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Generic Name: Belinostat [be-LIN-oh-stat]

Drug class: Histone deacetylase inhibitors

What is Beleodaq?

Beleodaq is a treatment for cancer that blocks the spread and growth of cancer cells within the body. Beleodaq injections are utilized in the treatment of cancer of the peripheral lymphoma following other treatments for cancer that failed or ended up failing. Beleodaq has been approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical trials, non-small cell lung tumors have responded to this medication. But it hasn't been demonstrated that belinostat could help improve symptoms or extend the duration of survival.


Beleodaq can affect the immune system. It can cause infections more frequently and even deadly or life-threatening diseases. Call your doctor when you experience an illness that causes chills, fever, coughing, or flu-like symptoms, or if you notice unusual bleeding or bruises.

Belinostat can harm your unborn baby. It is best not to get pregnant while taking Beleodaq. Inform your doctor immediately if you fall pregnant while taking this medicine.

Beforeyou take this drug

To ensure that Beleodaq is suitable for you, inform your physician if you've ever experienced:

  • An infection.
  • Intense chemotherapy or high doses.
  • kidney disease or liver failure.
  • If you're sick and suffering from vomiting or diarrhea.

Belinostat could harm an unborn child when the father or mother uses this medication.

  • If you're pregnant, do not use Beleodaq. You might need to undergo an unconfirmed pregnancy test prior to taking this medication. Utilize effective birth control methods to stop pregnancy while taking this medicine and for a minimum of 6 months following your last dose.
  • If you're male, use effective birth control when your partner can get pregnant. Use birth control for a minimum of three months following your last dose.
  • Contact your physician immediately when you notice a pregnancy in the presence of either the mother or the father taking Beleodaq.

Avoid breastfeeding while taking this medicine and for at least 2 weeks following the last dose.

How to take Beleodaq?

Beleodaq injections are delivered as an injection into the vein. Your healthcare provider will offer the injection.

The medication must be administered slowly, and the infusion may last for at least 30 minutes before it is completed. Beleodaq is administered in a 21-day cycle of treatment. It is possible that you will need to take the medication only for the first five days of every cycle. Your physician will decide the duration of treatment with this medicine. It is possible to receive medication to help prevent nausea or vomiting and diarrhea if you are taking Beleodaq. Belinostat impacts the immune system. You could contract infections more frequently, even deadly or life-threatening infections. The blood of your patient will be checked weekly during every treatment cycle. The treatment for cancer may be delayed depending on the results.

Details on dosage

Usual Adult Dose for Lymphoma:

1,000 mg/m2 IV for 30 minutes every day between days 1 and 5 of the 21-day period
The duration of the treatment The cycle is repeated every 21 days until the disease progresses or the toxicity is unacceptable.
Comments: Dose reduction, discontinuation, or even interruption of therapy might be required to control adverse reactions.
Relapsed or refractory T-cell lymphoma of the peripheral blood

What happens if I miss a dose?

Consult your physician for the appropriate treatment. If you do not make the appointment for the Beleodaq injection,

What happens if I overdose?

Because the medicine is prescribed by a medical expert in a medical environment, the risk of overdose is less likely to occur.

What should be avoided?

Beware of those with illnesses or who suffer from infections. Contact your doctor right away when you begin to show symptoms of an infection. Avoid activities that increase the chances of sustaining injuries or bleeding. Take extra care to avoid bleeding when shaving or brushing your teeth.

Side effects of Beleodaq

Take immediate medical attention if you show symptoms that you are experiencing an allergic reaction due to the Beleodaq, such as itching, breathing problems, and swelling of your lips, tongue, throat, or face.

Contact your doctor immediately. If you suffer from:

  • Severe ongoing nausea, vomiting, or diarrhea.
  • A fever, chills, muscle discomfort, and flu-like symptoms.
  • Cough that is mucus-filled chest pain, rapid heartbeats, rapid breathing, or shortness of breath.
  • Simple bleeding, unusual bruising, or the appearance of red or purple spots beneath your skin.
  • Burning or pain during urination.
  • Confusion, severe drowsiness, feeling very ill.
  • Liver issues: nausea and abdominal discomfort (upper right side) fatigue, itching, and dark urine; stools that are clay-colored; jaundice (yellowing of the eyes or skin).
  • Red blood cell count is low (anemia): pale skin, unusual fatigue sensation of lightheadedness or shortness of breath, cold feet and hands.
  • Indications of the breakdown of tumor cells: weakening, fatigue, muscle cramps, nausea, vomiting, diarrhea, rapid as well as low heart rates, as well as tingling on your feet, hands, and around the mouth.

Common Beleodaq adverse reactions could include:

  • Nausea, vomiting, diarrhea.
  • Anemia.
  • Fever.
  • Tiredness.

This is not a comprehensive list of all the possible side effects. Others could happen. Contact your doctor for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Other medications can interact with belinostat. This includes medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about all the medicines you are currently taking and any medication you begin or stop taking.