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What are Emtricitabine, Rilpivirine, and Tenofovir?
Emtricitabine, rilpivirine, and tenofovir are combination medications that are used to treat the human immunodeficiency virus (HIV), which is the virus that causes acquired immunodeficiency syndrome (AIDS). Emtricitabine and rilpivirine are the three main ingredients. Tenofovir does not serve as a cure for HIV or AIDS.Emtricitabine and rilpivirine, as well as tenofovir, are for children and adults who are 12 years old and weigh at least 77 lbs (35 kg).Emtricitabine, rilpivirine, and tenofovir can also be utilized for reasons not covered in this medication guide.
Side Effects of Emtricitabine, Rilpivirine, and Tenofovir
Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as hives, difficulty breathing, and swelling of your lips, face, and tongue,Get medical attention in the event of a serious reaction to a drug that affects various parts of your body. Symptoms may include an itch that blisters, a skin rash, fever and mouth sores, the redness of your eyes, swelling of the glands, difficulties swallowing or breathing, upper stomach pain on the right side, uncommon bruising, and dark urine.Emtricitabine, rilpivirine, and tenofovir could result in serious adverse reactions. Consult your doctor immediately. If you suffer from:
- Depression or mood swings, anxiety, feelings of agitation and suicidal thoughts or actions are all symptoms that require medical intervention.
- Kidney issues: little or no urine output, swelling of your ankles and feet, and feeling fatigued or sluggish;
- Acidosis, lactic--unusual muscle pain, and breathing problems, stomach pain, vomiting or irregular heartbeat, dizziness, and the sensation of being cold or feeling extremely tired or weak.
- Issues with the liver, such as stomach discomfort, nausea, lack of appetite, black stools, dark urine, and jaundice (yellowing of the eyes or skin).
This medicine can affect your immune system and could cause negative side effects (even months or weeks after taking it). Inform your doctor when you experience:
- Symptoms of a new infection: fever, night sweats, swollen glands, cold sores, cough, and wheezing. Diarrhea, weight loss
- Difficulties swallowing or speaking issues with balance or eye movement, weakness, or a prickly sensation; or
- Swelling in your throat or neck (enlarged thyroid), menstrual cycles, impotence
Common adverse effects of emtricitabine, rilpivirine, and tenofovir might be:
- Headache, dizziness, tiredness;
- Depression, insomnia, odd dreams, depressed mood;
- The rash
- Nausea, diarrhea.
This isn't an exhaustive list of all the side effects. Other side effects could occur. Consult your physician for advice regarding medical effects.Report any adverse reactions directly to the FDA by calling their hotline at 1-800-FDA-1088.
Similar/related drugs
Biktarvy, Descovy, Truvada, Tenofovir, Atripla, Complera, and Stribild
Warnings
Discuss with your doctor the medicines you are currently taking as well as any new medications you decide to start or stop taking. A variety of drugs interact, and certain medications should not be combined.If you've ever suffered from hepatitis B, it could become active or worsen when you stop taking this medication. You could require regular liver function tests over time.
Before you take this drug
It is not recommended to consume Complera as well as Odefsey if you have an allergy to rilpivirine, emtricitabine, or tenofovir.The medicine is not recommended for use by anyone who is younger than 12 years old or who weighs under 77 pounds (35 kg).
There are many additional medications that could reduce the effectiveness of Complera as well as make Odefsey less effective and should not be taken simultaneously:
- Dexamethasone (more than one dose);
- John's wort;
- Tuberculosis medication: rifampin, rifapentine;
- Seizure medicine: carbamazepine, oxcarbazepine, phenobarbital, phenytoin, or
- Stomach acid reducers—dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole.
Speak to your doctor if you were ever diagnosed with:
- Kidney disease;
- The liver condition (including hepatitis b and c);
- Depression, suicidal thoughts or suicidal ideas, and
- Bone-related issues.
The doctor will conduct blood tests to ensure that you don't have Hepatitis B.Inform your doctor if you are expecting a baby, and take the correct medications to manage your infection. HIV could be transmitted to your child if the virus is not managed during pregnancy. Your name might be recorded on a registry that tracks the effects of antiviral medication on your baby.Women who have HIV or AIDS are not allowed to give birth to a baby. Even if your child is born with no HIV or AIDS, the virus could be transmitted to your baby through breast milk.
How to take Emtricitabine, Rilpivirine, and Tenofovir?
Follow the directions on the prescription label and read the medication guide or instructions sheets. Follow the medication exactly as prescribed.Make sure to take this medication along with food.Complera and Odefsey dosages are based on the weight of children. Your child's dosage requirements could be altered if the child loses or gains weight.You'll require frequent medical tests. Your bone density might require testing.If you've had any experience with hepatitis B, the virus could be active or worsen within the following months after you stop taking the medicine. You could require regular liver function tests throughout treatment and for a few months following the last dose.Don't alter your dosage or schedule of dosing without consulting your physician. Everyone suffering from HIV must remain under the supervision of a physician.Place this medicine in the original bottle at room temperature, away from heat and moisture.
Details on dosage
Usual Adult Dose for HIV Infection:
1 tablet taken orally every day
Comments:
Pregnant women who were taking this medication prior to becoming pregnant and are virologically unaffected (HIV-1 levels less than 50 copies/mL) can continue taking 1 tablet, orally, once a day. As lower levels of rilpivirine exposure were observed during pregnancy, viral levels must be checked regularly.
Use: As a complete regimen for the treatment of HIV-1 infection, as initial therapy in patients with no antiretroviral treatment history with HIV-1 RNA up to 100,000 copies/mL, or to replace a stable antiretroviral regimen in patients who are virologically suppressed (HIV-1 RNA less than 50 copies/mL) for at least 6 months with no history of treatment failure and noThere are known substitutions associated with resistance to individual components.
Usual Pediatric Dose for HIV Infection:
At least 35 kg, one tablet, orally every day
Comments:
Girls who were taking the drug prior to pregnancy and are virologically unaffected (HIV-1 levels less than 50 copies per milliliter) can continue taking one tablet, orally, once a day. As lower rilpivirine exposures have been observed during pregnancy, the viral load is to be checked regularly.
Uses: As part of a complete regimen for treating HIV-1 infection, for initial therapy with HIV-1 RNA up to 100,000 copies/mL and no antiretroviral treatment history prior to starting this medication or as maintenance therapy in individuals without previous antiretroviral experience; or to treat persistent infection. 100,000 copies/mL, or to replace a stable antiretroviral regimen in patients who are virologically suppressed (HIV-1 RNA less than 50 copies/mL) for at least 6 months with no history of treatment failure and no known substitutions associated with resistance to the individual components.
What happens if I miss the dose?
Consume the medication by eating a meal as quickly as you can. However, avoid your missed dose in case you exceed 12 hours behind on the dose. Do not take both doses at the same time.Refill your prescription prior to the time that you are out of medication completely.
What happens if I overdose?
For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.
What should be avoided?
The use of this medication will not hinder the spread of your disease. Be sure to not engage in unprotected sexual sex or share toothbrushes, razors, or razors. Discuss with your physician safe methods to avoid HIV transmission through sex. Sharing needles for medicine or drugs is not a good idea, even for healthy people.
Interaction with other drug
Certain medicines may make Complera or Odefsey less effective when used in conjunction. If you are taking any of these medicines, you should take them with your HIV treatment.
- An antacid: take the medication at least two hours prior to or after having taken Complera or Odefsey.
- Acid reducer for the stomach (such as Tagamet, Pepcid, or Zantac)—take it at least 12 hours prior to or 4 hours following having taken Complera as well as Odefsey.
Complera or odefsey may damage your kidneys or trigger an acute heart condition. Your risk is higher if you take various other medications for infections or asthma, heart issues, high blood pressure, mental illness, depression, cancer, malaria, osteoporosis, the rejection of organs for transplant, intestinal diseases, or arthritis pain (including Advil, Motrin, and Aleve).Certain drugs may affect Complera or Odefsey. Some drugs are not recommended to be taken simultaneously. Discuss with your doctor your current medications and any medication you begin or stop taking. This includes prescription and over-the-counter medicine, vitamins, and herbal supplements. The interactions between these products are not mentioned here.