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Generic Name: Teriflunomide [ter-i-FLOOR-noe-mide]
Drug Class: Selective immunosuppressants

What is Aubagio?

Aubagio is a stimulant for the immune system and decreases inflammation and swelling in the nervous system.

Aubagio is utilized to treat relapsing strains of MS in adults (including those with a clinically isolated condition as well as relapsing-remitting diseases, relapsing being an active, secondary disease).Aubagio is not an effective treatment for MS.


Do not take Aubagio if you are pregnant or could be pregnant. You will need to pass a pregnancy test prior to starting this treatment. Contact your physician immediately if you become pregnant during treatment or within two years after the treatment has ended.Teriflunomide may cause serious liver issues. It is recommended not to take this medication if you suffer from severe liver disease or are using the drug leflunomide (Arava). Consult your physician if you have any previous history of liver disease.

Contact your doctor immediately if you notice symptoms of liver issues such as stomach pain, decreased appetite, dark urine, or jaundice (yellowing of the eyes or skin).

Your doctor might be required to check your liver function for up to 6 months prior to when you begin taking Aubagio, after which you will be tested every month once you start taking the medicine.Teriflunomide reduces blood cell count, which helps your body fight off infections. This could make it more difficult to fall ill when you are around people who are sick. If you take Aubagio, it is possible that you may require blood tests every six months. The blood pressure of your patients will require regular testing.If you cease using Aubagio, the drug may remain in your system for as long as two years. You might require treatment with other medicines to aid in the elimination of teriflunomide as quickly as possible. Follow your doctor's advice.

Before You Take This Drug

Aubagio is not a good choice for you. Aubagio in the event that you are allergic to teriflunomide and leflunomide or if you suffer from:

  • You have a serious liver condition. You have a severe liver disease.

  • You are also taking leflunomide (Arava).

Do not take Aubagio when there is a possibility that you might be pregnant. You must be able to pass a pregnancy test prior to beginning this treatment. Do not become pregnant until you have stopped taking the medicine and gone through a "drug elimination" procedure to rid your body of this drug. Stop Aubagio and contact your doctor immediately if you don't have a period or suspect you may have a baby.

To ensure this medication is appropriate for you, tell your physician if you have any of the following:

  • Kidney or liver disease;

  • High blood sugar levels;

  • Hypertension;

  • Skin issues when taking medicine;

  • An illness or uncontrollable infection;

  • Breathing issues;

  • Tuberculosis 

  • Nerve issues, like neuropathy.

Birth control is a method to stop pregnancy while taking medication. Once you stop taking Aubagio, use birth control until you've been tested for blood to make sure that the drug has been removed from your system.If you fall pregnant when you are taking Aubagio or within two years following the discontinuation of the medication, your name might be included on the pregnancy registry. This is done to monitor the results of the pregnancy and assess the effects of teriflunomide on the infant.

If you're male, use effective birth control to stop pregnancy in the event that your partner becomes pregnant. Once your treatment has ended and you are no longer using birth control, continue to use it until you've received drugs to assist the body in eliminating teriflunomide.It is recommended not to breastfeed when using this medication.

How To Take Aubagio?

Before starting treatments with Aubagio, your physician might run tests to be sure you aren't suffering from tuberculosis or any other infection.

Follow the instructions on your prescription label and review all medication guides and instruction sheets. The doctor might alter your dosage. Make sure you take the medicine exactly as prescribed.You can take Aubagio in combination with food or not.

Your blood pressure should be regularly monitored.

Teriflunomide could lower blood cell counts. Your blood must be checked frequently. The treatment you receive could be delayed, depending on the results.

When you have stopped taking Aubagio, you may have to take other medications to help the body eliminate teriflunomide rapidly. If you don't undergo the process of eliminating this drug, teriflunomide can remain within your body for as long as two years. Follow the instructions of your physician.You should also complete this drug elimination procedure if you intend to get pregnant after stopping the medication.Keep at room temperature, away from heat and moisture.

Details On Dosage

Usual Adult Dose for Multiple Sclerosis:

7, 14, or 7 mg taken orally every day

Treatment of patients suffering from relapsing forms of MS

What Happens If I Overdose?

Do not take the medicine for as long as you are able, but avoid your missed dose if you are nearing the time to take the next dose. Don't take two doses at a time.

What Happens If I Overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What Should be Avoided?

Avoid being around those who are suffering from colds, flu, or any other infectious illnesses. Get your doctor's attention immediately when you begin to show symptoms of an infection.Do not get a "live" vaccine while using Aubagio or for at least six months after stopping taking it. The vaccine might not function at all during this period, and it may not completely safeguard you against disease. Measles is a live virus that includes rubella, mumps (MMR), and rotavirus. yellow fever, typhoid varicella (chickenpox), zoster (shingles), and the nasal influenza (influenza) vaccine.

Side Effects Of Aubagio

See a doctor immediately when you notice symptoms that you are experiencing an allergic reaction due to the Aubagio (hives and breathing difficulties or swelling in your throat or face) or a severe reaction to your skin (fever or burning eyes, sore throat or skin pain, an ailment that is purple or red that blisters and peels).Stop using this medicine immediately and consult your physician immediately if you are suffering from:

  • Tingling or numbness in your feet or hands that is different from MS symptoms;

  • Difficulty breathing, a more severe or new cough, or no fever;

  • Indications of infection: chills, fever, body discomfort, nausea, vomiting, and feeling tired;

  • Liver issues, liver problems, upper stomach discomfort, a loss of appetite, bloody urine and jaundice (yellowing of the eyes or skin).

Common Aubagio side effects include:

  • Headache;

  • Nausea, diarrhea;

  • Hair loss 

  • Unusual liver function tests.

This is not a comprehensive list of possible side effects, and others could happen. Consult your physician for advice regarding medical effects.

If you have any concerns, report the allergic reactions or symptoms to FDA by dialing 1-800-FDA-1088.

Interaction With Other Drugs

It is sometimes not recommended to take certain medications simultaneously. Certain medications can alter the blood levels and the other medications you are taking, which could create side effects or render the medication less effective.Your doctor may have to alter the dosage of other medicines you use on a regular basis.

A variety of drugs may react with teriflunomide. This includes over-the-counter and prescription medications, vitamins, and herbal products. The interactions of all drugs are mentioned here. Inform your doctor of all the medicines you are currently taking and any other medications you are about to start or stop taking.




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