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What is Fedratinib?
Fedratinib is a treatment for myelofibrosis in adults. Myelofibrosis is a rare form of bone marrow cancer that affects the body's ability to produce blood cells. Fedratinib can also be employed for other purposes that are not covered in this guide to medication.
Side effects of Fedratinib
See a doctor immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as symptoms of hives or difficulty breathing or swelling of your lips, face, tongue, throat, or face.
A few people taking fedratinib have been diagnosed with vitamin B1 deficiencies, which led to serious and occasionally fatal brain damage. Seek emergency medical treatment if you experience symptoms that include:
- Drowsiness, confusion, drowsiness, memory issues
- Problems with vision, eye movements, or
- Issues with coordination and muscle movements.
Fedratinib could cause serious adverse reactions. Contact your doctor immediately in the event that you experience:
- Persistent or severe nausea, vomiting nausea, vomiting persistent nausea, vomiting, or (even if you're taking medications to reduce these symptoms);
- Easily bleeding, unusually bruising red or purple spots on the skin
- Red blood cells are low (anemia)--pale skin or a feeling of fatigue that is unusual, faint or lightheaded, cold hands and feet, or
- Low white blood cell count low white blood cell counts low white blood cell counts, fever, mouth sores, wounds on the skin, painful throat, cough, difficulty breathing
It is possible to require a transfusion of blood in the event that your blood counts are too low.
Common side effects of fedratinib can include:
- Nausea, vomiting;
- Diarrhea;
This isn't a complete list of all the side effects. Other side effects could be present. Consult your physician to seek medical advice on the effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.
Similar or related drugs
Jakafi, ruxolitinib, Vonjo, pacritinib, and Inrebic
Warnings
Some patients taking fedratinib may have been diagnosed with vitamin B1 deficiencies, which led to severe as well as fatal damage to the brain. It is possible that your vitamin B1 levels should be assessed prior to and during treatment, and you might require vitamin B1 supplements.
Take immediate medical care. If you experience symptoms that include drowsiness, confusion, memory issues, vision issues, irregular eye movements, or issues in coordination and muscle movement,
Contact your physician if you're experiencing diarrhea or vomiting, even if you are taking medication, to avoid these adverse negative effects.
Prior to use this drug
Speak to your doctor if you have ever suffered from:
- the low level of platelets (also known as red blood cells).
- the liver condition;
- kidney disease kidney disease
- If you've taken the drug ruxolitinib (Jakafi),
It isn't known if fedratinib can cause harm to a baby who is not yet born. Inform your doctor if you are expecting or planning to be pregnant.
You shouldn't feed your baby while taking this medication for at least one month following your last dose.
What should I do to take fedratinib?
Follow the directions on your prescription label, and go through all medication guides or instructions. The doctor might alter the dosage. Make sure you take the medicine precisely as directed. You can consume fedratinib with or without food. Take it with a high-fat food when fedratinib is causing stomach upset. The vitamin B1 (thiamine) levels must be assessed prior to or during your treatment with fedratinib. It is possible that you will need to take a vitamin B1 supplement. You might also be prescribed other medications to treat nausea, vomiting, and diarrhea. Continue to take these medications for as long as your physician prescribes them.
Some patients taking fedratinib may have suffered from vitamin B1 deficiency, which has led to severe or even fatal damage to the brain. The levels of vitamin B1 require checking prior to or during your treatment with fedratinib. It is possible that you will need vitamin B1 supplements. Contact your physician. If you're sick and suffering from diarrhea or vomiting, even if you are taking medication to reduce these adverse effects, You can easily get malnourished as a result of vomiting or diarrhea. This can result in a deficiency in vitamin B1 levels.
Fedratinib could lower the blood cell count and impact the liver's function. Your blood needs to be checked frequently. The treatment for cancer may be delayed, depending on the results. Don't alter the dose or cease taking Fedratinib unless the advice of your physician is given. Place it in a cool, dry place free of heat and moisture.
Details on dosage
Usual Adult Dose for Myelofibrosis:
For patients who have a baseline platelet count of 50 x 10(9)/L or more:
400 mg taken orally every day
Comments:
Patients taking ruxolitinib should reduce their dose and stop taking ruxolitinib prior to beginning this medication.
Assess levels of thiamine (vitamin B1) and nutritional status prior to beginning treatment, periodically throughout treatment, and when indicated.
A high-fat diet can reduce the risk of vomiting and nausea.
Subsequent doses of this medication are subject to adjustments in dosage in accordance with the treatment with CYP450 3A4 inhibitors, renal function, previous adverse reactions, and/or levels of thiamine.
Use: To treat patients suffering from intermediate-2 or high-risk secondary or primary (postpost polycythemia vera or post-essential thrombocythemia) myelofibrosis (MF).
What happens if I miss the dose?
Don't miss the dose you missed, and take the next dose at the normal time. Don't use two doses at once.
What happens if I overdose?
Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.
What should be avoided?
Follow the instructions of your physician regarding any restrictions on your food, drink, or activities.
Interaction with other drugs
It is sometimes not safe to take certain medications in combination. Certain medications can alter the blood levels of other medications that you take, which can create side effects or render the medication less effective.
Other medications can affect fedratinib's effects, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about all the medications you currently use and any medication you begin or stop taking.