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Generical name: lesinurad [lee-SIN-ure-ad”
Drug class: Antihyperuricemic agents

What is Zurampic?

Zurampic assists the kidneys in removing uric acid from the body. Lesinurad is a combination of other medicines that may induce the body to make fewer uric acids.

Zurampic is used as a part of a mixture of drugs to treat the high levels of uric acid found in your blood, which is also known as hyperuricemia. Urinary acid levels that are high could cause a condition known as gout.Zurampic should be used in combination with allopurinol (Zyloprim) as well as Febuxostat (Uloric). Zurampic should not be used by itself.


It is not recommended to use Zurampic in the case of severe kidney issues or if you are on dialysis or have had an organ transplant.

Zurampic may cause kidney damage, particularly when you are taking it in conjunction with any other medications you are prescribed. Call your doctor immediately if you are urinating less frequently than normal or none at all, or if you notice swelling around your ankles or feet or a shortness of breath.

Before you take this drug

It is recommended not to take Zurampic. If you have an allergy to the chemical lesinurad, or:

  • You have a severe kidney disease.
  • You are on dialysis.
  • You have received a kidney transplant.
  • If you suffer from Lesch-Nyhan syndrome (a genetic disorder that raises the levels of uric acid in your blood), you have Lesch-Nyhan syndrome.
  • You have tumor lysis syndrome (rapid break-up of cancer cells).

To be sure Zurampic is appropriate for you, consult your physician if you suffer from:

  • Kidney disease;
  • Liver disease;
  • Heart disease heart disease
  • A stomach condition known as gastroesophageal resuscitation disease (GERD)

It is unclear if Zurampic can cause harm to a baby who is not yet born. Inform your doctor if you are expecting or planning to be pregnant.

Zurampic can make contraceptives less efficient. Consult your physician about an alternative to hormonal birth control (condom diaphragm or diaphragm that contains spermicide) to avoid pregnancy.

Other types of hormonal contraception (injection implants, injection patches for skin vaginal rings, and some intrauterine devices) aren't always sufficient to stop pregnancy while you are taking Zurampic.It isn't known if lesinurad is absorbed into breast milk or if it can harm breastfeeding babies. Consult your doctor if you are nursing a child.Zurampic is not permitted for use by anyone under 18 years of age.

How to take Zurampic?

Consume Zurampic exactly as directed by your physician. Follow the directions on the prescription label. Do not take this medication in greater or lesser quantities or for longer than the recommended time.Take all medications as directed by your physician. Review the medication guidelines or patient's instructions that come with every medication. Do not alter your dosage or your medication schedule without a physician's guidance.

Zurampic is recommended to be used together with other medications for uric acid and is not recommended to be used on its own. Lesinurad will more often trigger kidney failure if you use this medication without taking any other prescription medication.

Zurampic is best when consumed with water and food. It is best to take Zurampic at the beginning of your day along with the other medications to manage the effects of uric acid.Take at least 2 1 liters (68 grams) of fluid each day to ensure that your kidneys are functioning correctly.

Gout symptoms could become worse once you begin taking Zurampic. If you do experience a flare-up of gout, you should continue using the medication according to the directions.Consult your physician if your symptoms of gout don't improve.There may be medical tests to assess your kidney function prior to and during treatment with Zurampic.Keep at room temperature, free of heat, moisture, and light.

Details on dosage

Usual Adult Dose of Zurampic for Gout:

200 mg taken orally, once a day
Maximum dose: 200 mg per day.
Coadminister the xanthine oxidase inhibitor (e.g., allopurinol, allopurinol, or Febuxostat) when it is administered in conjunction with allopurinol daily. The total daily doses of allopurinol should not be lower than 300 mg (or less than 200 mg when crcl is less than 60 milliliters/min).
If the xanthine oxidase inhibitor is stopped, the drug must also be stopped.
This drug is not recommended to treat hyperuricemia that is not symptomatic.
Use: As an add-on treatment for hyperuricemia resulting from gout patients who have elevated serum levels of urinary acid despite treatment with an inhibitor of xanthine oxidase

Do I be concerned if I miss a dose?

Do not miss the dose if the morning has passed. Don't do Zurampic at night or later. You must wait until the next day to take the next dose. Don't take additional medicine to make up for the missed dose.

What will happen if I take excessively?

If you are experiencing medical emergencies, seek urgent medical attention, or call for assistance at the Poison Helpline at 1-800-222-1222.

What should be avoided?

Do not become dehydrated while taking this medication. Call your doctor if you are experiencing persistent diarrhea or vomiting or if you're sweating more than normal. Dehydration can lead to kidney failure.

Side effects of Zurampic

See a doctor immediately. If you are experiencing symptoms of an allergic reaction, Zurampic: hives; difficulty breathing; and swelling of your lips, face, or tongue.

See your doctor right away if you are suffering from:

  • Gout flare-up symptoms: joint stiffness, pain, swelling, redness, or pain (especially at night);
  • Kidney issues There is no or little urine, swelling of your ankles and feet, or being exhausted or lacking breath.
  • Heart issues chest pain or pressure, and pain spreading to your shoulder or jaw
  • Symptoms that a blood clot has formed: sudden numbness or weakness, issues in speech or vision, swelling, or redness on the arm or leg.

Common Zurampic adverse effects could include:

  • Irregular kidney function tests
  • Heartburn;
  • Headaches migraine
  • Flu-like symptoms.

This isn't a complete list of all the side effects. Others could happen. Contact your doctor to seek medical advice on adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Numerous drugs interact with leinurad. Some interactions may not be mentioned in this article. Inform your doctor of all your medications and any that you decide to start or stop taking, particularly:

  • Aspirin;
  • Valproic acid;
  • An antifungal or antibiotic medicine;
  • Medications for cholesterol;
  • Blood pressure or heart medication;
  • Hormonal birth control (pills, patches, implants, or certain intrauterine devices);
  • Other medications for gout

This list isn't complete, and a variety of other medications can be incompatible with lesinurad. This includes prescription and over-the-counter medications, vitamins, and herbal remedies. Provide a list of all the medicines you take to any doctor who cares for you.



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