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Generic Name: Factor IX complex [FAK-tor-NINE-KOM-plex].
Names of Brands: Profilnine, Bebulin, Bebulin VH, Profilnine SD.

What is Bebulin?

Factor IX (nine) is a naturally occurring protein in the blood that helps the blood form clots. Insufficient factors for clotting can result in uncontrolled bleeding because the blood does not effectively clot. Bebulin is a mixture of four different clotting factors as well as other proteins. The medication is used to temporarily increase the concentrations of these factors within the blood, which aids in the process of clotting. It is prescribed to manage or stop bleeding in patients suffering from factor IX deficiencies (hemophilia B). It can also be used to manage bleeding from surgical or dental procedures in patients who suffer from hemophilia B.

Side effects of Bebulin

Take immediate medical care. If you notice symptoms that are warning signs of the presence of an allergy, such as an allergic reaction that causes hives, an itch, or a rash; rapid heartbeats; tension in your chest; wheezing; difficulty breathing; swelling of your lips, face, or tongue,

Bebulin can cause severe adverse reactions. Take a break from Bebulin and contact your doctor immediately if you experience:

  • Being sweaty and feeling tired.
  • A feeling of lightheadedness, as if you're about to pass out.
  • Easily bruising; more bleeding episodes.
  • Bleeding from a cut or the site where there was an injection of medicine.
  • Indications for a blood clot within the lung, such as chest pain, a rapid cough, wheezing and rapid breathing, and coughing up blood.
  • Indications that a blood clot has formed on your leg: swelling, pain, or warmth in both legs.

Common adverse reactions to bebulin include:

  • Headache.
  • Flushing (warmth of redness or tingling feeling).
  • Nausea, vomiting.
  • Fever, chills.
  • Energy deficiency.

This isn't a comprehensive list of all the possible side effects. Other side effects could occur. Consult your physician to seek medical advice on the effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Follow all the instructions on the label of your medication and on the label of your package. Be sure to inform your healthcare professionals about your medical ailments, allergies, and any medications you take.

Before you take this drug.

Your doctor will run blood tests to confirm that you have a factor IX deficiency, which is the cause of your particular bleeding condition. Bebulin is not effective for treating deficiencies in other factors that cause blood clotting.

The doctor might ask you to have a hepatitis vaccination prior to beginning to take Bebulin. To be sure Bebulin is suitable for you, inform your physician if you:

  • If you suffer from liver
  • If you're allergic to latex.
  • You have had surgery recently.
  • You are scheduled to undergo surgery.

It is unclear if Bebulin could harm a stillborn baby. Inform your doctor if you are expecting or planning to be pregnant. It is unclear if the factor IX compound is present in breast milk or whether it can affect a nursing baby. Consult your physician if you are breastfeeding.

Bebulin is not a drug that has been approved to be used by anyone younger than 18 years old. Bebulin is made of human plasma (part of the blood), which could be contaminated with infections and viruses. Plasma donated to the clinic is analyzed and treated to lower the chance of it being contaminated by infectious agents; however, there is a slight chance of it transmitting diseases. Discuss with your physician the dangers and benefits of this treatment.

How to take Bebulin?

Follow the directions on the prescription label. Don't use this medication in smaller or larger quantities or for a longer time than prescribed. It is administered into veins via an IV. It is possible to be taught how to inject an IV at home. Do not inject yourself with this medication if you do not know how to administer the injection correctly and eliminate IV tubing, needles, and other equipment that is used. Always confirm the strength of the drug in the package to make certain that you are using the correct dosage. Clean your hands prior to preparing and administering your injection.

Factor IX needs to be mixed with the aid of a liquid (diluent) prior to use. The medicine and the diluent must be taken out of the fridge and let them reach room temperature prior to mixing the dosage. Don't heat the medication or the diluent. If you're using infusions at home, make certain you know how to combine and keep the medication. After mixing it, gently swirl the mix and let the mixture completely dissolve. Make use of the medicine as soon as you are able after mixing. Mixing medicine can be stored at room temperature, but you should use it within three hours. Do not place mixed medicines in your refrigerator. Preparing your dose using a syringe only after you're ready to inject yourself Be sure not to inject the medication if it has changed color or appears cloudy. Consult your pharmacist about the latest medication.

One dose of factor IX could be sufficient to prevent minor bleeding. If you require a subsequent dose, be sure to wait at least 24 hours before taking the medication again. Be sure to check your pulse before and during the injection. If you notice a change in your pulse, reduce your injection or stop it until your pulse is back to normal. Every single-use container (bottle) that contains this medication is only for one use. Toss it away after just one usage, even if there's still a little remaining medicine in it after you have injected your dose. Make use of an empty needle and syringe only once. Be sure to follow any local or state regulations regarding the disposal of used needles and syringes. Make use of puncture-proof "sharps" disposal containers (ask your pharmacist for one and what to do with them). Keep the container away from pets and kids. Wear a medical alert tag or have an ID card showing you suffer from hemophilia. Any doctor who cares for you must know that you suffer from a blood-clotting or bleeding disorder.

If you are in need of any kind of dental surgery or procedure, be sure to inform the dentist or surgeon prior to the time of surgery that you suffer from hemophilia. Your body could produce antibodies, or inhibitors," to bebulin. If your body produces antibodies or "inhibitors" to the clotting factor, the treatment will be less efficient in stopping bleeding episodes. Consult your doctor if you think this medicine may be less effective in reducing the bleeding. When you are taking Bebulin, it is possible that you will require regular blood tests.

Storage Bebulin and its dilution are stored in an airtight container in a refrigerator. Don't put it in the freezer. Keep profilenine and its diluting solution in a cool, dry place far from heat and moisture. Dispose of any medication or diluent once the end date printed on the package has passed.

What happens if I miss a dose?

Because bebulin is often used, you might not be following a dosage schedule. If you're on a regular schedule, you should take the dose you missed as soon as you can remember. Avoid any missed doses if you are close to the time of the next scheduled dose. Don't use any extra medication to replace the missed one.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

What should be avoided?

Follow your doctor's advice regarding any limitations on foods, drinks, or activities.

Interaction with other drugs

Discuss with your doctor all other medications you take, including:

This list isn't exhaustive. Other drugs can be incompatible with factor IX, such as prescription and non-prescription medicines, vitamins, and herbal products. There are not all the interactions mentioned in this medication guide.