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Amlodipine and Valsartan

Generic name: amlodipine and valsartan [am-LOE-de-peen-val-SAR-tan]
Name of the brand: “Exforge
Dosage format: oral tablet (10 mg–160 mg) 10 mg-320 mg; 5 mg-160 mg; 5 mg-320 mg)
Class of drug: angiotensin II inhibitors that block calcium channels.

What is Amlodipine and Valsartan?

Amlodipine and Valsartan are mixture medications that are taken in combination with other medications for treating hypertension in adults.A lower blood pressure could reduce your chance of having a stroke or heart attack.Amlodipine and valsartan can be used for reasons that are not covered in this guide.

Side effects of Amlodipine and Valsartan

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that indicate an allergy, such as hives, breathing difficulties, and swelling of your lips, face, and tongue.In rare instances, when you first begin taking valsartan and amlodipine, your chest pain can become more severe or worse. You could also suffer heart attacks. Make sure you seek medical attention in an emergency or consult your physician immediately if you notice any symptoms like chest pressure or pain, expanding to your shoulder or jaw, nausea, or sweating.

Amlodipine and valsartan could result in serious side effects. Contact your doctor immediately. If you suffer from:

  • A feeling of lightheadedness, as if you're passing out;
  • Heart conditions: swelling rapidly, gaining weight, and feeling tired;
  • Kidney issues: swelling, less urination, being exhausted or weak,
  • High blood potassium causes nausea and weakness. It can also cause tingling sensations, chest discomfort, irregular heartbeats, and decreased movement.

Common side effects are:

  • Swelling of your feet or hands;
  • Spinning sensation, dizziness,
  • Symptoms of the cold, like nasal stuffiness, sneezing, and a sore throat.

This isn't a complete list of possible side effects, and other effects may also be present. Contact your physician for advice regarding medical effects. If you have any concerns, report the reaction to FDA by calling 1-800-FDA-1088.


Do not take it when you are expecting. Stop taking this medication and inform your doctor as soon as possible when you find yourself pregnant.Consult your doctor about medicines you use in addition to the ones listed above. Certain drugs shouldn't be taken with amlodipine or valsartan.

Prior to use this drug

It is recommended not to use amlodipine or valsartan if you are allergic.If you suffer from diabetes, be sure to avoid taking amlodipine or valsartan with any medication containing an ingredient called aliskiren (a blood pressure medication).

Contact your doctor if were ever afflicted by:

  • Heart issues and lower blood pressure;
  • A heart attack;
  • An extreme allergic reaction known as angioedema to a different blood pressure medicine
  • Nausea or suffering from an excessive amount or a lot of diarrhoea;
  • Liver disease
  • Kidney disease (or those who are taking dialysis)

There is a possibility that you should be careful about taking amlodipine as well as Valsartan along with aliskiren in the event that you suffer from renal disease.Don't use it if you are expecting. Stop taking the medication and inform your doctor right away if you find yourself pregnant. Amlodipine and valsartan can cause death or injury to the baby's mother when you use the medication in your third or second trimester.Do not breastfeed.

How to take Amlodipine and Valsartan?

Follow the directions on the prescription label and review all medication guides and instructions sheets. The doctor might alter your dosage. Follow the medication exactly as prescribed.Amlodipine and valsartan are usually used once a day.It is possible to take this medicine in combination with or without food.Your blood pressure is likely to be regularly checked, and you could require frequent blood tests. Treatment options could include exercise, diet, lifestyle changes, lifestyle adjustments, and other medicines. Follow the instructions of your physician attentively.Your blood pressure could become too low if you suffer from a prolonged illness. Consult your physician if you have a stomach ache or diarrhoea.Speak to your doctor if you are planning a procedure.Continue to take amlodipine and Valsartan even if you feel good. The high blood pressure is often accompanied by no signs.Place it in a cool, dry place free of heat and moisture.

Details on dosage

Usual Adult Dose for Hypertension:

Initial treatment: amlodipine 5 mg; valsartan 160 mg once daily orally.
Add-on/replacement treatment: Amlodipine 5 to 10 mg; Valsartan 160 to 320 mg, orally at least once per day.
It is possible to increase the dose within 1–2 weeks of treatment.
A patient who has adverse reactions with a dose limit on either component may be redirected to this drug, which has a lower dosage of the component along with other components. If blood pressure is not controlled after 3–4 weeks, it is possible to increase the dose up to a maximum of 10 mg of amlodipine and 320 mg of valsartan daily, orally.

What happens if I miss the dose?

Do not take the medicine for as long as you can. However, do not take your missed dosage if you are close to the time of the next dose. Don't have two doses at one time.

What happens if I overdose?

In case of medical emergencies, get urgent medical attention, or call for assistance at the Poison Help Line at 1-800-222-1222.The symptoms of an overdose could include fast heartbeats and low blood pressure. Other symptoms include warmth or redness in your legs or arms, as well as falling asleep.

What should be avoided?

Don't consume potassium supplements or salt substitutes unless your doctor has advised you to.Do not get up too quickly from lying or seated in a position where you are dizzy. Avoid driving or engaging in hazardous activities until you are aware of the way that amlodipine and valsartan affect your body. Your reactions may be affected.Consuming alcohol while taking this medication may cause unwanted side effects.

Interaction with other drugs

There are times when it's not safe to take certain medications simultaneously. Certain medications can alter your blood levels and the other drugs you take, which could create side effects or render the medications less effective.

Amlodipine and valsartan could cause kidney damage, particularly when you are also taking certain medications for cancer, infections, osteoporosis, organ rejection to transplant, high blood pressure, arthritis, or pain (including Advil, Motrin, and Aleve).

Discuss with your doctor any medications you are taking. A variety of drugs can interact with amlodipine or valsartan, in particular:

  • Cyclosporine;
  • Sildenafil;
  • Rifampin;
  • Ritonavir
  • Medicine for blood pressure or heart, particularly diuretics ('water pill').

The list below isn't exhaustive, and other medications may be affecting valsartan or amlodipine. This includes over-the-counter and prescription medications, vitamins, and herbal supplements. The list of drug interactions isn't comprehensive. These are the ones listed.




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