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Glecaprevir and pibrentasvir

Generic name: glecaprevir and pibrentasvir [glec-A-pre-vir-and-pi-BRENT-as-vir]
Brand name: Mavyret
Dosage forms: oral pellet (50 mg-20 mg), or tablet (100 mg-40 mg).}
Drug class: antiviral combinations

What is Glecaprevir and pibrentasvir?

Glecaprevir-pibrentasvir combination is an antiviral medication used to treat chronic hepatitis C among people with HCV genotypes 1, 2, 3, 4, or 5.Glecaprevir and pibrentasvir are usually prescribed when other treatments fail.This medication guide does not list all possible uses for glecaprevir or pibrentasvir.

Side effects of Glecaprevir and pibrentasvir

If you experience any of the following symptoms of an allergic reaction, seek immediate medical attention hives, difficulty breathing, swelling of your lips, face, tongue, or throat.

In some cases, pibrentasvir and glecaprevir can cause liver damage. Contact your doctor immediately if you experience symptoms like:

  • Right-sided upper abdominal pain
  • Vomiting and loss of appetite.
  • Feeling confused, fatigued, or light-headed is a common symptom.
  • Easy bruising and bleeding; vomiting of blood
  • Diarrhoea, black or bloody stools
  • Dark urine
  • Yellowing of the skin or eyes.

Side effects of glecaprevir or pibrentasvir include:

  • Headache

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.


If you are taking atazanavir, rifampin, or both, you should avoid using glecaprevir or pibrentasvir.You may experience a reactivation or worsening of your hepatitis B after stopping glecaprevir and pibrentasvir. You may require frequent liver function testing for several months.

Before you take this drug

This medicine should not be used if you have an allergy to pibrentasvir or glecaprevir.

  • You have liver disease.
  • You can also take rifampin or atazanavir.

Inform your physician of any of the following issues:

  • Hepatitis B;
  • Other liver diseases other than hepatitis
  • A liver or renal transplant is possible.
  • HIV (human immunodeficiency virus);
  • An opioid addiction or a history of injecting drugs.

Inform your doctor if you are pregnant or nursing.Glecaprevir or pibrentasvir shouldn't be given to children younger than three years of age.

How to take Glecaprevir and pibrentasvir?

You will be tested by your doctor to ensure that you are not suffering from any conditions that would make it unsafe for you to use glecaprevir or pibrentasvir.Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label.Do not suddenly stop taking glecaprevir or pibrentasvir. This could make it harder for you to be treated with hepatitis C antibiotics.Read all the medication guides and follow all instructions for hepatitis C treatment. You should not stop taking a medication or change the dose without consulting your doctor. Everyone with hepatitis should be under the care and supervision of a physician.You may need to have frequent liver function tests while taking glecaprevir or pibrentasvir and for several months after your last dose. You may require frequent liver function testing while taking glecaprevir or pibrentasvir and for several weeks afterward.Refrigerate this medication at room temperature, away from heat and moisture sources.

What happens if I miss the dose?

If you miss a dose by more than 18 hours, you should use the medication as soon as possible. Use only one dose at a time.

What happens if you overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

The use of glecaprevir or pibrentasvir does not stop the spread of your illness. Share razors and toothbrushes. Do not engage in unprotected sexual activity. Speak to your doctor about the best ways to prevent HCV from being transmitted during sex. Even healthy people should never share syringes or needles.

Interaction with other drug

It is sometimes not safe to take certain medications at the same time. Some drugs may affect the blood levels of drugs that you are taking, increasing side effects or making them less effective.Some drugs shouldn't be taken together with glecaprevir or pibrentasvir. Inform your doctor of all the medicines you take. Included are prescription and over-the-counter medicines, vitamins, and herbal products. This list does not include all possible interactions.




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