The Web Health



Generic name: hyaluronidase, pertuzumab, and trastuzumab [HYE-al-ure-ON-i-dase, per-TOOZ-ue-mab, and-tras-TOOZ-ue-mab]
Drug class: HER2 inhibitors

What is Phesgo?

Phesgo includes a mix of hyaluronidase pertuzumab and trastuzumabis. Phesgo is a treatment for cancer that is taken either by itself or in combination with other medications to treat early-stage breast cancer. Phesgo can also be used to treat breast cancer that is progressing or spreading to other regions within your organs (metastatic). Phesgo is prescribed for breast cancer only when your cancer is positive for the protein named the human epidermal growth factor receptor (HER2). The HER2 protein may speed up the growth of cancerous cells.


Phesgo could cause serious lung or heart problems that can be life-threatening. Call your doctor immediately if you notice difficulty breathing, swelling or fast weight loss, speedy or high-pitched heartbeats, or feeling lightheaded.

Do not take, in case you are expecting. Use effective birth control during treatment and for at least 7 months following the last dose.

Prior to use this drug

It is not recommended to treat with Phesgo in the event that you have an allergy to the hyaluronidase pertuzumab, pertuzumab, or trastuzumab.

To be sure Phesgo is safe for you, inform your doctor if you ever experience:

  • Congestive heart failure;
  • A cardiac attack or heart rhythm disorder
  • Uncontrolled blood pressure;
  • An immune system that is weak, caused by chemotherapy
  • Treatment of chemotherapy with chemotherapy treatment using doxorubicin

It's possible to require an unfavorable pregnancy test prior to commencing this treatment. Do not take Phesgo when you are pregnant. It could cause birth defects or even death for an unborn infant. Make sure you use effective birth control to avoid pregnancy while using Phesgo for at least seven months following your last dose. Inform your doctor immediately in case you think you may be pregnant. In the event that you're expecting or are pregnant within seven months of being treated by this medication: Your name may be added to the registry for pregnancy to monitor how hyaluronidase affects trastuzumab, pertuzumab, and the infant. It might not be appropriate to breastfeed when using Phesgo. Consult your physician about any potential risks.

How to take Phesgo?

Phesgo is injected beneath the skin on your lower thigh. A doctor will provide you with the injection. Phesgo is typically prescribed each week for up to a year. Your physician will decide the duration of treatment by using this medication. You will be monitored closely for between 15 and 30 minutes to ensure that you don't suffer any serious reactions in response to the injection. Phesgo may have long-lasting impacts on the heart. The function of your heart may have to be monitored every six months for a minimum of two years following the last time you took your dose. At least seven months following your final dose of Phesgo, ensure that your doctor treating you for chemotherapy is aware that you've received this medication.

What happens if I miss the dose?

Contact your doctor for advice. If you do not make an appointment to see your pheso,

What happens if I overdose?

Because Phesgo is administered by a medical specialist in a medical setting, it is highly unlikely for an overdose to occur.

What should be avoided?

Follow the instructions of your physician regarding any limitations on foods, drinks, or activities.

Side effects of  Phesgo

Seek medical attention immediately when you notice signs of an allergic reaction. Phesgo such as a rash, hives, dizziness, chills, fever, nausea, vomiting, diarrhea, chest pain, difficulty breathing, swelling of your lips, face, or tongue

Phesgo can lead to serious lung or heart problems that can be life-threatening. Call your doctor immediately if you experience:

  • A new or worsening cough or breath shortness (even when you're at rest);
  • Rapid heartbeats or fast beats;
  • Extreme headache severe headache, blurred vision pain in your neck or in your ears;
  • Swelling of your lower or face;
  • Rapid weight loss (more than 5 pounds gained in just 24 hours);
  • A lightheaded sensation, similar to when you're about to pass out.
  • Lower white blood cell count (fever, mouth sores, and skin sores) irritation of the throat, cough, difficulty breathing, or
  • The red blood cell count is low (anemia); pale skin; unusual fatigue; feeling lightheaded or short of breath; cold feet and hands.

The treatment you receive for cancer could be delayed or completely stopped in the event of certain adverse consequences.

Common Phesgo advere effects could be:

  • Nausea, diarrhea;
  • Anemia;
  • Being tired or weak;
  • Hair loss;
  • The rash o
  • Numbness, tingling, or burning pain in your hands and feet

This is not a comprehensive list of possible side effects, and others could happen. Contact your physician to seek medical advice on the effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Other medications can influence Phesgo. Other medications can affect Phesgo, including medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your physician the medicines you are currently taking and any medication you begin or stop taking.