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Generic name: emapalumab [EM-a PAL-ue-mab “EM-a-PAL”

Name of the brand: Gamifant
Formulation for dose: intravenous solution (5 mg/mL)
Drug class: selective immunosuppressants

What is Emapalumab?

Emapalumab can be used in conjunction with the medication dexamethasone to treat hemophagocytic lymphohistiocytosis (HLH). This is an uncommon condition that can be passed down through the generations. HLH can cause immunity to fight healthy cells. This can cause severe or even life-threatening consequences for your spleen and liver. Emapalumab is recommended for the adult population as well as children as young as newborns.Imalumab is administered in the aftermath of other treatments that have failed or not been effective.Emapalumab is also employed for other purposes that are not covered in this medication guide.

Side effects of Emapalumab

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as difficulty breathing, hives, or swelling of your lips, face, or tongue,Certain side effects can occur during the course of the injection. Inform your doctor when you are feeling ill, chills, sweaty and itchy, feel lightheaded and nauseated, or if you experience chest discomfort, shortness of breath, or the appearance of a skin eruption or swelling.

It is possible to contract infections more often, including severe or fatal infections. Call your doctor immediately if you show indications of an infection, like:

  • Fever, chills, night sweats, chills
  • Loss of appetite appetite loss, weight gain;
  • Getting very tired;
  • The appearance of redness, warmth, or sores that hurt over your body;
  • Cough, trouble breathing
  • Ulcers in the throat and mouth;
  • Cough that has bloody mucus
  • Any other new or deteriorating indications of any other signs

Common negative side effects of emapalumab can include:

  • Fever
  • An increase in blood pressure.

This is not a comprehensive list of possible side effects, and other side effects could occur. Consult a physician if you are nursing or pregnant.You can report any side effects to the FDA at 1-800-FDA-1088.


Emapalumab can affect the immune system. It is possible to contract infections more often, including deadly or life-threatening illnesses. Call your doctor when you experience an illness that causes chills, fever, and evening sweats, or skin rashes and cough, breathing problems, or a cough that is bloody mucus.

Before you take this drug

Inform your doctor if you have ever suffered from tuberculosis or if someone in your family has tuberculosis. Inform your doctor if you've recently been on a trip. Tuberculosis, as well as some fungal illnesses, are more prevalent in specific regions of the world. You could have come in contact with them during your travels.

Speak to your doctor if you have ever suffered from:

  • A negative tuberculosis (TB) skin test;
  • Any kind or type of disease (active or recent);
  • Histoplasmosis (a fungal infection);
  • Herpes zoster (shingles);
  • If you're scheduled, get a vaccination.

Consult your physician if you are nursing or pregnant.

How to take Emapalumab?

Before starting treatment with omalizumab, your doctor might conduct tests to ensure that you don't have tuberculosis or any other infections.Emapalumab is administered in the form of an injection into a vein, typically every 3 to 4 days. The healthcare professional will give the injection.Emapalumab is administered slowly. The infusion could take up to an hour to complete.Emapalumab can affect the immune system. You could contract infections more frequently, and even severe or fatal infections. Blood tests are required to help your doctor determine the length of time you should be treated with this medication.There are other medicines to prevent serious infections. Continue to take these medications for the duration your doctor prescribes.

What happens if I miss the dose?

Contact your doctor for advice. If you do not make an appointment for an emapalumab injection,

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Don't receive any "live" vaccine while using emapalumab for at least four weeks following the last dose. Live vaccinations can include measles, rubella, and mumps (MMR), as well as polio, the typhoid virus, rotavirus, yellow fever, varicella (chickenpox), zoster (shingles), and the nasal influenza (influenza) influenza vaccine.

Interaction with other drug

Other medications can affect emapalumab, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your physician about the medicines you are currently taking and any medication you begin or stop taking.