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Zofran ODT

Generic name: Ondansetron (oral) [on-DAN-se-tron]
Drug class: 5HT3 receptor antagonists

There is no Zofran ODT brand name. The Zofran ODT brand name has been removed within the U.S. by thein the event that generic variants of this product are cleared by FDA, There may be generic alternatives available.

What is Zofran ODT?

Zofran odtblocks block the actions of the body's chemicals that trigger vomiting.Zofran ODT helps stop vomiting and nausea that could result from surgical procedures, cancer chemotherapy, or radiation therapy.Zofran ODT can be used for reasons not covered in this guideline.

Zofran ODT side effects

Take immediate medical care. If you are experiencing symptoms that are warning signs of an allergic reaction, such as itching and hives, fever,face, chills, difficulty breathing, or swelling of your lips, face and throat,

Zofran ODT may cause serious side effects. Contact your doctor immediately in the event that you experience:

  • Extreme constipation, or stomach pain, or constipation that is severe;
  • Headache that causes chest pain, extreme dizziness, fainting, rapid, or pounding heartbeats;
  • Rapid heartbeats or fast beats;
  • Jaundice (yellowing of the eyes or skin);
  • Blurred vision or temporary vision loss (lasting between a few minutes and more than a few hours);
  • Serotonin levels are high within the body: anxiety, hallucinations, fever, fast heart rate, excessively active reflexes, nausea, diarrhea, inability to control, and fainting.

Common adverse consequences of Zofran ODT can include:

  • Constipation or diarrhea;
  • Headache;
  • Drowsiness;
  • Fatigued feeling.

It's not a comprehensive listing of all negative consequences. There are other possibilities for this to happen. Talk to your doctor about medical-related adverse reactions. It is possible to report any adverse reaction to FDA by calling 1-800-FDA-1088.

Similar or related drugs

Hydroxyzine, ondansetron, Lorazepam, meclizine, dexamethasone, Benadryl, and Zofran


You shouldn't take Zofran ODT when you are taking Apomorphine (Apokyn).

Before you take this drug

It is not recommended to apply Zofran ODT if:

  • If you're also using the drug apomorphine (Apokyn), also known as
  • You are allergic to Zofran ODT or similar medicines (dolasetron, granisetron, or palonosetron).

To ensure that Zofran ODT is appropriate for you, ask your doctor if you suffer from:

  • Liver disease;
  • An electrolyte imbalance (such as low concentrations of magnesium or potassium within your blood);
  • Constipation and heart problems slow heartbeats, congestive heart failure;
  • A family or personal background of the syndrome of long QT
  • An obstruction inside your stomach (the stomach or the intestines).

Zofran ODT is not believed to harm the unborn baby. Consult your physician if you are expecting.It's not clear if ondansetron is absorbed into breast milk or whether it can harm the nursing infant. Consult your physician if you are breastfeeding.

Zofran ODT is not a product that is approved to be used by anyone less than 4 years of age.Zofran tablets that disintegrate organically might contain phenylalanine. Inform your doctor that you have the condition known as phenylketonuria (PKU).

How to take Zofran ODT?

Follow the directions on the prescription label. Don't use Zofran ODT in smaller or greater quantities or for a longer time than the recommended time.Zofran ODT is a medicine that can be consumed without or with food.

The initial dose of ondansetron is usually administered prior to the beginning of your chemotherapy, surgery, or radiation therapy. Follow the dosing guidelines of your physician with care.Use your Zofran ODT regular tablet with a glass of water.To take the oral tablets that disintegrate (Zofran ODT):

  • Place the tablet in its blister package until you are ready to take it. Unlock the box and peel off the foil. Don't push a tablet into the foil, as you could cause damage to the tablet.
  • Dry hands are the best way to remove the tablet from its packaging and put it in your mouth.
  • Do not take the tablet in its entirety. It will dissolve into your mouth with no chewing.
  • Drink several times until the tablet disintegrates.

To use Zofran ODT-soluble film (strip) (Zuplenz):

  • Place your strip inside the pouch made of foil until you're ready to apply the medication.
  • With clean hands, take the strip from your hands and put it on your tongue. It will begin to break down in a matter of minutes.
  • Don't swallow the entire strip. It will dissolve into your mouth with no chewing..
  • Drink several times until the strip has disintegrated. If you want, take a drink to assist in swallowing the strip that has disintegrated.
  • Cleanse your hands after you have used Zuplenz.

Measure the amount of liquid medicine using the syringe for dosing, a measuring spoon, or a medicine cup. If you don't have an instrument for measuring doses, you can ask your pharmacist for one.

Be sure to keep the temperature at room temperature. Far from moisture, heat and the light. Place the liquid medicine upright.

What happens if I miss a dose?

You should take the missed dose as quickly as you can remember. Avoid your missed dose if it's close to the time of the next dose. Do not take any additional medicine to make up for the missed dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222.

Overdose symptoms can include sudden vision loss and severe constipation. It can also cause you to feel lightheaded or faint.

Avoid this

Zofran ODT could affect your reactions or thinking. Be aware when driving or doing any activity that requires your attention. Aware.

Interaction with other drugs

Zofran ODT could cause severe heart conditions, particularly in the event that you are taking certain medications simultaneously, such as antidepressants, antibiotics, heart rhythm medicines, and antipsychotic drugs, as well as medications to treat malaria, cancer, HIV, or AIDS. Inform your doctor about the medicines you take and the ones you begin or stop using in the course of treatment for this drug.

Zofran ODT when you are taking other medications can result in excessive levels of serotonin accumulating within your body, which is known as "serotonin syndrome," which could be fatal. Inform your doctor that you also take:

  • Medications used to manage depressive symptoms;
  • Medication to treat a psychiatric disorder
  • A prescription for a narcotic (opioid) drug;
  • Medicine to reduce nausea or vomiting.

This isn't a complete list, and other drugs may interfere with Zofran ODT. This includes prescription as well as over-the-counter medications, vitamins, and herbal remedies. Make an inventory of all your medications and give it to any doctor who cares for you.



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