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Generic Name: Dalfampridine [dal-FAM-pri-deen].
Name of the Brand: Ampyra.
Dosage Form: Extended-release oral tablet (10 mg).
Drug Class: Miscellaneous central nervous system agents.

What is Dalfampridine?

Dalfampridine is used to aid in improving walking for patients suffering from MS. Dalfampridine can also be used for reasons not mentioned in this medication guide.

Side effects of Dalfampridine

See a doctor immediately. If you are experiencing warning signs of an allergic response, such as symptoms of hives, difficulty breathing, and swelling of your lips, face, or tongue. Stop taking dalfampridine and contact your doctor immediately if you are experiencing seizures. Dalfampridine could cause serious adverse side effects. Contact your physician immediately. If you suffer from:

  • Burning or pain after you urinate.
  • Relapse or worsening MS symptoms.

Common adverse effects of dalfampridine could include:

  • Insufficiency, MS relapse.
  • Urination that is painful.
  • Dizziness, balance problems.
  • Numbness or tingling.
  • Sleep problems (insomnia).
  • Nausea, constipation, upset stomach.
  • Nasal congestion, sinus pain, sore throat.
  • Headache and back pain.

This is not an exhaustive list of probable side effects, and others may occur. Consult your physician to seek medical advice on the effects. You can report any symptoms to the FDA at 1-800-FDA-1088.


Dalfampridine could trigger seizures even if you've never had one before. Too much dalfampridine can increase the risk of having a seizure. Your risk may be greater if you suffer from kidney problems or are older than 50 years old. The kidney function of your patient may require testing before you begin taking dalfampridine. Stop taking dalfampridine and contact your doctor immediately if you are experiencing seizures.

Before you take this drug

It is not recommended to use this medication if you have an allergy to dalfampridine and 4-aminopyridine or if you suffer from:

  • Moderate to extreme kidney diseases.
  • If you've ever had a seizure.

Dalfampridine could trigger seizures, even if you have never experienced one before. Your risk may be increased if you suffer from kidney issues or are over 50 years old.

Inform your doctor if you have ever suffered from:

  • kidney disease.
  • If you are also taking an equivalent form of this drug purchased from an online compounding pharmacy (fampridine and 4-aminopyridine).

Senior adults could be more susceptible to the effects of this drug. It is unknown whether dalfampridine can cause harm to an unborn baby. Inform your doctor if you are expecting or planning to be pregnant. Consult your doctor for advice on whether it is safe to breastfeed while taking this medicine. Not permitted for use by anyone less than the age of 18.

How to take Dalfampridine?

Follow the instructions on the prescription label and read the medication guide or instructions sheets. Follow the medication exactly as prescribed. The use of too much dalfampridine could increase the risk of having seizures. Space your doses 12 hours apart. Don't take more than two tablets in a span of 24 hours. It is possible to take dalfampridine in combination with food or not. Take the tablet in its entirety and don't crush, chew, or tear it. Breaking the tablet can cause too much medication to be released at once, which could increase your chance of suffering a seizure. Don't use tablets that have been broken or crushed. Keep at room temperature and away from heat and moisture. Use only until the expiration date. deadline for expiration in the packaging.

Details on dosage

Usual Adult Dose for Multiple Sclerosis:

Maximum dosage: 10 mg daily orally for 12 hours
Comments: This drug can be taken in combination with food or not.
Tablets should be taken in their whole form and should not be divided or crushed. They should also not be chewed or dissolved.
Patients should not take two or more doses in the event that the dose is not taken.
Use: To enhance walking for patients of adult age with MS, as demonstrated by a rise in the speed of walking.

What happens if I miss a dose?

Do not miss the missed dose, and take your next dose at the normal time. Don't take two doses at once.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222. Overdoses can cause confusion or seizures.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on your food, drink, or activities.

Interaction with other drugs

Inform your doctor about any other medications you take, particularly:

  • Cimetidine.

This list is not comprehensive. Other medications could influence dalfampridine, such as prescription and over-the-counter medicines, vitamins, and herbal products. Some interactions with drugs are not listed here. are included here