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Pazopanib

Generic Name: Pazopanib [paz-OH-pa-nib]
The Brand Name is Votrient.
Dosage Format: Oral tablet (200 mg)
Drug Class: VEGF/VEGFR inhibitors

What is Pazopanib?

Pazopanib can be used to treat advanced kidney cell carcinoma (kidney cancer).Pazopanib can also be employed for treating soft tissue sarcoma (a tumor that may form in or around muscles, joints, tendons, organs, or blood vessels). Pazopanib is typically prescribed when other treatments have not worked.Pazopanib is also employed for other purposes that are not covered in this guideline.

Side effects of Pazopanib

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as hives, difficulty breathing, and swelling of your lips, tongue, throat, or face.

Pazopanib can cause life-threatening blood clots to form in the tiny blood vessels within your organs, like your kidneys or brain. Seek medical help immediately if you notice symptoms of this disease, including symptoms like fever and fatigue, decreased urinary frequency, bruising, or nosebleeds.

Pazopanib could cause serious adverse effects. Contact your physician immediately in the event that you experience:

  • Extreme chest pain, headache, and confusion. You may also feel a pain in your neck or ear.
  • A seizure;
  • Continuous, persistent cough or breathing issues;
  • Bleeding or bruising that is unusual;
  • Any surgical or other wound that isn't healed;
  • Heart issues: swelling in the chest, rapid weight gain, breathlessness, and racing heartbeats; a feeling of flutter in your chest; sudden dizziness (like you're going to faint);
  • Heart attack symptoms: chest pressure or pain; pain that spreads into your shoulder or jaw; nausea; sweating;
  • Liver issues: nausea, vomiting, stomach pain, nausea, vomiting, loss of appetite, fatigue, dark urine, and jaundice (yellowing of the eyes or skin).
  • Indications of symptoms: fever and runny nose the sore throat pain in the body, irritation to the skin, and burning sensation when you go to the bathroom;
  • Symptoms of stomach bleeding: stomach swelling or pain, bloody or tarry stools, coughing up blood, or vomit that appears like coffee grounds.
  • Symptoms of signs of stroke or blood clot, sudden weakness or numbness or severe headache, slurred speech, chest pain, rapid shortening of breath, discomfort or a chill feeling in the leg or arm;
  • Signs of tumor cell breakdown—tiredness, muscle cramps or spasms, tingling, vomiting, diarrhea, fast or slow heart rate, little or no urination

Liver problems are likely for people who are older than 65.

Common adverse effects of pazopanib could include:

  • Nausea, vomiting, diarrhea, and stomach pain;
  • Loss of appetite; reduction in weight;
  • Trouble breathing
  • Tumor pain, bone pain, muscle pain;
  • Headache, fatigue;
  • Modifications in skin or hair color Changes in skin color or hair
  • Changes in your perception of your taste.

This isn't an exhaustive listing of all adverse negative effects. Additional effects could also be observed. Talk to your physician for medical advice about the effect. If you experience any adverse negative effects to the FDA by calling 1-800-FDA-1088.

Warnings

Pazopanib could cause serious or even life-threatening liver issues. You will need regular blood tests to monitor your liver's health.

Contact your physician immediately if you experience nausea, vomiting, or stomach pain.

Before you take this drug

Speak to your doctor if you are ever diagnosed with:

  • Liver disease;
  • Heart diseases, cardiac rhythm disorders, the long QT syndrome,
  • Hypertension;
  • Stroke or blood clot;
  • Headaches, seizures, or vision problems;
  • A thyroid disorder
  • Kidney disease;
  • Perforations (a tear or hole) in your stomach or intestines
  • A fistula (an abnormal passageway) in the stomach or intestines of your body;
  • Abdominal bleeding, if you've been coughing up blood within the last 6 months,
  • A procedure (recent or scheduled).

You might need to undergo an unfavorable pregnancy test prior to beginning this treatment.

Men and women who take pazopanib need to use birth control to stop the birth of a baby. Pazopanib can harm an unborn baby if the mother or father are taking this medication. Continue using the birth control for at least 2 weeks following the last dose.

If you're a man who has a partner who is or may become pregnant, make sure you use condoms after having undergone a vasectomy.

Contact your physician immediately. If you become pregnant when one of the mothers or fathers is taking pazopanib,It is not recommended to breastfeed while you take pazopanib or for at least two weeks following the last dose.

How to take Pazopanib?

Follow the directions on the label of your prescription and read the medication guide or instructions sheets. The doctor might change your dosage. Follow the medication exactly as prescribed.

Use pazopanib when you have an empty stomach at least an hour prior to or two hours after the meal.Take the tablet in one swallow and make sure you don't chew, crush, or break it.Pazopanib is known to cause severe or life-threatening liver problems and elevated blood pressure. It is recommended to have regular medical tests.

If you are having surgery, inform your surgeon in advance that you're taking pazopanib prior to surgery. It is possible to stop taking the medication until at least 7 days prior to and two weeks following your surgery. Consult your physician before resuming the pazopanib medication following surgery.

Keep at room temperature, free of heat and moisture.

Details on dosage

Usual Adult Dose for Renal Cell Carcinoma:

800 mg taken orally every day for a period of time until the disease progresses or becomes unacceptably toxic.
Uses:
Advanced renal cell cancer (RCC)
Advanced soft tissue tumors (STS) in combination with chemotherapy prior

Usual Adult Dose for Soft Tissue Sarcoma:

800 mg orally, once a day, for a period of time until the disease progresses or becomes unacceptably toxic.
Uses:
Advanced cancer of the kidney (RCC)
Advanced soft tissue sarcoma (STS) that has been treated prior to chemotherapy

What happens If I miss a dose?

Utilize the medicine as soon as you are able, but do not miss your missed dose if the scheduled dose is due to be taken in less than twelve hours. Do not take two doses at once.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Grapefruit can interact with pazopanib and result in undesirable negative side effects. Do not use products made from grapefruit.

Talk to your doctor before taking an anti-inflammatory. Avoid taking an antacid for several hours prior to or after taking the drug pazopanib. Avoid taking stomach acid reducers (Axid, Nexium, Pepcid, Prevacid, Prilosec, Protonix, Tagamet, Zantac, and Zegerid) while taking pazopanib.

Interaction with other drugs

Discuss with your doctor any other medications you take, including:

  • An antibiotic;
  • An antidepressant
  • Cholesterol medication that includes simvastatin (Zocor, Vytorin Juvisync, Simcor);
  • Heart rhythm medication
  • HIV as well as AIDS medication and
  • Stomach acid-reducing agents like Nexium, Prilosec, Tagamet, and others.

This list isn't exhaustive. Other medications can interfere with pazopanib. This includes prescription and over-the-counter medicines, vitamins, and herbal supplements. The interactions of a variety of drugs are outlined here.

DRUG STATUS

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Prescription only

Pregnancy & Lactation

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