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Ertugliflozin and Sitagliptin

Generic name: ertugliflozin and sitagliptin [ER-too-gli-FLOE-zin-and-SI-ta-glip-tin]

Brand name: Steglujan
Oral tablet: 15 mg–100 mg; 5 mg–100 mg
Combinations of anti-diabetic drugs

What is Ertugliflozin and Sitagliptin?

Ertugliflozin combined with sitagliptin improves blood sugar control in adults with type 2 diabetes mellitus. The combination of ertugliflozin and sitagliptin does not treat type 1 diabetes.This medication guide does not list all possible uses of sitagliptin and ertugliflozin.

Side effects of Ertugliflozin and Sitagliptin

If you experience symptoms of an allergic reaction, such as hives, difficulty breathing, swelling on your face or in your throat, or a severe reaction to your skin (fever or sore throat with burning, pain in the eyes, or skin rash, which is red or purple and blisters or peels), seek emergency medical attention.If any of these symptoms appear, seek medical assistance immediately. These symptoms can get worse very quickly.

Ertugliflozin or sitagliptin can cause serious side effects. If you experience:

  • Severe autoimmune reaction: itching, blisters, breakdown in the outer layer of skin;
  • New pain, tenderness, or sores or ulcers in your feet or legs;
  • You may experience severe pain or persistent joint pain.
  • Little or no urination
  • Ketoacidosis is characterized by nausea and vomiting. Other symptoms include stomach pain, confusion, or unusual drowsiness.
  • Symptoms of dehydration: dizziness, weakness, and feeling like you could pass out;
  • Signs of a Bladder Infection: pain or burning when urinating; increased urination or blood in the urine; fever or pain in the pelvis or lower back;
  • Symptoms of heart failure include shortness of breath, swelling of your legs and feet (even when lying down), and rapid weight gain.
  • Symptoms of pancreatitis include severe abdominal pain that may spread to the back and cause nausea or vomiting.

Some side effects are more common in older adults.

Some of the common side effects associated with ertugliflozin or sitagliptin include:

  • Urinating more than usual
    diarrhea and an upset stomach.
  • Headache
  • Cold symptoms like stuffy noses, sneezing, and sore throats.

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.


If you experience symptoms, call your doctor immediately. : severe abdominal pain that spreads to the back and may include nausea or vomiting.

Ertugliflozin or sitagliptin may cause severe infections of the vagina or penis in rare cases. Seek medical attention immediately if there is any burning, itching, or discharge, pain or tenderness around the genital area or the rectal region, swelling or redness, or fever.

Before you take this drug

This medicine should not be used if:

  • If you have severe kidney problems or end-stage renal disease, dialysis may be necessary.

Tell your doctor about any of the following:

  • Diabetic ketoacidosis;
  • Liver or kidney disease
  • A bladder infection, or urination issues;
  • Surgery for pancreas problems
  • A diabetic ulcer, or an amputation.
  • High or low blood pressure?
  • Blood circulation problems in the legs, particularly
  • Nerve damage in your legs;
  • Gallstones;
  • High triglycerides
  • Alcoholism;
  • Type 1 diabetes
  • If you're eating less or if your diet has changed, you may be on a salt-free diet.

You should follow your doctor's instructions when using this medication during pregnancy.Ertugliflozin or sitagliptin should not be used during the second and third trimesters of pregnancy.This medicine should not be used while breastfeeding.Anyone younger than 18 is not allowed to use Ertugliflozin or Sitagliptin.

How to take Ertugliflozin and Sitagliptin?

Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed.Take ertugliflozin or sitagliptin either with food or without.If you have diarrhea or vomiting, or if you're perspiring more often than normal, call your doctor.Inform your doctor of any planned surgeries.You will have to check your blood sugar often and may need to test for ketones in your urine. Ertugliflozin may cause life-threatening ketoacidosis. If your blood sugar level is normal but a urine test shows ketones, you should contact your doctor.You might feel very hungry or dizzy. You may also be confused, anxious, irritable, or shaky. If you want to treat hyperglycemia quickly, consume or drink sugary foods or drinks (fruit juices, crackers, or raisins).In the event of severe hypoglycemia, your doctor may prescribe a glucagon injectable kit. Make sure that your family and friends are familiar with how to administer this injection if you need it in an emergency.

Watch for symptoms of hyperglycemia, such as increased thirst and urination.Stress, illness, surgery, and alcohol consumption can affect blood sugar levels. Consult your doctor before making any changes to your medication or dose schedule.Certain lab tests can produce unusual results. Inform any doctor that you use ertugliflozin or sitagliptin.Store away from moisture or heat at room temperature. Keep the original foil blister pack with the unused tablet.

Details on dosage

Adult dosage for diabetes type 2:

Initial dose: Orally, 1 tablet of ertugliflozin (5 mg/sitagliptin) once daily.
For patients who tolerate the therapy well and require additional glycemic management, they may be able to increase their dose to one tablet of ertugliflozin (15 mg/sitagliptin) taken orally once daily.
Maximum dose: ertugliflozin 15 mg/sitagliptin 100 mg per day
Patients already taking ertugliflozin should switch to a combination product at the same dose.
Before starting therapy, it is important to correct the volume depletion.
This drug is not recommended for patients with diabetes type 1, as it can increase the risk of diabetic ketoacidosis.
This drug has not yet been studied in patients who have a history of pancreatitis. It is unknown if this could increase the risk that pancreatitis will develop during treatment.
Use: To improve the glycemic level in adults with type II diabetes.

What happens if I miss the dose?

If you are almost due for your next dose, skip the missed one. Never take two doses of the same medicine at once.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

Avoid this

Avoid alcohol consumption.You may get dizzy if you stand up quickly from a seated or lying position.

Interaction with other drug

Your doctor may adjust your dose of other diabetes medications you take regularly when you begin or stop taking sitagliptin and ertugliflozin.Other drugs, such as vitamins and herbal remedies, may also affect ertugliflozin or sitagliptin. Inform your doctor of all the medicines you are taking and those that you stop or start using.



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