The Web Health



Name of the Generic: Pacritinib  pak-RI-tib.
Brand Name: Vonjo.
Dosage Form: Oral capsule (100 mg).
Drug Class: Multikinase inhibitors.

What is Pacritinub?

Pacritinib can be used to treat myelofibrosis in adults. Pacritinib can also be employed for other purposes that are not covered in this guideline.

Side effects of Pacritinib

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that are warning signs of an allergic response, such as difficulty breathing, hives, and swelling of your lips, face, and tongue.

Pacritinib could cause serious adverse reactions. If you have any of the following symptoms, please contact your doctor right away:

  • Bleeding, bruising, and an increase in temperature.
  • Chronic or persistent diarrhea.
  • Dizziness and lightheadedness, as if you're about to pass out.
  • Symptoms of stroke—sudden weakness or numbness, a serious headache, and slurred speech. difficulties with balance or vision.
  • Indications that a blood clot has formed inside the lung: chest pain, an abrupt and loud cough or shortness of breath, fainting, or bleeding from the chest.
  • Symptoms of a blood clot that is deep within the body, such as pain, swelling, or a warm sensation on one side of the leg.
  • Heart attack symptoms: chest pressure or pain, pain that is spreading into your shoulder or jaw, nausea, sweating.
  • Symptoms of fever, colds, sore throats, body aches, uncharacteristic hunger, fatigue, bleeding, or bruising.

Common side effects of pacritinib include:

  • Swelling of legs, ankles, and feet.
  • Nausea, and vomiting nausea and vomiting.
  • Dull skin and fatigue, feeling lightheaded or tired, and cold hands and feet.

Other side effects could occur. Consult your physician for advice regarding medical adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.


Take only according to the directions. Inform your doctor if you take other medications or suffer from any medical conditions or allergies.

Before you take this drug

Certain medications should not be used in conjunction with pacritinib. The treatment plan you are using could change when you are also using:

  • John's wort.
  • An antibiotic—clarithromycin, rifabutin, rifampin, rifapentine, telithromycin.
  • Antifungal medicine (itraconazole, ketoconazole).
  • Antiviral medication to treat HIV as well as hepatitis C—boceprevir and cobicistat, dasabuvir, elvitegravir, indinavir, lopinavir/ritonavir, paritaprevir, ombitasvir, the saquinavir drug, telaprevir, and tipranavir.
  • Cancer medicine—apalutamide, enzalutamide, and mitotane.
  • Seizure medicine—carbamazepine, oxcarbazepine, phenytoin, primidone.
  • Steroid medicine—dexamethasone, prednisone.

Inform your doctor if you have ever suffered from:

  • Kidney or liver disease.
  • Any other malignancies.
  • A blood clot or stroke.
  • A heart attack or other heart condition.
  • If you're suffering from an infection.
  • If you suffer from diarrhea (or loose stools), nausea, vomiting, or diarrhea.
  • If you smoke or were a smoker.
  • If you're experiencing bleeding, suffered from extreme bleeding, or have plans to undergo surgical intervention.

It is unclear whether pacritinib can cause harm to an unborn baby. Notify your doctor if you are pregnant or intend to get pregnant. It might be more difficult for you to become pregnant if you're taking pacritinib. Don't breastfeed during the course of this medication or for at least two weeks after the last dose.

How to take pacritinib?

Follow the directions on the prescription label and read the medication guide or instructions sheets. Make sure you use the medication exactly as prescribed. If you're taking other kinase inhibitors, such as fedratinib or ruxolitinib, it is not advisable to discontinue these medications abruptly prior to starting pacritinib. Follow the instructions of your physician about increasing your dosage. Pacritinib is typically taken twice a day, with and without meals. Suck the capsule whole, and don't crush or chew on it, break it, or even open it. You'll need blood tests prior to beginning pacritinib treatment and throughout the course of treatment. Pacritinib treatment may be delayed or discontinued permanently in the event that you experience specific side effects. Maintain at room temperature, away from heat, moisture, and light.

Details on dosage

Usual Adult Dose for Myelofibrosis:

200 mg orally, 2 times per day
Treatment of patients with high-risk or intermediate either primary or second (post-post polycythemia vera or post-essential blood clots) myelofibrosis (MF) that have a platelet count of less than 50x 10(9)/L (50 times 10(9)/L)

What happens if I miss a dose?

You should take the medication as soon as possible. However, avoid your missed dose if you are nearing the time to take the next dose. Do not take two doses at the same time.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow your doctor's advice regarding food, drinks, or any activity.

Interaction with other drugs

It is sometimes not safe to take certain medications in conjunction with other medications. Certain medications can alter your blood levels and the other drugs that you are taking, which can create side effects or render the medications less effective. Other medications can affect pacritinib's effect, including prescription and over-the-counter medicines, vitamins, and herbal products. Discuss with your doctor all other medicines you take.