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Name of the Generic: Perampanel [per-AM-pa-nel].
Drug Class: AMPA receptor antagonists.

What is Fycompa?

Fycompa is an anticonvulsant medication used for the treatment of seizures that affect adults as well as children. Fycompa helps treat partial-onset seizures that could or might not progress into general seizures in those suffering from epilepsy who are four years old. Fycompa is also used along with other drugs for treating primary generalized tonic-clonic (PGTC) seizures in patients 12 years of age or older.


Certain individuals taking Fycompa have experienced severe psychotic symptoms, especially at the beginning of this medication or when adjusting dosages. Be aware of any changes in your mood or symptomatology. Get in touch with your doctor immediately if you notice any mood or behavior changes, such as personality changes, thoughts of suicide, or even thoughts of hurting someone else. Your family members and other caregivers should be aware of shifts in mood or any symptoms.

Before you take this drug

It is recommended not to utilize Fycompa if you have an allergy to perampanel. To ensure that Fycompa is appropriate for you, consult your doctor if:

  • Depression is a mental disorder or other mental health issue.
  • The thoughts of harming yourself or others.
  • Kidney or liver disease.
  • Addiction to drugs.
  • If you consume alcohol.

Certain individuals who are taking Fycompa have experienced severe psychotic symptoms, including anger or aggression, feeling angry or angry, as well as thoughts of hurting other people. These symptoms are more likely to happen at the time of your first introduction to Fycompa or when you change your dose. Your doctor should monitor your progress on a regular basis. Changes in your symptoms or mood should be monitored by family members or other caretakers. Do not begin or stop taking seizure medications during pregnancy without seeking advice from your doctor. Having a seizure during pregnancy can harm both the baby and the mother. Talk to your doctor immediately if you find yourself pregnant. Fycompa could make certain contraceptives less efficient. Consult your physician about an alternative to hormonal birth control (condom diaphragm or diaphragm with spermicide) to stop pregnancy. If you're expecting, then your name might be included on an OB-GYN registry to track the impact of perampanel on the baby. It might not be safe to breastfeed while taking Fycompa. Consult your physician regarding any potential risks.

How to take Fycompa?

Fycompa is usually taken before going to bed. Follow the directions on the prescription label and review all medication manuals or instruction sheets. Your doctor may alter your dosage. Perampanel could be a drug that can cause addiction. Intoxication can result in dependence, overdose, or even death. Keep the medication in a safe place so that others aren't able to access it. Giving away or selling this medicine is against the law.

Make sure to shake off the oral suspension (liquid) prior to taking the dosage. Make use of the dosing syringe supplied or a dosage-measuring device (not the kitchen spoon). Do not stop taking Fycompa immediately, even if you feel good. The abrupt stop could trigger seizures. Follow the advice of your doctor about increasing your dosage. Storage at room temperature, far from heat and moisture. Avoid freezing. Dispose of any liquid medicine within 90 days of the first time you opened the bottle. Make sure you keep track of your medication. It is important to be aware if someone is taking it incorrectly or without a prescription.

Details on dosage

Usual Adult Dose of Fycompa for Seizures:

Absence of enzymes that cause AEDs:
Initial dose: 2 mg every night. The dosage can be increased to 2 mg daily orally in small increments, but not more frequently than once a week.
Maintenance dosage: 4 to 12 mg once a day, orally at night.
Maximum dosage: 12 mg taken orally every day at bedtime.
In the presence of enzymes that induce AEDs (including carbamazepine and phenytoin) and oxycarbazepine:
Initial dosage: 4 mg taken orally each day before bedtime. Patients should be monitored to determine their response. Studies have shown a significant reduction in the rate of seizures in those patients. When these AEDs that induce enzymes are removed or added to a treatment regimen, the patient must be monitored for clinical response and tolerance. Adjusting the dosage of perampanel could be required.
Maximum dosage: 12 mg taken orally each day before going to bed.
Approved indication: adjunctive therapy to treat partial-onset seizures accompanied by or without secondary generalized seizures in patients suffering from epilepsy aged 12 years and over.

Usual Pediatric Dose of Fycompa for Seizures:

Greater than or equal to 12 years old: If there are no enzyme-inducing AEDs, The initial dose is 2 mg once daily, orally before bed. Dosage can be increased by 2 mg daily, orally in small increments, but not more often than once a week.

Dosage for maintenance: 4–12 mg daily, taken orally at night. Maximum dosage: 12 mg once each day before bedtime.
If you are taking enzyme-inducing AEDs (including carbamazepine and phenytoin) and oxycarbazepine for the first time, take 4 mg once a day before bedtime. Patients must be closely watched to determine if they respond. Research has shown that there is a significantly reduced impact on the rate of seizures in those patients. If these AEDs induce seizures and are removed or added to a treatment regimen, patients should be monitored for clinical response and tolerance. Adjusting the dosage of perampanel could be required.
Maximum dosage: 12 mg once every day at bedtime.
The indication that has been approved is adjunctive therapy to treat partial-onset seizures accompanied by or without secondary generalized seizures in patients suffering from epilepsy aged 12 years and over.

What happens if I miss a dose?

Do not miss the missed dose, and take the next dose at your regular time. Do not take two doses at once. Consult your physician for the appropriate treatment. If you have missed taking your Fycompa medication for more than a single day.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Avoid driving and other hazardous activities until you are aware of the effects of this medication. Dizziness or drowsiness may cause accidents, falls, or serious injuries. Consuming alcohol while taking this medication may cause unwanted side effects.

Side effects of Fycompa

Get immediate medical attention. If you are experiencing symptoms that indicate an allergy reaction, such as hives, breathing problems, or swelling of your lips, face, or tongue, Get medical attention when you experience a serious reaction to a drug that affects various parts of your body. Symptoms may include: a skin rash and fever; swelling of glands; muscle aches; extreme weakness; unusual bruising or discoloration of your eyes or skin. Inform your doctor about any new or worsening symptoms, for example, a change in your mood or behavior, anxiety, panic attacks, and sleeplessness, or if you are feeling uneasy, furious and restless, overly hyperactive (mentally and physically), or contemplating suicide or injuring yourself or others

Contact your doctor immediately. If you suffer from:

  • Severe dizziness, a spinning sensation, or feeling like you might pass out.
  • Problems with walking or a lack of equilibrium or coordination.
  • Feeling very tired or weak.
  • An accidental fall.
  • Memory problems, hallucinations, confusion, and hallucinations.

Falls that result in injury can occur more frequently among elderly patients taking Fycompa. Be cautious to avoid injuries or falls when you take this medicine.

Common Fycompa side effects can include:

  • Headache, dizziness, or drowsiness.
  • Experiencing fatigue, anxiety, or anger.
  • Nausea, vomiting, and stomach pain.
  • Bruising.
  • Weight gain.
  • Loss of coordination.

This is not an exhaustive list of all possible adverse effects. other side effects may arise. Consult your physician for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Utilizing Fycompa together with other medications that cause you to become drowsy could increase the severity of this effect. Consult your physician before taking opioids, a sleeping pill such as a muscle relaxer, or medication for seizures or anxiety. It is sometimes not recommended to take certain medications simultaneously. Certain medications can alter the blood levels of other medications you are taking, which could create side effects or render the medication less effective. Discuss with your doctor your other medications, including:

  • Birth control pill.
  • Rifampin.
  • John's wort.
  • Other seizure medications Other seizure medicines include carbamazepine, oxcarbazepine, and phenytoin.

This list isn't complete. Other drugs can be compatible with perampanel, which includes medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between drugs, which are listed here.



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