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Name of the generic: selinexor [SEL-i-NEX or
Brand names: Xpovio 100 mg once-weekly, Xpovio 40 mg once-weekly, Xpovio 40 mg twice-weekly, Xpovio 60 mg once-weekly, Xpovio 60 mg twice-weekly,…
Dosage format: (20 mg, 40 mg, 50 mg, 60 mg)oral tablet
The class of drug: miscellaneous antineoplastics

How is Selinexor?

Selinexor is used along with Bortezomib or dexamethasone to treat multiple myeloma in adults.Selinexor is also utilized for adults to treat certain kinds of lymphoma with a large number of B-cells.Selinexor is prescribed after other medicines have failed or been discontinued.

In clinical trials, certain individuals responded to selinexor, but more research is required.Selinexor can be used for other purposes that are not mentioned in this medication guide.

Side effects is Selinexor

See a doctor immediately. If you are experiencing symptoms that are warning signs of an allergic response, such as difficulty breathing, hives, or swelling of your lips, face, and throat,Selinexor could cause fatal or serious adverse consequences. Some adverse reactions may not be noticed until after you have taken this medication for a number of days or even weeks.

Selinexor can cause severe adverse consequences. Contact your physician immediately if you suffer from:

  • Blurred vision blurred vision, pain, or seeing a lot of light sources;
  • Severe ongoing nausea, vomiting, or diarrhea;
  • Lack of appetite that prevents you from eating and results in the loss of weight
  • Dizziness, confusion, fainting, or changes in mental state
  • Signs that are indicative of sepsis signs of sepsis The symptoms of sepsis include fever and chills. Intense fatigue, rapid heartbeats, fast breathing, and feeling sick;
  • Symptoms of fevers Signs of infection include chills, fever, coughs with mucus, throat and mouth ulcers, feeling tired and tingling, or a painful blistering skin rash on the other or both sides of your body.
  • Low sodium levels low sodium level, headache low sodium level, slurred speech, extreme weakness, vomiting, loss of coordination, and feeling unstable

The treatment you receive might be delayed or stopped if you experience specific adverse effects.

Common selinexor side effects could include:

  • Blurred vision, double vision sensitivity to light or glare
  • Tiredness;
  • Numbness, tingling, and burning sensations in your feet or hands
  • Anemia: bleeding, bruising, or swelling;
  • Higher blood sugar levels
  • Infection, fever, cold, or flu symptoms;
  • Variations in mineral and sodium levels;
  • An abnormal kidney or liver function test;
  • Nausea, nausea, vomiting, loss of appetite
  • Diarrhea, constipation;
  • Weight loss;
  • Breath shortness.

This isn't a complete list of all possible side adverse effects. Other side effects could be present. Contact your doctor to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


You could contract infections more often, including deadly or life-threatening illnesses. Call your doctor when you experience fever or chills, flu symptoms such as coughs, mouth ulcers, or trouble breathing.

Selinexor may also result in lower blood platelet counts. Inform your doctor immediately in the event of unusual bruising or bleeding.

Prior to use this drug

Inform your doctor if you were ever diagnosed with:

  • Cataracts;
  • Bleeding issues
  • An active or recent infection.

It's possible to require a pregnancy test that is negative prior to beginning this treatment.Men and women using selinexor need to use birth control to stop the pregnancy. Selinexor can harm an unborn child if the mother or father are using the medication.

Continue using the birth control until at least one week after the last dose. Inform your doctor immediately in the event of a pregnancy occurring when both the mother and father are taking selinexor.

This medication can affect fertility (the ability to have children) for both men and women. But it is crucial to use birth control in order to stop pregnancy, as selinexor could cause harm to a baby who is not born.Don't breastfeed during the course of this medication for at least one week following the last dose.It is not permitted to be used by anyone who is under the age of 18.

How to take Selinexor?

Your doctor will run tests to determine if selinexor is the best treatment for your needs.Follow all the instructions on the prescription label and review all medication guides and instructions sheets. Your doctor might alter your dosage. Make sure you take the medication precisely as directed.

Selinexor is generally taken on certain days, usually at least once or twice a week. Follow the instructions of your physician attentively regarding when and how to take selinexor when you are taking dexamethasone or bortezomib.Your doctor will decide the duration of treatment with dexamethasone and selinexor.

Selinexor is taken with a full bottle of drinking water. Take the tablet in one swallow and make sure you don't crush, chew, or break it.If you experience vomiting shortly after taking selinexor, don't take a dose again. The next dose should be taken in the same way as you were scheduled.

You might also be prescribed other medicines to prevent nausea, vomiting, infections, or nausea. Take these medications for the duration your doctor prescribes.There is a chance that you will contract infections more often, or even fatal infections. You'll require frequent medical tests. It is possible to require a transfusion in case the platelets in your blood become too low.

The levels of sodium in your blood must be evaluated. If your levels are way too low, your physician might recommend salt pills or intravenous (IV) fluids to help keep your body from becoming dehydrated.Get plenty of fluids to avoid dehydration. Also, consume enough calories to avoid losing weight.Selinexor may affect your appetite and ability to consume food. The patient will be weighed prior to or during your treatment to ensure that you do not lose weight when taking selinexor.

Place it in a cool, dry place far from heat and moisture. Store each tablet within the package until you are in a position to start taking your medication.

Details on dosage

Usual Adult Dose for Multiple Myeloma:

100 mg taken orally, once a week on the first day of every week, until progression of the disease or unacceptable toxicity is encountered with Bortezomib 1.3 mg/m2 subcutaneously every week on the first day of each week for 4 weeks, followed by one week off; dexamethasone, 20 mg orally, twice a week on days 1 and 2 each week.
80 mg taken orally on days 1 and 3 each week, until the progression of disease or unacceptable toxicity is encountered with dexamethasone; 20 mg orally in the doses of selinexor on days 1 and 3 of every week.
For more information on the administration of bortezomib or dexamethasone, consult its prescription information.
It is recommended to consider IV hydration for those at high risk of being dehydrated.
Prophylactic treatment for concomitant use by a 5-HT3 antagonist and/or other anti-nausea medications before and during treatment
In conjunction with bortezomib and dexamethasone to treat patients suffering from multiple myeloma who have had at least one prior treatment
In combination with dexamethasone, patients suffering from relapsed or refractory multiple myeloma who have had at least four previous therapies and who are resistant to at least two inhibitors for proteasomes, at least two immunomodulatory agents, and anti-CD38 monoclonal antibodies

Usual Adult Dose for Lymphoma:

60 mg orally every day 1, 3, and 4 of every week, until the progression of disease or toxicity is unacceptable.
Consider IV hydration for patients who are at risk of being dehydrated.
Provide prophylactic concurrent treatment with a 5-HT3 antagonist or other anti-nausea medications before and during treatment.
Use: To treat relapsed or refractory massive B-cell lymphoma (DLBCL) that is not specifically defined, such as DLBCL that results from follicular lymphoma, in the absence of at least two treatments with systemic therapy.

What happens if I miss the dose?

Don't miss the dose you missed, and take your next dose at your regular time. Don't take two doses at once.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Avoid driving and other hazardous activities until you understand the effects of selinexor on your body. Your reaction could be affected.

Interaction with other drugs

Other medications may interact with selinexor, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your physician about any other medicines you take.



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