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What is Zontivity?

Zontivity can prevent blood platelets from adhering to each other and forming an encapsulated blood clot. Unwanted blood clots could be a result of certain blood vessels or heart ailments.

Zontivity can be used to reduce the chance of a heart attack or heart-related problems that are serious in those who have experienced an attack on their heart or blood vessel disease that impacts circulation within the arm or legs.Zontivity may be combined with aspirin or clopidogrel (Plavix).


It is not recommended to make use of zontivity when you are experiencing active bleeding, such as stomach or intestinal bleeding, as well as bleeding from a brain injury or are a victim of stroke (including "mini-stroke"), bleeding in your brain, or an increase in pressure inside your skull.

Zontivity raises the chances of bleeding, which could be fatal or life-threatening. Call your doctor or seek medical attention in an emergency when you notice bloody or tarry stools, bloody or brown urine, bleeding that isn't stopping, or vomit that appears similar to coffee grinds.

Before you take this drug

It is not recommended to make use of zontivity. If you have an allergy to vorapaxar or suffer from:

  • Active bleeding;
  • Abdominal bleeding or stomach;
  • Bleeding from your head.
  • An underlying stroke history;
  • An underlying past history of an attack of transient ischemic attack (TIA), also known as "mini-stroke"; or
  • A history of bleeding in your brain or pressure in the skull.

The use of Vorapaxar can increase the chance of bleeding, which could be life-threatening or fatal, particularly if:

  • If you suffer from a bleeding disorder or blood clotting disorder, such as hemophilia.
  • You're an older adult.
  • You are underweight.
  • You have kidney or liver disease.
  • If you are taking blood thinners (Warfarin, Coumadin, or Jantoven),
  • You may take certain antidepressants (Celexa, Paxil, Cymbalta, Effexor, and others). You may take certain antidepressants (Celexa, Paxil, Cymbalta, and others).
  • You take medication known as an NSAID (nonsteroidal anti-inflammatory medication) like aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac (also known as indomethacin), diclofe, and more.

To ensure that Zontivity is appropriate for you, be sure to inform your physician if you've recently undergone any heart procedures, for example:

  • The heart bypass procedure (coronary bypass graft to the artery, also known as CABG);
  • Angioplasty (a catheter is used to insert an "stent" in a blood vessel to unblock the artery that has been narrowed or blocked) as well as
  • Coronary angiography (a special dye is injected into blood vessels, which allows the coronary arteries to be visible on an x-ray).

Vorapaxar could cause harm to a baby who is not yet born. Use effective birth control to stop pregnancy and inform your doctor if you're pregnant.

It is not recommended to breastfeed during the use of Zontivity.

How to take Zontivity?

Zontivity is usually prescribed every day, once. Follow the instructions on your prescription label and go through all medication guides or instructions.You can take Zontivity with or without food.It is possible to take aspirin or clopidogrel (Plavix). Follow the doctor's advice attentively.

If you require surgery or any other dental procedure, inform the dentist or surgeon prior to the time of surgery that you're using Zontivity. It is possible that you will need to stop taking the medication for a brief period of time to avoid bleeding.It is not recommended to stop taking this medication suddenly. A sudden stop can cause your condition to get worse.

Zontivity may have long-lasting effects on your body. It is possible that you will continue to bleed often for a period of four weeks after stopping taking this medication.Storage at room temperature, far from heat and moisture. Store the tablets in the original container together with the package or container of moisture-absorbing preservative.

Details on dosage

Usual Adult Dose for Thromboembolic Disorder:

2.08 mg taken orally, daily, in combination with or without food
Comments: Use in conjunction with aspirin or clopidogrel.
Uses: To reduce heart attacks caused by thrombosis in patients who have had an underlying history of myocardial injury (MI) or those with peripheral arterial disease (PAD).

Usual Adult Dose for Peripheral Arterial Disease:

2.08 mg taken orally, daily, without or with food
Comments: Use in conjunction with aspirin or clopidogrel.
Applications: To decrease the risk of thrombotic cardiovascular events for patients who have had a history of myocardial infarction (MI) or those with an arterial condition known as peripheral arterial disease (PAD).

What happens if I miss a dose?

Do not take the medicine for as long as you are able, but do not take your missed dose if you are close to the time of the next dose. Don't take two doses at a time.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

Avoid this

Follow your doctor's advice regarding food, drinks, or any activity.

Side effects of Zontivity

Get immediate medical attention. If you are experiencing symptoms that indicate an allergy, Zontivity These include hives, breathing difficulties, and swelling of your lips, face, and tongue.

See your doctor right away. If you are suffering from:

  • A feeling of lightheadedness, as if you're about to pass out.
  • Bleeding or easy bruising (nosebleeds or bleeding gums);
  • Brown or red urine, bloody or tarry stools that cough up blood, or vomit that appears like coffee grounds
  • Any bleeding that does not stop;
  • Low red blood cells (anemia): pale skin, unusual fatigue, feeling lightheaded or short of breath, cold feet and hands,
  • Indications of symptoms of a stroke in the form of sudden numbness or weakness (especially on the opposite part of your body) or a sudden, extreme headache and slurred speech. Difficulties with balance or vision.

Common zontivity has side effects that could include:

  • Bleeding;
  • Anemia;
  • Depression

This isn't a complete list of possible side effects, and other side effects could occur. Contact your doctor to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

There are times when it's not recommended to take certain medications together. Certain medications can alter your blood levels, as can other drugs that you are taking. This could create side effects or render the drugs less effective.

Other medications can interfere with Vorapaxar. This includes prescription and non-prescription medicines, vitamins, and herbal products. Discuss with your doctor your current medications as well as any medications you are about to start or stop taking.



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