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Generical name: amivantamab [AM-eeVAN-ti-mab]
The brand name: is Rybrevant.
Dosage format: intravenous solution (vmjw 50 mg/mL)
Classification of drugs: Miscellaneous antineoplastics

What is Amivantamab?

Amivantamab can be used for treating non-small lung cancer that has an unnatural "EGFR" gene, has been able to spread to other areas of your human body (metastatic), or is not removed by the surgical procedure. The doctor will ensure that you have the right tumour type that is suitable for treatment with amivantamab.Amivantamab can be prescribed when other treatments didn't work, did not perform, or were not effective.Amivantamab is also employed for other purposes that are not covered in this guideline.

Side effects of Amivantamab

Seek medical attention immediately. If you are experiencing symptoms that indicate indications of an allergic response (hives and breathing issues, as well as swelling of the throat or on your face) or a severe hypersensitive reaction to the skin (fever and throatsoreness, burnt eyes, irritation, as well as a red or purple eruption with peeling and blisters),Certain side effects can occur during the course of the injection. Contact your physician. If you experience nausea or lightheadedness, feel sluggish, cold, or hyper, or feel chest pain,

Amivantamab may cause serious side effects. Consult your doctor immediately if you experience:

  • Eye redness or pain, itching, eyes that are watery, sensitivity to light
  • Vision change;
  • Dark floating spots that are dark in your field of view (floaters);
  • Skin conditions like acne, itching, or dryness
  • Respiratory issues (may be a symptom of a tumor)--new or worsening cough, fever, or breathlessness.

The treatment for cancer may be delayed or discontinued permanently when you experience certain adverse consequences.

Common side effects of amivantamab can be:

  • A reaction that occurs during injection;
  • Shortness of breath, cough;
  • Being extremely tired;
  • Rash;
  • Disease of a nail's skin
  • The swelling can be found in the body in any area.
  • Nausea, vomiting, constipation;
  • Mouth sores;
  • Joints or muscle discomfort muscles or joints
  • Unusual blood test results.

This is not a comprehensive list of possible side effects, and other side effects could occur. Contact your doctor for advice regarding medical effects. If you have a concern, report it to the FDA by calling 1-800-FDA-1088.


Amivantamab could cause allergic reactions to the skin. Avoid sun exposure while receiving amivantamab for two months following your last dose.

Prior to use this drug

Ask your doctor about it if you've ever experienced lung issues other than cancer.could harm an infant. You may need a pregnancy test in order to be sure that you're not expecting. Utilise birth controls when you are taking amivantamab for at least three months following your last dose. Consult your physician when you fall pregnant.Avoid breastfeeding during the course of this medication and for a minimum of 3 months following your last dose.

How to take Amivantamab?

Amivantamab is injectable into a vein by a physician, typically once every two to four weeks.The injection of amivantamab takes place slowly over many hours.There are other medicines to prevent severe adverse side effects or an allergic reaction. Continue to take these medications for as long as your physician has prescribed them.You might require frequent eye exams.The rash can cause itching and itchiness as well as dry, irritated skin. Use only alcohol-free lotion to treat dry skin.

Details on dosage

Usual Adult Dose for Non-Small Cell Lung Cancer:

Weeks 1 to 4:
less than 80 kg, 1050 mg IV, once every week for four doses
-At minimum, 80 kg, 1400 mg IV, once every week for four doses
From Week 5 onwards:
Less than 80kg: 1050 mg IV once every 2 weeks
Aim for at least 80 kg of 1.400 mg intravenous every two weeks.
The duration of therapy: up until the disease progresses or toxicity is unacceptable.
Infusion Rates for a 1050 mg Dose:
Week 1 (split dose infusion):
Day 1 (350 mg dose):
----- Initial rate: 50 mL/hour
----- Subsequent rate: 75 mL/hour
Day 2 (700 mg dose):
----- Initial rate: 50 mL/hour
----- Subsequent rate: 75 mL/hour
Week 2 (1050 mg dose): 85 mL/hour
Subsequent days (1050 mg dosage) (125 mL/hour)
Infusion Rates for a 1400 mg Dose:
Week 1 (split dose infusion):
Day 1 (350 mg dose):
----- Initial rate: 50 mL/hour
----- Subsequent rate: 75 mL/hour
Day 2 (1050 mg dose):
----- Initial rate: 35 mL/hour
----- Subsequent rate: 50 mL/hour
Week 2 (1400 mg dose): 65 mL/hour
Week 3 (1400 mg dose): 85 mL/hour
Subsequent months (1400 mg daily dose) (125 mL/hour)
The dose should be calculated based on the body's weight at baseline, and dose adjustments are not required for subsequent weight fluctuations.
The initial dose is to be given as a split infusion at the beginning of Week 1 between Day 1 and Day 2.
Prior to the infusion that will be administered during Day 1 (Days 1–2), the premedication needs to be administered to decrease the chance of reactions related to infusions.
An antihistamine and an antipyretic are advised prior to any infusion.
A glucocorticoid is recommended during Week 1 (Days 1–2) doses only. It should be administered when needed for future infusions.
The initial rate of infusion could increase to the next infusion rate after two hours without the risk of an infusion-related reaction.
Use: To treat patients suffering from metastatic or locally advanced non-small-cell lung cancer (NSCLC) with epidermal growth receptor (EGFR) exon 20 insertion variants, as determined by the FDA-approved US test, whose cancer has developed after or following platinum-based chemotherapy.

What happens if I miss the dose?

Contact your doctor for advice in the event that you don't make an appointment to receive the injection of amivantamab.

What happens if I overdose?

In a medical environment, an overdose could be immediately treated.

What should be avoided?

Amivantamab could result in skin rashes. Avoid sun exposure and tanning beds while you are taking treatment, as well as for two months after the last dose. Protect yourself with protective clothes and sunblock (SPF 30 or greater) whenever you go outside.If you are experiencing problems in your eyes, stay away from using contact lenses until symptoms are evaluated by an eye specialist.

Interaction with other drugs

Other drugs can interact with Amivantamab's effects, including prescription and non-prescription medications, vitamins, and herbal products. Discuss with your doctor all the other medications you take.




Prescription only

Pregnancy & Lactation

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