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Name of the generic: ramucirumab It is RA-mue, SIR-ue-mab.
Drug class: VEGF/VEGFR inhibitors

What is Cyramza?

Cyramza is a medicine for cancer that blocks the spread and growth of cancerous cells in the body. Cyramza will treat stomach cancer, colorectal cancer, and non-small cell lung cancer, which is spreading to different regions of the body. It also treats hepatocellular cancer. Ramucirumab can be administered by itself or in conjunction with other cancer medications. Cyramza is generally prescribed after the other cancer treatments have not worked.


Cyramza increases the chance of having serious bleeding. Take this medicine off and contact your doctor at the earliest opportunity if you are experiencing extreme stomach discomfort, bleeding, bloody stools, coughing up blood, or any other unusual or severe bleeding.

Prior to use this drug

Cyramza should not be used in the event that you are allergic to ramucirumab or you've had any of the following:

  • Uncontrolled excessive blood pressure

To be sure, Cyramza is not harmful for you. Talk to your doctor if you suffer from:

  • High blood pressure
  • A thyroid disorder
  • An incision that is not healed from an operation that was recently completed.

This medication can cause harm to the unborn baby. Consult your physician if you are expecting or planning for pregnancy while taking this medication. Ramucirumab could impact fertility (your capacity to have babies).

Utilize birth controls to stop pregnancy while receiving Cyramza and for a minimum of 3 months after treatment has ended. It is not recommended to breastfeed while taking ramucirumab.

How to take Cyramza?

Cyramza is a drug that can be administered as an injection into a vein via an IV. Your healthcare provider will provide the infusion. It is possible to receive medication to reduce certain adverse reactions while you take it. Cyramza can be administered once every two weeks. It can also be administered as a 21-day treatment, and you might only have to take the medication on the first days of every cycle. Follow the dosing guidelines of your doctor with care. When you are taking Cyramza, you might require regular urine or blood tests. Your blood pressure needs to be monitored regularly. If you require surgery, inform your doctor ahead of time that you're using Cyramza. It may be necessary to stop taking the medication for a brief period of time.

What happens if I miss the dose?

Consult your physician for the appropriate treatment in the event that you don't make an appointment to receive the Cyramza injection.

What happens if I overdose?

Because the medicine is prescribed by a medical expert in a medical environment, the risk of overdose is less likely to occur.

What should be avoided?

Follow your doctor's advice regarding any restrictions on your food, drink, or activities.

Side effects of Cyramza

Take immediate medical attention. Get medical attention immediately if you show symptoms that you are experiencing an allergic reaction to Cyramza, such as difficulty breathing, hives, or swelling of your lips, face, and tongue.

Certain side effects can occur after the injection. Inform your doctor immediately when you feel lightheaded, chill, sweaty, have chest pain, tightness in your chest, back pain, difficulty breathing, numbness, or sensations of tingling.

Cyramza could increase the chance of having serious bleeding. Contact your doctor immediately. If you are suffering from:

  • Symptoms of stomach bleeding, extreme stomach pain, bloody or tarry stool, coughing blood, or vomit that appears to be coffee grounds
  • Any injury that is not able to heal;
  • Headache, confusion, change in mental status, vision loss, seizure (convulsions);
  • Persistent or severe nausea, vomiting, diarrhea, or nausea;
  • Rapid weight loss, particularly around your midsection and face;
  • Lower white blood cell count, fever, oral sores, and skin sores cough, sore throat, difficulty breathing;
  • Kidney issues eye puffiness, swelling in your feet or ankles, weight gain, and the appearance of your urine as foamy;
  • Signs of a blood clot The symptoms of a blood clot include sudden weakness or numbness (especially in one part of your body). An intense headache that is sudden or slurred speech, issues with balance or vision,
  • Heart attack symptoms include chest pressure or pain radiating into your shoulder or jaw, nausea, and sweating.

Common Cyramza adverse effects could include:

  • Spots of white or red sores and around the area of your mouth gums that are red or swollen, difficulty swallowing or speaking, bad breath, dry mouth, and a change in taste
  • Fatigue or feeling weak;
  • Loss of appetite, diarrhea;
  • Nosebleed;
  • Low white blood cell count; or

This is not a comprehensive list of possible side effects, and others could happen. Contact your doctor to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Other medications may interfere with ramucirumab. This includes prescription and non-prescription medicines as weacll as vitamins and herbal products. Inform your health professionals about the medicines you take currently and all medicines you stop or start taking.