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Generic name: pseudoephedrine [SOO-doe-ee-FED-rin]
Names of brands: Contac Cold, Nexafed, Silfedrine, Sudafed Children’s Nasal Decongestant SudoGest, Suphedrin, Drixoral Decongestant Non-drowsy
Drug class: decongestants

What is Suphedrin?

Suphedrin is a medication used to treat sinus and nasal congestion or obstruction of the tubes that draw fluid out of your ears, referred to as the eustachian tubes.

Suphedrin can also be employed for other purposes that are not covered in this guideline for medication.

Side effects Of Suphedrin

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, like hives, trouble breathing, and swelling of your lips, face, and throat, Suphedrin could have serious adverse side effects. Stop taking Suphedrin and contact your doctor immediately if you suffer from:

  • Dizziness;
  • Anxiety or
  • Sleep problems (insomnia).

The less serious side effects could be more likely, and there may be no side effects whatsoever. This is not a comprehensive list of possible side effects, and others could happen. Contact your doctor for advice regarding medical adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Follow the directions on the label as well as the packaging. Follow the instructions exactly.

Before taking this medication

It is not recommended to use Suphedrin if you are allergic to it. Avoid using Suphedrin if you've used an MAO inhibitor within the last 14 days. A risky drug interaction may occur. MAO inhibitors are isocarboxazid, linezolid, Methylene Blue injection, rasagiline, phenelzine, and tranylcypromine, among others. Consult a pharmacist or doctor to determine if this medication is suitable for you if you previously had:

  • the heart condition (also known as hypertension);
  • an overextended prostate and urinary tract problems;
  • diabetes or
  • A thyroid condition.

How to take Suphedrin?

Follow the directions on the label or as directed by your doctor. Do not give this medicine to children who are younger than four years old. Always consult a doctor prior to giving a cold or cough medicine to children. Death can occur due to the misuse of cough or cold medications in very young children.  Don't crush, chew, or break the extended-release tablet. Suck it up whole.

You might need to shake up the suspension (liquid) thoroughly prior to measuring the dosage. Dose the liquid medicine using the syringe that is used for dosing or with a measuring spoon or cup for measuring doses. If you don't have an instrument for measuring doses, request one from your pharmacist. Contact your physician if your symptoms don't improve after seven days of treatment or if you suffer from a fever. Keep at room temperature, free of heat and moisture.

What happens if I miss a dose?

Because Suphedrin is only used in times of need and not always in a schedule of doses, If you're in a routine, you should take the missed dose as quickly as you can remember. Avoid your missed dose if you are close to the time of the next dose scheduled. Don't use any extra medication to replace the missed dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

What should be avoided?

Do not take the medication when you use diuretics, caffeine pills, or any other stimulant (such as ADHD medication). Combining a stimulant with a decongestant may increase the risk of negative side effects.

Consult a physician or pharmacist before taking any other cold or cough medication. A lot of combination medications include Suphedrin or other decongestants. Combining certain medicines can result in you consuming excessive amounts of medication.

Interaction with other drugs

Other drugs can interact with Suphedrin as well, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about any other medications you take.