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Generic Name: Doravirine (also known as lamivudine) and Tenofovir Disoproxil Fumarate [DO-a-VIR, LA-MIVU-e-deen, and TENS-OFOH-vir]
Drug class: antiviral combinations

What is Delstrigo?

Delstrigo is a combination of doravirine, lamivudine, and tenofovir dioproxil fumarate. The antiviral drugs lamivudine and tenofovir prevent HIV-1 from multiplying within your body.

Delstrigo can be used for HIV-1 treatment in adult and pediatric patients who weigh at least 35kg.

  • If certain criteria are met, the patient can replace his or her current antiretroviral treatment regimen.

Delstrigo does not cure HIV/AIDS.


Inform your doctor of all the medications you are taking, as well as any new ones. Delstrigo can cause interactions with many drugs. Some drugs are not recommended to be taken together. After stopping this medication, if you have ever had hepatitis B, it could become active again or worsen. For several months, you may require frequent liver function testing.

Before you take this drug

Delstrigo should be avoided if the user is allergic to lamivudine or doravirine. Several drugs may interact with each other and have dangerous side effects. Delstrigo should never be taken with certain drugs. If you've taken any of these medicines within the last 4 weeks, your doctor might change the treatment plan.

  • Enzalutamide;
  • Mitotane;
  • Rifampin;
  • Rifapentine;
  • John's wort;
  • Seizure medicine: carbamazepine, phenobarbital, phenytoin, or oxcarbazepine.

Tell your doctor about any of the following to ensure that delstrigo will be safe for you:

  • Hepatitis b;
  • Kidney disease
  • Bone problems include a fractured bone or osteoporosis.

Delstrigo may increase your risk of breaking a bone. Speak to your doctor about ways you can maintain bone health. Use your medication properly to manage your infection. HIV may be transmitted to the baby if it is not treated during pregnancy. You may have your name listed in a registry that tracks the effects of antiviral medicines on children. Breastfeeding is not recommended for women with HIV/AIDS. The virus can be transmitted to your child even if it is not born with HIV. Delstrigo cannot be used by those who are under 35kg (77 lbs).

How to take Delstrigo?

Delstrigo should be taken exactly as directed by your physician. Read all the instructions on the prescription label. You can take the medication with or without eating. You may also need to take doravirine, or pifeltro (doravirine), about 12 hours following the time you took Delstrigo. Do not forget to follow your doctor's instructions. Read all the instructions and medication guides that you are given. You should not alter your dosage or schedule of medication without consulting your doctor. Each person living with HIV must be under the supervision of a physician. You may need to undergo blood or urine tests so that your doctor can ensure you are not suffering from any conditions that would make it unsafe for you to use this medication. Your doctor may need to test your bone mineral density. Keep Delstrigo at room temperature and away from heat or moisture. Store the tablet in its original container with the moisture-absorbing preserver. Don't put them in a pillbox for daily use. This medicine may make the hepatitis B virus active again or worsen it in the months following your last dose. You might need to have frequent liver function testing while taking this medication and even for several months following your last dose.

Details on dosage

Dosage is normal for HIV-1 infection in adults and children (over 35 kg). Take 1 tablet once daily, orally. As an antiretroviral complete regimen for HIV-1-infected patients who have never received antiretroviral therapy or meet certain criteria to change from another antiretroviral regime.

What happens if I miss the dose?

If you are almost due for the next dose, skip the missed oneNever take more than one dosage at a given time.

Refill your prescription before it runs out. If you skip doses, your virus may become resistant to the medication.

What happens if I overdose?

Call our poison help line immediately on 1-800-222-1222 if you suspect poison exposure and seek emergency medical assistance immediately.

What should be avoided?

If your doctor prescribes restrictions regarding food, beverages or activities for you to follow, be sure to follow his or her orders carefully.

Side effects of Delstrigo

If you experience any of the following symptoms of an allergy to Delstrigo, seek immediate medical attention: itching, difficulty breathing, swelling in your lips, face, throat, or tongue.

If you experience:

  • Urinating more than normal or less often;
  • Increased thirst
  • New or worsening pain in the bones
  • Muscle pain or weakness
  • You may experience pain in the arms, legs, hands, and feet.

Doravirine and lamivudine affect the immune system. This can cause side effects, even weeks or months later. You should tell your doctor about:

  • Symptoms of an infection: fever, sweats at night, swelling glands, cold sores, and other signs such as coughing or wheezing. Diarrhea. Weight loss.
  • Problems with speech or swallowing; problems in balance, eye movements, or weakness
  • Impotence, menstrual change, swelling of the neck (enlarged thyroid),

Delstrigo may cause side effects such as:

  • Nausea;
  • Dizziness;
  • Strange dreams.

There may be other side effectsCall your healthcare provider for medical advice related to side effects. Report any incidents directly by calling the FDA at 1-800-FDA-1088.

Interaction with other drug

Delstrigo may harm your kidneys if you are also taking certain medications for cancer, infections, osteoporosis transplant rejection, bowel problems, high blood pressure, pain, arthritis, and Advil.

Inform your doctor of all other medications you are taking, including:

  • If you've taken rifabutin in the last 4 weeks, or if it was prescribed to you before that time,

The list below is not exhaustive. There are other drugs that may have an interaction with lamivudine and doravirine. These include prescription, over-the-counter, and herbal medicines. This list does not include all drug interactions.



Prescription only

Pregnancy & Lactation

CSA Schedule*
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