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Generic name: pancrelipase [pan-kre-LYE-pace]
The brand names are: Creon, Pancreaze, Pertzye, Viokace, Zenpep, etc. Show all 64 brands
Drug class: digestive enzymes

What is Pancrelipase?

Pancrelipase is a mixture comprising three different enzymes (proteins) that include lipase, protease, and amylase. These enzymes are made by the pancreas and play a role in the digestion of proteins, fats, and sugars.

Pancrelipase is a replacement for these enzymes in cases where the body is not able to produce enough of them. Certain medical conditions may cause this deficiency of enzymes, for example, cystic fibrosis, persistent inflammation in the pancreas, or obstruction of the pancreatic ducts.

Pancrelipase can also be utilized after surgery to remove the pancreas.Pancrelipase is also employed for other purposes that are not covered in this medication guide.

Side effects of Pancrelipase

Seek medical attention immediately. If you are experiencing warning signs of an allergic reaction such as asthma, hives, and swelling of your lips, face, and tongue,

Pancrelipase can cause severe adverse effects. Consult your physician right away. If you suffer from:

  • Joint discomfort or swelling
  • Signs of an uncommon but serious digestive disorder, such as symptoms of stomach discomfort, vomiting, constipation, diarrhea, and constipation.

Inform your doctor if your child's growth isn't at a regular rate when taking pancrelipase.

Common side effects of pancrelipase include:

  • Stomach pain, gas, vomiting;
  • Irregular or frequent bowel movements
  • Retinal scratching;
  • Headache, dizziness;
  • Nasal stuffiness, cough, sore throat,
  • Changes in blood sugar levels.

This is not a comprehensive list of possible side effects, and other side effects could occur. Consult your physician to seek medical advice on adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar or related drugs

azithromycin, Zithromax, gentamicin, Creon, tobramycin, Zenpep, and Pancreaze


Consult your physician immediately if you experience symptoms of a rare but serious digestive disorder such as extreme or unusual stomach discomfort, diarrhea, vomiting, bloating, or constipation.

Before you take this drug

Pancrelipase isn't a good choice when you are allergic to pork protein.

Speak to your doctor if you've ever had:

  • Kidney disease;
  • Gout;
  • Diabetes;
  • An obstruction or scarring your intestines
  • Problems swallowing pills
  • lactose intolerance.

Inform your doctor if you are expecting or planning to become pregnant or if you are breastfeeding or planning to do so.

Don't give pancreas to children without medical advice.

How to take Pancreas?

Follow the directions on the prescription label and also read the medication guides or instruction sheets. Follow the medication exactly as prescribed. Don't switch brands of this medication without your physician's guidance.Pancrelipase should be consumed during a meal or a snack.

Be sure to follow the directions carefully when administering this medication to children. Talk to your pharmacist or doctor for any additional questions.Do not chew, crush, or tear a capsule of pancrelipase tablets. Swallow it whole by drinking a full glass of water.Do not put the tablet in the mouth. Pancrelipase can irritate the mouth's interior.

If you can't swallow the capsule completely, take it out and mix the medication with applesauce. Take the mixture in a single swallow without chewing. Don't mix the medication with formula for infants or breast milk.Don't inhale the pancreas capsule or let it touch your skin. It can cause irritation, primarily to your lungs and nasal area.

Pancrelipase can be given in conjunction with a stomach acid decreaser like Nexium, Prevacid, Prilosec, or Protonix. Follow the instructions of your physician about the use of all medications needed for your health condition.Doses are determined by weight.

Follow the storage guidelines provided by pancrelipase. Your pharmacist can give you more details about storage methods for this medication.Consult your physician if you suffer from any serious or chronic pancreas issues.

Details on dosage

oral delayed release capsule (10,000 units; 32,000 units; 42,000 units) 10,500 units 61,500 units to 35,500 units 12,000 units, 38,000 units, and 60,000 units 15,000 units, 47,000 units, 63,000 units; 16,000 units, 57,500 units, 60,500 units16,800 units; 98,400 units; 56,800 units; 23,000 units; 63,000 units; 84,000 units21,000 units, 83,900 units, 54700 units; 2,400 units, 76,000 units, 120,000 units 24,000 units, 86250 units, and 90,750 units250,000 units, 79,000 units, and 105,000 units2600 units, 15,200 units, and 8800 unitsthree thousand units between 10,000 and 14,400 units three thousand units, 9500 units, or 15,000 unitsthree thousand units, 114,000 units, and 180,000 units 37,000 units, 97300 units, and 149,900 units130,000 units, 126,000 units, and 168,000 units4000 units, 14,375 units, and 15,125 units4200 units, 24,600 units, and 14 200 units 5,500 units, 7,000 units, and 24,000 units 19,000 units-19,000 units-30000 units 8000 units, 28,750 units, 30,250 units,... Display all two dosage forms.

What happens If I miss a dose?

Do not miss the dose. Include it in your next meal, snack or meal. Don't take two doses at once.

Refill your prescription prior to the expiration date of your medication.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on your food, drink, or activity.

Interaction with other drugs

Other medications can influence pancreatic enzyme levels, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about any other medicines you take.



Prescription only

Pregnancy & Lactation

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