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Generic Name: Alitretinoin topical [ah-lih-TREH-tin-oyn]
Classification of Drugs: Miscellaneous topical agents

What is Panretin?

The drug panretin (for your skin) is used by the adult population to manage skin lesions that are caused by AIDS-related Kaposi's sarcoma.

Panretin can also be employed for other purposes that are not covered in this medication guide.

Side effects of Panretin

See a doctor immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as hives, difficulty breathing, and swelling of your lips, face, or tongue.

Panretin could cause severe adverse effects. Consult your doctor immediately in the event that you experience:

  • Extreme burning, pain, or itchiness after using Panretin
  • Blistering, drainage, oozing,
  • Redness and swelling that are severe

Risky side effects are more likely to occur if you suffer from an autoimmune disease called T-cell lymphoma.

Common adverse effects of panretin could include:

  • The rash, itching, redness, or other skin irritations;
  • Skin peeling or flaking
  • Scabs, crusts,
  • Burn or pain in the treated skin.

This isn't a complete list of all the possible side adverse effects. Other adverse reactions could also be observed. Talk to your doctor to get medical advice regarding the consequences. It is possible to report any adverse allergic reactions or symptoms to FDA by calling 1-800-FDA-1088.


Only use according to the directions. Talk to your doctor if you are taking other medications or have any medical conditions or allergies.

Before you take this drug

Panretin is not a good choice in the event that you are allergic to alitretinoin, isotretinoin, or the ingredient tretinoin (Retin-A).

It could harm a newborn baby. Avoid using it if you are expecting. Make sure you use an effective birth control method while taking Panretin. Consult your physician if you become pregnant.Do not breastfeed.

How to take Panretin?

Follow all instructions on the label of your prescription and read the medication guide or instructions sheets. Follow the medication precisely as directed.Do not consume by mouth. The topical medication is intended for use only on the skin.

Cleanse your hands prior to and after applying this medication, except if you are treating areas of your skin on your hands.

The application of panretin usually occurs every 2 to 4 hours every day, in evenly spaced intervals. Apply only to skin lesions, and avoid healthy skin around the lesions.Let the gel dry for 3 to 5 minutes before covering the treated area with clothes. Don't cover the affected skin with the bandage unless your doctor recommends it.

Do not shower, bathe, or swim for 20 minutes prior to or for 3 hours following the application of the medication.Alitretinoin gel is flammable. Avoid using them near high temperatures or in open flames. Avoid smoking until the gel has been dried off on the skin.

It could take 14 weeks or more to see your symptoms begin to improve. Use the medication exactly as prescribed, and notify your physician if you feel your symptoms don't improve.Storage at room temperature, free of heat and moisture. Be sure to keep the medicine away from burning flames or extreme heat.

What happens If I miss a dose?

Take the medicine as fast as you are able, but avoid the missed dose if you think it is getting close to the time of the next dose. Do not take two doses at once.

What happens if I overdose?

Get medical attention immediately or contact the Poison Help line at 1-800-222-1222 in the event that anyone has accidentally swallowed the medication.

What should be avoided?

Do not get panretin in your nose, eyes, lips, mouth, rectum, the tip of your vagina, or penis. If it does happen, rinse it off with water.

Do not use insect repellents or other products that contain DEET (N,N-diethyl-m-toluamide) while using Panretin.Do not use other medicines on the areas that you treat with panretin. You can apply mineral oils to prevent drying and itching. Don't apply mineral oil more than 2 hours prior to or 2 hours following the use of this medicine.

Panretin can cause skin to burn more quickly. Avoid the sun or tanning beds. Wear protective clothing whenever you're outside.

Interaction with other drugs

Skin care products are unlikely to affect other medicines you take; however, many medications may interact. Discuss with your doctor all the medications you are currently taking, such as prescription and over-the-counter drugs, vitamins, and herbal remedies.