vomiting, extreme thirst, and ringing in the ears. sweating. Feeling hot. Slow or irregular heartbeat.

What should be avoided?

Before using any cold or cough medicine, consult your doctor or pharmacist. Many combination medicines contain guaifenesin. You can get too much guaifenesin by taking certain products in combination.

Interaction with other drug

Other drugs, such as vitamins and herbal products, may also interact with dyphylline or guaifenesin. Inform your healthcare providers of all the medicines you are taking and those you plan to take.