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Amitriptyline and perphenazine

Generic name: amitriptyline and perphenazine [a-mee-TRIP-ti-leen-and-per-FEN-a-zeen]
Brand names: Etrafon 2-10, Etrafon 2-25, Etrafon Forte, Triavil
Dosage format: oral tablet (10 mg-2 mg; 10 mg-4 mg; mg-2 mg; 25 mg-4 mg; 50 mg-4 mg)
The class of drugs: psychotherapeutic combinations

What is Amitriptyline and perphenazine?

Amitriptyline is a tricyclic antidepressant. Perphenazine is a phenothiazine (feen-oh-THYE-a-zeen).Amitriptyline and perphenazine are combination medicines that are used for treating anxiety, depression, and anxiety.Perphenazine and amitriptyline may be used to treat conditions that are not mentioned in this guide.

Side effects of Amitriptyline and perphenazine

See a doctor immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, or tongue.If you notice any new or more severe symptoms, report them to your physician, for example, a change in your mood, behaviour, or anxieties, panic attacks, or trouble sleeping. also the feeling of being uncontrollably angry, angry, or aggressive. stressed, hyperactive (mentally as well as physically) and depressed or are contemplating suicide or taking care of yourself.Long-term use or high doses of perphenazine and amitriptyline can cause an incredibly serious disorder of movement that is not reversible. The longer you take perphenazine or amitriptyline in combination, the more likely you are to suffer from this disorder, particularly when you're a female or an older person.

Perphenazine and amitriptyline can cause severe adverse effects.Consult your physician right away in the event:

  • Uncontrolled muscle movements in your facial muscles (chewing, lip-smacking, mouth movement, frowning, blinking, or eye movements);
  • A feeling of lightheadedness that makes you feel like you've passed out;
  • Rapid, slow, or unbalanced heart rate;
  • Chest discomfort or pressure that is spreading to your shoulder or jaw;
  • Simple bleeding, unusual spots of red or purple under the skin
  • Dark blood; jaundice (yellowing of the eyes or skin);
  • A seizure (convulsions);
  • Low white blood cell count low white blood cell counts fever chills cough, mouth sores, skin ulcers, or sore throats. Cough, trouble breathing, and
  • Extreme nervous system reaction characterised by very rigid (rigid) muscles with high fever, sweating and confusion, rapid or irregular heartbeats, and fainting.

Common adverse effects of amitriptyline as well as perphenazine could be:

  • Drowsiness;
  • High blood pressure;
  • Issues with speech problems;
  • Involuntary muscle movement
  • Being agitated or unable to remain at a desk;
  • Dry mouth;
  • Headache
  • Breasts change.

This is not an exhaustive listing of all the side effects. Other side effects could occur. Consult your physician to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar/related drugs

Sertraline, Trazadone, Escitalopram, Duloxetine, Hydroxyzine, Lexapro, and Citalopram


It is not recommended to use this medication if you were recently suffering from a heart attack or were recently drinking alcohol, sedatives, tranquillizers, or any other narcotic drugs. Perphenazine and amitriptyline are not prescribed for older people suffering from dementia-related psychosis.Don't take this medication in the event that you've used an MAO inhibitor in the last 14 days, including linezolid, isocarboxazid, or methylene blue injections, phenelzine rasagiline, selegiline, or tranylcypromine.Many young people are contemplating suicide after using an antidepressant. Keep vigilant for changes regarding your mental state or the symptoms. Be sure to report any new or deteriorating symptoms to your physician.Contact your physician immediately. If you experience twitching or uncontrollable movements in your lips, eyes, face, tongue, or legs, These could be signs of potentially harmful adverse effects.

Prior to use this drug

It is not recommended to use perphenazine and amitriptyline if: suffer from an allergic reaction to amitriptyline and perphenazine;

  • You've had a heart attack
  • You have used alcohol recently or sedatives, tranquillizers, or opioid drugs.

This medication could increase the chance of death for people with dementia-related psychosis. It is not permitted for use in this manner.Do not take amitriptyline along with perphenazine if you have taken an MAO inhibitor within the past 14 days. A risky drug interaction may occur. MAO inhibitors are isocarboxazid linezolid Methylene blue injection rasagiline and phenelzine, as well as tranylcypromine and others.Discuss with your physician if you were taking any "SSRI" antidepressant in the last five weeks, including the escitalopram drug, citalopram and fluoxetine (Prozac), fluvoxamine, sertraline, paroxetine (Zoloft), trazodone, or vilazodone.

Inform your doctor if you were ever diagnosed with:

  • Glaucoma;
  • Bipolar disorder (manic depression), schizophrenia, or another mental illness
  • Epilepsy or another seizure;
  • Problems with urination;
  • Heart issues;
  • An attack on the heart and stroke;
  • A thyroid disorder
  • The liver condition
  • Breast cancer.

Young people can be prone to suicidal thoughts following the first time they take medication for depression.Your doctor should be able to check your progress regularly. Family members or other carers should be on the lookout for changes in your symptoms or mood.Antipsychotic medication taken within the last 3 months of pregnancy can result in breathing or feeding issues. It could also cause withdrawal symptoms in newborns.If you get pregnant, tell your doctor right away. You should not discontinue taking amitriptyline or perphenazine without consulting your doctor.It is not suggested breastfeeding while taking this medicine.Consult your physician about any potential risks.Avoid giving this medication to anyone who is less than 18 years of age without medical assistance.

How to take Amitriptyline and perphenazine?

Follow the directions on the prescription label and review all medication guides and instructions. Your doctor may change the dosage. Make sure you take the medication exactly as prescribed.It could take as long as 4 weeks for your symptoms to improve. Take the medication as directed Inform your physician when you notice that your symptoms aren't improving.When you are taking this medication, it is possible to require regular medical tests.If you are in need of surgery, inform the doctor ahead of time that you're taking perphenazine and amitriptyline. It is possible that you will need to discontinue using the medication for a brief period of time.Do not stop taking this medication suddenly following long-term usage, or you may experience painful withdrawal signs. Discuss with your physician how you can effectively stop taking amitriptyline or perphenazine.Keep it at room temperature, far from heat and moisture.

What happens if I miss the dose?

Do not take the medicine for as long as you are able, but do not take your missed dosage if you are nearing the time to take the next dose. Don't have two doses at one time.

What happens if I overdose?

Get medical attention immediately or contact the Poison Help Line at 1-800-222-1222. A high dose of amitriptyline or perphenazine could cause death.The signs of an overdose could include severe drowsiness, hallucinations, confusion, agitation, vomiting, sensations of heat and cold muscles, stiffness in the muscles, dilation of the pupils, or a coma.

What should be avoided?

Don't drink the alcohol. Dangerous side effects or even death could be a possibility.Perphenazine and amitriptyline can affect your reactions or thinking. Be aware when you drive or perform any activity that requires you to be aware. Be careful not to get up too fast from a lying or sitting place, or you might experience dizziness. Dizziness or drowsiness can cause falls, accidents and even severe injuries.Avoid exposure to the sun and tanning beds. Perphenazine may cause burns more quickly. Protect yourself with protective clothes and apply sunblock (SPF 30 or greater) while you're outdoors.

Interaction with other drugs

Utilising amitriptyline and/or perphenazine in conjunction with other medications that make you sleepy could make you more drowsy. Talk to your doctor prior to using an opioid drug, a sleeping pill, a muscle relaxer, or medication to treat anxiety as well as seizures.

Discuss with your doctor your other medications, including:

  • Other antidepressants or medications to treat depression, anxiety disorders, or mental illnesses;
  • Cimetidine;
  • Guanethidine;
  • The cold and allergy medicine for colds or allergies (Benadryl and others);
  • Medication for treating patients suffering from Parkinson's disease;
  • Medication to treat stomach issues, motion sickness, and IBS;
  • The use of medicine to treat symptoms of an active bladder
  • Bronchodilator asthma medicine;
  • Heart rhythm medicine;
  • Seizure medication.

This list isn't complete. Other medications can affect perphenazine and amitriptyline, which include prescription and over-the-counter medicines, vitamins, and herbal supplements. Some interactions with drugs may not be listed here. are included here.




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