What is Elaprase?
Elaprase is an intravenous infusion used to manage symptoms associated with Hunter's syndrome (also referred to as mucopolysaccharidosis; MYOO-koe-pol-ee-SAK-a-rye-DOE-sis). Idursulfase is an enzyme found in nature that some sufferers lack due to an inherited disorder. Elaprase can replace this deficient enzyme. Hunter syndrome is an illness of metabolism in which the body does not have the enzyme that is required to break down proteins and sugars. These substances may build up within the body, leading to the growth of organs, abnormal structures of bones, changes to the facial appearance, breathing issues, heart issues, loss of vision, and changes in physical or mental capabilities.Elaprase could improve the ability to walk for those suffering from this disorder. But it isn't the cure for Hunter syndrome.
Side effects of Elaprase
Certain side effects can be experienced in the course of an Elaprase infusion or within 24 hours afterward. Seek medical attention immediately in the event that you exhibit symptoms that you are experiencing an allergic reaction. Elaprase Feeling like you're going to pass out or have hives; difficulty breathing or having seizures (convulsions); and swelling of your lips, face, and tongue
If you experience the reaction of an allergy to Idursulfase, you will be monitored closely after receiving the medicine again.
Common Elaprase adverse reactions could include:
- Vomiting, diarrhea;
- Headache;
joint pain or muscle ache; - Fever, cough;
- Itching, rash,
- Flushing (warmth of redness or tingling sensation).
This isn't a complete list of possible side effects, and other effects may also be present.Reach out to a physician for advice on any effects. Additionally, any symptoms should be reported directly to the FDA at 1-800-FDA-1088.
Warnings
Elaprase can improve the walking abilities of people suffering from Hunter syndrome. It is, however, not a cure. Elaprase does not provide a cure for this condition.Certain side effects can occur after the infusion or up to 24 hours following the infusion. Contact a medical professional immediately when you experience any symptoms that indicate an allergy, such as feeling like you could be ill or having hives, difficulty breathing, seizures (convulsions), or swelling of your lips, face, tongue, throat, or face.There is a higher chance of developing a reaction to Elaprase in the case of a breathing problem. Consult your physician if you suffer from asthma or any other lung diseases.
Before you take this drug
You shouldn't take Elaprase in the event that you are allergic to Idursulfase.To be sure Elaprase is suitable for you, consult your doctor if you have asthma or other lung issues. A reaction that is allergic could cause unexpected breathing issues.Your name might be mentioned on a Hunter Outcome Survey while you are taking this medication. The aim of this survey is to keep track of the progress of this disorder and to track the consequences that Elaprase can have on the long-term treatment of Hunter syndrome.It isn't known if Elaprase could harm an unborn baby.Consult your doctor if you are expecting or plan to become pregnant while taking the medication.It isn't known if the idursulfase enzyme is present in the breast milk of a baby. It might not be safe to breastfeed your baby while you are taking this medication. Speak to your physician regarding any potential risks.
How to take Elaprase?
Elaprase can be administered as an injection into the vein. The healthcare professional will administer this injection, typically once per week.The drug must be administered slowly, via an IV infusion. The infusion may take three hours or more to be completed.Your physician may also prescribe additional medications to help you avoid any allergic reactions. All medications should be taken according to the directions.The medication is typically administered each week. Follow the doctor's prescriptions.Your doctor will examine your performance frequently during the time you're taking this medication.
Details on dosage
Usual Adult Dose for Mucopolysaccharidosis Type II:
0.5 mg/kg by intravenous infusions once per week
Comments:
It has been proven to increase the capacity to walk.
An approved indication: For patients suffering from Hunter Syndrome (mucopolysaccharidosis II [MPS II]).
Usual Pediatric Dose for Mucopolysaccharidosis Type II:
16 months and more 0.5 mg/kg IV infusions once per week
Comments:
It has been demonstrated to improve the walking ability of patients aged 5 years and over.
There is no data to demonstrate any improvement in the symptoms of disease or long-term clinical outcomes for patients aged 16 months to 5 years old. However, the spleen volume decreased similarly to patients aged 5 years or older.
Indications approved for patients with Hunter syndrome (MPS II)
What happens if I miss the dose?
Contact your doctor for advice in the event that you don't make an appointment to receive the injection of elaprase.
What happens if I overdose?
Since the medication is prescribed by a health expert in a medical environment, it is highly unlikely for an overdose to occur.
What should be avoided?
Follow your doctor's advice regarding the food or beverage.
Interaction with other drugs
Other drugs can interact with Elaprase, such as prescription and non-prescription medicines as well as vitamins and herbal products. Inform all of your health care professionals about the medicines you take currently and all medicines that you decide to stop or begin taking.
