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Zydelig

Generic name: Idelalisib eye-DEL-a-LIS-ib eye-DEL-a-LIS-ib eye-DEL-a-LIS-ib
Drug class: PI3K inhibitors

What is Zydelig?

Zydelig is a medication for cancer that blocks the spread and growth of cancerous cells within the body.Zydelig is a component of the drug rituximab (Rituxan) to treat chronic lymphocytic leukemia and certain kinds of lymphoma.

Zydelig can be administered in the event that at least two other treatments for cancer didn't work or ended their effectiveness.Zydelig is approved by the US Food and Drug Administration (FDA) on an "accelerated" basis to treat lymphoma. In clinical studies, a few people were able to respond to this medication. However, further research is required.

Warnings

Zydelig could cause severe harm to the lungs, liver, and intestines. Certain of these issues could result in death-threatening complications. Consult your doctor immediately if you experience abdominal pain, bleeding, easy bruising, or dark urine, a yellowing of your eyes or skin, wheezing, coughing, shortness of breath, chills, fever, increasing stomach pain, or vomiting.

You could experience severe or even life-threatening diarrhea when you take Zydelig. Inform your doctor immediately when your stool movements increase by more than 6. Zydelig could also trigger a perforation (a tear or a hole) within the intestines. Consult your physician immediately if you notice diarrhea that is bloody or watery. If you experience bloody or tarry stool or have a bloody cough that appears as coffee grounds,

Before you take this drug

It is possible that you will not be able to take Zydelig in the event that you've experienced a severe skin reaction to any drug.

To be sure Zydelig is suitable for you, inform your doctor if you've ever experienced:

  • Liver disease;
  • Lung disease;
  • Perforations (a tear or hole) inside the intestines

Idelalisib could harm an unborn child in the case that the father or mother uses this medicine.

  • If you're female, do not use Zydelig in case you are expecting. It is possible that you will need an unconfirmed pregnancy test prior to taking this medication. Make sure you are using effective birth control to avoid the possibility of pregnancy while using this medication and for at least one month following your last dose.
  • If you're male, use effective birth control when your partner can get pregnant. Use birth control for at least three months following your last dose.
  • Inform your doctor immediately when you notice a pregnancy when both the mother and father are taking Zydelig.

Avoid breastfeeding during the course of this medicine and at least one month after the last dose.Zydelig is not a product that has been approved to be used by anyone younger than 18 years of age.

How to take Zydelig?

Zydelig is typically taken two times each day. Follow the directions on the prescription label and go through all medication guides or instructions sheets.Zydelig is a medicine that can be taken in combination with food or not.Take the tablet in one swallow, and don't crush, chew, or break it.

There is a chance that you will experience severe or life-threatening diarrhea when taking Zydelig. Inform your doctor immediately whenever your stool movements increase by more than 6.It is possible that you will require frequent medical tests to make sure the medication isn't causing negative consequences. Your treatment for cancer could be delayed based on the results.

Don't stop taking Zydelig without consulting your physician.Keep this medicine in its original container, at room temperature, and away from heat and moisture.

Dosing information

Usual Adult Dose of Zydelig for Non-Hodgkin's Lymphoma:

150 mg orally, 2 times per day, until progression of the disease or unacceptably toxic
Comments:
This medication can be taken without or with food.
Tablets should be taken whole.
If the patient fails to take the dose within 6 hours from the time the dose is normally taken, the patient must get the missed dose as fast as they can and then resume their regular dosing schedule.
If a patient has missed the dose for more than six hours, then the patient shouldn't do the missed dose but simply return to the normal dose schedule.
Uses:
In combination with rituximab for the treatment of patients suffering from chronic lymphocytic leukemia that has relapsed (CLL) who require the use of rituximab, this is not an appropriate treatment due to the presence of other comorbidities.
Treatment of patients suffering from relapsed non-Hodgkin lymphoma of the follicular (FL) that have had at least two previous treatment regimens
The treatment of patients suffering from relapsed small lymphocytic cancer (SLL) that have had at least two prior therapies for the system

Dose for Chronic Lymphocytic Leukemia:

150 mg taken orally twice every day until the progression of disease or unacceptably toxic
Comments:
This drug can be taken without or with food.
Tablets should be swallowed whole.
If a patient is unable to take the dose within 6 hours of when it is typically taken, the patient must get the dose missed as quickly as possible and then resume the regular schedule of dosing.
If a patient is missing a dose for more than six hours, then the patient shouldn't miss the dose and simply return to the normal dosage schedule.
Uses:
In conjunction with rituximab to treat patients who have chronic lymphocytic leukemia that has relapsed (CLL) and who require it, it is the only appropriate treatment due to the presence of other comorbidities.
The treatment of patients suffering from relapsed follicular lymphoma non-Hodgkin's (FL) that have had at least two previous treatments systemically
Treatment of patients suffering from relapsed small lymphocytic cancer (SLL) with relapsed ALL who've had at least two prior therapies for the system

Usual Adult Dose of Zydelig for Lymphoma:

150 mg orally, 2 times every day, until the progression of disease or toxicity is unacceptable.
Comments:
This drug can be taken without or with food.
Tablets should be taken whole.
If a patient is unable to take the dose within 6 hours of when the dose is normally administered, the patient should be sure to take the dose missed as soon as they can and then resume their regular schedule of dosing.
If a patient has missed a dose for more than six hours, it is advised that the patient not take the missed dose but just resume their usual dosage schedule.
Uses:
In combination with rituximab to treat patients who have chronic lymphocytic leukemia that has relapsed (CLL) who are candidates for the use of rituximab, this is not the best treatment due to other comorbidities.
Treatment of patients with relapsed non-Hodgkin lymphoma of the follicular (FL) that have had at least two previous treatment regimens
The treatment of patients suffering from ALL that has relapsed (SLL) with relapsed SLL who've had at least two prior therapies for the system

Do I be concerned if I miss a dose?

You should take the medicine as fast as you are able, but avoid any missed dosage if you have been more than 6 hours behind on the dose. Don't have two doses at one time.

What will happen if I take excessively?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any restrictions regarding drinks, food, or activities.

Side effects of Zydelig

See a doctor immediately when you notice symptoms or warnings of a reaction that is allergic to Zydelig (hives, breathing difficulties, and swelling of your throat or face) or an intense skin reaction (fever and throat soreness, eye burning, irritation, and the skin is red or purple with peeling and blisters).

Get medical attention when you experience a severe drug reaction that could affect various parts of your body. Symptoms may include the following: a skin rash and fever; swelling of the glands; muscle pains; abnormal bruising; severe weakness; or a discoloration of your eyes or skin.

Zydelig can cause serious damage to your lungs, liver, and intestines. There is a possibility of having serious or life-threatening diarrhea or a perforation (a tear or hole) within your intestinal tract. Certain of these conditions could result in serious complications.

See your doctor right away. If you suffer from:

  • Severe diarrhea, an increase in the amount of stool per day;
  • Simple bleeding, unusual bruising, red or purple spots on your skin
  • Digestive problems: a worsening stomach ache and chills, fever, vomiting, and stomach pain;
  • Liver issues: stomach discomfort, weight loss, and dark urine jaundice (yellowing of the eyes or skin);
  • Lung conditions with a worsening cough wheezing, cough with mucus, or a shortness of breath.
  • Low white blood cells; fever; mouth sores; skin sores; sore throat

The treatment you receive for cancer could be delayed or completely stopped in the event of certain adverse consequences.

Common Zydelig side effects may include:

  • Nausea, stomach pain, diarrhea;
  • Fever, cough, lung problems;
  • Low white blood cells;
  • Abnormal tests for liver function;
  • It can be a rash
  • Feeling exhausted.

This is not an exhaustive listing of all the side effects. Other effects may also be present. Consult your physician for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

It is sometimes not advisable to use certain medicines in combination. Certain medications can alter the blood levels of other medications you are taking, which could cause more side effects or make the drugs less effective.

Other medications can be incompatible with idelalisib. This includes medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your doctor about your current medications as well as any medications you are about to start or stop taking.

DRUG STATUS

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Prescription only

Pregnancy & Lactation

CSA Schedule*

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