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Esomeprazole (injection)

Generic name: esomeprazole (injection) [EE-soe-MEP-ra-zole]
Trade name: NEXIUM I.V.
Form of dosage: intravenous powder for injection (40 mg).
Drug class: proton pump inhibitors

What is Esomeprazole (injection)?

Esomeprazole is used for treating symptoms associated with gastroesophageal reflux disease (GERD) and conditions that involve excessive stomach acids, such as Zollinger-Ellis syndrome. Esomeprazole can also be used to treat erosive esophagitis, which is damage to the esophagus due to stomach acid.Esomeprazole is used as an injection to reduce the risk that an ulcer will bleed again following a procedure.This medication guide does not list all possible uses of esomeprazole.

Side effects of Esomeprazole

If you experience any of the following symptoms of an allergy: difficulty breathing, hives, swelling in your lips, face, throat, or tongue

Esomeprazole can cause severe side effects. If you experience:

  • Severe abdominal pain, diarrhea, watery or bleeding;
  • Seizure (convulsions);
  • Kidney problems: fever; rash; nausea; joint discomfort. Urinating less often than normal causes blood in the urine.
  • Low magnesium—dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, coughing or choking feeling;
  • New or worsening symptoms are joint pain and an inflammatory rash that is worse in the sun.

Long-term use of esomeprazole may lead to stomach polyps known as fundic glands. Speak to your doctor regarding this potential risk.

Some of the common side effects associated with esomeprazole include:

  • Headache, dizziness;
  • Diarrhea, constipation;
  • Nausea, stomach pain, gas;
    dry mouth
  • Itching
  • Redness, itching, or swelling around the iv

There may be other side effects. For medical advice on side effects, call your doctor.Report adverse reactions by calling the FDA at 1-800-FDA-1088.


Esomeprazole may cause kidney damage. If you notice that you are not urinating as much or have any blood in your urine, tell your doctor.Diarrhea can be an indication of a new virus. If you experience diarrhea with blood or water, call your doctor.Esomeprazole can cause new symptoms or worsen existing lupus. You should tell your doctor about joint pain or a rash that gets worse in the sun.It is possible that you are more likely to break a bone if you use esomeprazole for a long time or more often than once a day.

Before you take this drug

Acid reflux may mimic the early signs of a heart attack. If you experience chest pain that spreads from your neck to the shoulder or jaw and makes you anxious or dizzy, you should seek emergency medical attention.

This medicine should be avoided if you:

  • You also take medicines that contain rilpivirine.
  • You had severe allergies, breathing issues, or kidney problems after you took esomeprazole before.
  • You are allergic to esomeprazole (or similar drugs such as Nexium, omeprazole, and Prevacid).

Many drugs interact with each other and can cause serious side effects. Certain drugs shouldn't be taken with esomeprazole. If you are also taking

  • Clopidogrel;
  • Methotrexate (at high doses);
  • Rifampin;
  • St.
  • Medicines that contain rilpivirine, such as complera (also known as edurant), juluca, or odefsey

If you've ever:

  • Severe liver disease
  • Lupus;
  • Osteoporosis, or low bone mineral densities (osteopenia).
  • Low levels of magnesium are harmful to your health.

Discuss with your doctor how to maintain healthy bones.Inform your doctor of any pregnancy or nursing.

How to take Esomeprazole?

Read all the instructions or guides that come with your medication and follow all the directions. Follow the directions on your prescription label.Esomeprazole can be injected only when you cannot take it by mouth.Esomeprazole is injected into the vein. Your healthcare provider may give you your first dose and teach you to use it properly.Esomeprazole can be given up to 10 times a day to treat GERD, or erosive esophagitis.Esomeprazole can be administered continuously for up to 72 hours in order to prevent bleeding after an endoscopy. Then, you may be told to take an acid-reducing medicine orally.In some cases, you may have to add a liquid diluting agent (esomeprazole) to an IV bag. If you are using the injections yourself, make sure that you know how to mix and store them.

Follow all instructions for use that come with your medication. If you do not understand the instructions, don't use them. If you still have any questions, ask your pharmacist or doctor.Only prepare your injection when you're ready to administer it. If the color of your medicine changes or if it contains particles, do not use it. For new medication, call your pharmacist.This medicine comes in a single-use bottle (vial). After one use, throw it out, even if the medicine is still inside.Even if you feel better quickly, continue to take this medication for the prescribed time. You can use it as needed if you're using esomeprazole.If your symptoms don't improve or worsen while taking the medicine, call your doctor.Tell your doctor that you are taking esomeprazole. Inform any doctors who treat you that you use esomeprazole.Keep away from heat, moisture, and light.

Use the esomeprazole injectable mixture as quickly as possible. Store it at room temperature. The mix will only be effective for 6–12 hours, depending on what type of liquid diluteant is used.Only use a needle or syringe once, and place it in the "sharps container" to prevent punctures. Be sure to follow local or state laws on how you should dispose of the container. Keep the device out of reach from pets and children.

What happens if I miss the dose?

If you forget to take a dosage, call your doctor.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

Avoid this

Esomeprazole may cause diarrhea. This could be an indication of a fresh infection. Call your doctor if you experience diarrhea that's watery or bleeding.

Interaction with other drug

Inform your doctor of all the medications you are taking. Esomeprazole can be affected by many drugs, including:

  • Cilostazol;
  • Clopidogrel;
  • Diazepam;
  • Digoxin;
  • Erlotinib;
  • Iron-containing drugs (ferrous fumarate, ironous gluconate, ferrous sulfate, and others);
  • Methotrexate;
  • Mycophenolate mofetil;
  • Rifampin;
  • John's wort;
  • Tacrolimus;
  • Warfarin (coumadin, jantoven);
  • Antifungal medication—ketoconazole, voriconazole,
  • Hiv/aids medication: atazanavir, nelfinavir, and saquinavir.

The list of drugs that can interact with esomeprazole is not exhaustive. These include prescription, over-the-counter, and herbal medicines. This list does not include all possible drug interactions.